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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdkl5
cyclin dependent kinase like 5
MGI:1278336
23 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdkl5tm1.1Cogr/Cdkl5+
Tg(Emx1-cre)#Ito/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J 		normal behavior/neurological phenotype J:209635
limb grasping J:209635
Cdkl5tm1.1Cogr/Y
Tg(dlx5a-cre)1Mekk/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1 		normal behavior/neurological phenotype J:209635
Cdkl5tm1.1Cogr/?
Tg(dlx5a-cre)1Mekk/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1 		normal behavior/neurological phenotype J:209635
decreased locomotor activity J:209635
Cdkl5tm1.1Cogr/Y
Tg(Emx1-cre)#Ito/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J 		normal behavior/neurological phenotype J:209635
limb grasping J:209635
Cdkl5tm1.1Joez/Y
B6.129(FVB)-Cdkl5tm1.1Joez 		abnormal nervous system electrophysiology J:193172
abnormal nest building behavior J:193172
decreased anxiety-related response J:193172
hyperactivity J:193172
impaired contextual conditioning behavior J:193172
impaired coordination J:193172
impaired cued conditioning behavior J:193172
limb grasping J:193172
normal nervous system phenotype J:193172
social withdrawal J:193172
normal taste/olfaction phenotype J:193172
Cdkl5tm1.2Cogr/Cdkl5+
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J 		abnormal visual evoked potential J:209635
decreased locomotor activity J:209635
limb grasping J:209635
Cdkl5tm1.2Cogr/Y
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J 		abnormal seizure response to inducing agent J:209635
abnormal visual evoked potential J:209635
decreased locomotor activity J:209635
limb grasping J:209635
seizures J:209635
Cdkl5tm1.2Cogr/Cdkl5+
Tg(Thy1-YFP)#Jrs/0
involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA 		abnormal dendrite morphology J:209635
thin cerebral cortex J:209635
Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J 		abnormal seizure response to inducing agent J:209635
abnormal visual evoked potential J:209635
decreased locomotor activity J:209635
limb grasping J:209635
seizures J:209635
Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr
Tg(Thy1-YFP)#Jrs/0
involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA 		abnormal dendrite morphology J:209635
abnormal hippocampus layer morphology J:209635
thin cerebral cortex J:209635
thin hippocampus molecular cell layer J:209635
thin hippocampus stratum oriens J:209635
Cdkl5tm1.2Cogr/Y
Tg(Thy1-YFP)#Jrs/0
involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA 		abnormal dendrite morphology J:209635
abnormal hippocampus layer morphology J:209635
thin cerebral cortex J:209635
thin hippocampus molecular cell layer J:209635
thin hippocampus stratum oriens J:209635
Cdkl5tm1.3Cogr/?
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J 		abnormal behavior J:209635
Cdkl5tm1dIcs/Y
C57BL/6N-Cdkl5tm1dIcs/Ics 		decreased respiratory quotient J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory