Slc7a5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc7a5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
MGI:1298205

31 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc7a5^em1(IMPC)H/Slc7a5⁺ C57BL/6NTac-Slc7a5^em1(IMPC)H/H	increased basophil cell number	J:211773
	increased circulating potassium level	J:211773
	increased mean corpuscular volume	J:211773
Slc7a5^em1(IMPC)H/Slc7a5^em1(IMPC)H C57BL/6NTac-Slc7a5^em1(IMPC)H/H	preweaning lethality, complete penetrance	J:211773
Slc7a5^tm1.1Daca/Slc7a5^tm1.1Daca Tg(Ckmm-cre)5Khn/? involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal amino acid level	J:213820
	increased gonadal fat pad weight	J:213820
	insulin resistance	J:213820
Slc7a5^tm1.1Daca/Slc7a5^tm1.1Daca Tg(Tek-cre)12Flv/0 B6J.Cg-Slc7a5^tm1.1Daca Tg(Tek-cre)12Flv	abnormal amino acid level	J:238065
	abnormal amino acid metabolism	J:238065
	abnormal behavior	J:238065
	abnormal CNS synaptic transmission	J:238065
	abnormal gait	J:238065
	abnormal inhibitory synapse morphology	J:238065
	abnormal miniature excitatory postsynaptic currents	J:238065
	abnormal social investigation	J:238065
	abnormal symmetric synapse morphology	J:238065
	abnormal synaptic bouton morphology	J:238065
	abnormal synaptic vesicle number	J:238065
	abnormal translation	J:238065
	decreased locomotor activity	J:238065
	decreased miniature inhibitory postsynaptic current frequency	J:238065
	decreased vertical activity	J:238065
	excessive vocalization	J:238065
	impaired coordination	J:238065
	increased phenylalanine level	J:238065
	increased serine level	J:238065
	kyphosis	J:238065
	limb grasping	J:238065
	motor developmental delay	J:238065
	normal nervous system phenotype	J:238065
	short stride length	J:238065
Slc7a5^tm1.2Daca/Slc7a5^tm1.2Daca involves: 129P2/OlaHsd * C57BL/6	embryonic lethality, complete penetrance	J:213820
Slc7a5^tm1Lex/Slc7a5^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:171883

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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