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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ppt1
palmitoyl-protein thioesterase 1
MGI:1298204
50 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ppt1tm1.1Dprc/Ppt1tm1.1Dprc
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 		abnormal microglial cell activation J:213552
abnormal motor coordination/balance J:213552
astrocytosis J:213552
decreased exploration in new environment J:213552
impaired coordination J:213552
increased body weight J:213552
lipofuscinosis J:213552
Ppt1tm1Aj/Ppt1tm1Aj
involves: 129S4/SvJae * C57BL/6 		abnormal brain morphology J:95522
abnormal cerebral cortex morphology J:95522
abnormal hippocampus morphology J:95522
abnormal kidney morphology J:95522
abnormal liver morphology J:95522
abnormal podocyte morphology J:95522
abnormal retina neuronal layer morphology J:95522
abnormal spleen morphology J:95522
blindness J:95522
brain atrophy J:95522
brain inflammation J:95522
decreased brain weight J:95522
hindlimb paralysis J:95522
limb grasping J:95522
loss of cortex neurons J:95522
loss of GABAergic neurons J:95522
myoclonus J:95522
neurodegeneration J:95522
premature death J:95522
seizures J:95522
Ppt1tm1Hof/Ppt1tm1Hof
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6 		abnormal brain morphology J:177265
abnormal cytokine level J:177265
abnormal visual cortex morphology J:177265
astrocytosis J:177265
brain atrophy J:177265
brain inflammation J:177265
decreased brain weight J:177265
hippocampal neuron degeneration J:177265
neurodegeneration J:177265
premature death J:177265
thin cerebral cortex J:177265
Ppt1tm1Hof/Ppt1tm1Hof
involves: 129S6/SvEvTac * C57BL/6J 		abnormal aggression-related behavior J:72931
abnormal brain morphology J:72931
abnormal gait J:72931
abnormal retina cone bipolar cell morphology J:280337
abnormal retina rod bipolar cell morphology J:280337
astrocytosis J:280337
decreased brain size J:72931
decreased grooming behavior J:72931
decreased retina cone cell number J:280337
decreased retina photoreceptor cell number J:280337
decreased total retina thickness J:280337
hindlimb paralysis J:72931
hippocampal neuron degeneration J:72931
jerky movement J:72931
microgliosis J:280337
myoclonus J:72931
neurodegeneration J:72931
premature death J:72931
Purkinje cell degeneration J:72931
retina deposits J:280337
retina ganglion cell degeneration J:280337
retina gliosis J:280337
retina photoreceptor degeneration J:280337
thick neurocranium J:72931
thin retina inner nuclear layer J:280337
thin retina outer nuclear layer J:280337
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory