Hcn4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hcn4
hyperpolarization-activated, cyclic nucleotide-gated K+ 4
MGI:1298209

15 phenotypes from 8 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hcn4^{tm1(cre/ERT2)Anlu}/Hcn4⁺ Not Specified	normal cardiovascular system phenotype	J:139266
Hcn4^{tm1(cre/ERT2)Anlu}/Hcn4⁺ Not Specified	no abnormal phenotype detected	J:139266
Hcn4^tm1.1Ggc/Hcn4^tm1.1Ggc A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S/SvEv C57BL/6 * FVB/N	abnormal impulse conducting system conduction	J:168248
	abnormal sinoatrial node conduction	J:168248
	atrioventricular block	J:168248
	decreased heart rate	J:168248
	premature death	J:168248
	prolonged PQ interval	J:168248
Hcn4^tm1.1Jsr/Hcn4^tm1.1Jsr involves: 129/Sv * C57BL/6	abnormal heart rate	J:86988
Hcn4^tm1.1Jsr/Hcn4^tm1.1Jsr involves: 129/Sv * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:86988
Hcn4^tm1Jsr/Hcn4^{tm1(cre/ERT2)Anlu} involves: 129S1/Sv * 129X1/SvJ	abnormal impulse conducting system conduction	J:139266
	decreased heart rate	J:139266
	sinoatrial block	J:139266
Hcn4^tm1Jsr/Hcn4^tm1Jsr Myl2^tm1(cre)Krc/Myl2⁺ involves: 129	embryonic lethality during organogenesis, complete penetrance	J:86988
Hcn4^tm1Nnka/Hcn4⁺ involves: C57BL/6NCrlj * CBA/JNCrlj	abnormal nervous system electrophysiology	J:207953
	abnormal olfactory bulb glomerular layer morphology	J:207953
	small olfactory bulb	J:207953
Hcn4^tm1Sev/? Not Specified	no abnormal phenotype detected	J:156167
Hcn4^{tm2.1(cre/ERT2)Sev}/Hcn4^{tm2.1(cre/ERT2)Sev} involves: Black Swiss * C57BL/6J	embryonic lethality, complete penetrance	J:101977
Hcn4^tm3Sev/Hcn4^tm3Sev involves: Black Swiss * C57BL/6J	embryonic lethality, complete penetrance	J:101977

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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