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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hcn4
hyperpolarization-activated, cyclic nucleotide-gated K+ 4
MGI:1298209
10 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Hcn4tm1(cre/ERT2)Anlu/Hcn4+
involves: 129S/SvEv
abnormal sinoatrial node morphology J:186021
atrioventricular block J:186021
cardiac fibrosis J:186021
decreased heart rate J:186021
increased heart rate variability J:186021
irregular heartbeat J:186021
premature death J:186021
prolonged PR interval J:186021
Hcn4tm1Rsei/Hcn4+
B6.Cg-Hcn4tm1Rsei
decreased heart rate J:131820
Hcn4tm1Rsei/Hcn4tm1Rsei
B6.Cg-Hcn4tm1Rsei
decreased cardiac muscle contractility J:131820
decreased heart rate J:131820
embryonic lethality during organogenesis, complete penetrance J:131820

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory