Hcn2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hcn2
hyperpolarization-activated, cyclic nucleotide-gated K+ 2
MGI:1298210

41 phenotypes from 11 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hcn2^ap/Hcn2⁺ DW/Pas-Hcn2^ap	abnormal spike wave discharge	J:146530
	absence seizures	J:146530
	increased susceptibility to pharmacologically induced seizures	J:146530
Hcn2^ap/Hcn2^ap DW/Pas-Hcn2^ap	abnormal emotion/affect behavior	J:146530
	abnormal gait	J:146530
	abnormal locomotor coordination	J:146530
	abnormal posture	J:146530
	abnormal spike wave discharge	J:146530
	absence seizures	J:146530
	ataxia	J:146530
	decreased body length	J:146530
	decreased body weight	J:146530
	decreased locomotor activity	J:146530
	impaired balance	J:146530
	impaired swimming	J:146530
	increased stereotypic behavior	J:146530
	premature death	J:146530
	tonic-clonic seizures	J:146530
	tremors	J:146530
Hcn2^ap/Hcn2^ap involves: C57BL/6J * DW/Pas	abnormal depression-related behavior	J:173355
	decreased body size	J:173355
	decreased food intake	J:173355
	decreased locomotor activity	J:173355
	impaired coordination	J:173355
	impaired swimming	J:173355
	infertility	J:173355
	premature death	J:173355
Hcn2^m1Btlr/Hcn2^m1Btlr C57BL/6J-Hcn2^m1Btlr	ataxia	J:255187
	decreased body weight	J:255187
	decreased CD8-positive, alpha-beta T cell number	J:255187
	increased CD4-positive, alpha-beta T cell number	J:255187
Hcn2^m2Btlr/Hcn2^m2Btlr C57BL/6J-Hcn2^m2Btlr	decreased body weight	J:267669
	impaired balance	J:267669
	impaired coordination	J:267669
Hcn2^m3Btlr/Hcn2^m3Btlr C57BL/6J-Hcn2^m3Btlr	decreased body weight	J:272834
Hcn2^m4Btlr/Hcn2^m4Btlr C57BL/6J-Hcn2^m4Btlr	decreased body weight	J:274859
Hcn2^tm1.1Lex/Hcn2^tm1.1Lex Scn10a^tm2(cre)Jwo/Scn10a⁺ involves: 129 * C57BL/6	abnormal nociception after inflammation	J:176663
	abnormal touch/ nociception	J:176663
	increased chemical nociceptive threshold	J:176663
	increased thermal nociceptive threshold	J:176663
Hcn2^tm1.2Lex/Hcn2^tm1.2Lex involves: BALB/cJ * C57BL/6	abnormal action potential	J:176663
	abnormal neuron physiology	J:176663
	ataxia	J:176663
	premature death	J:176663
Hcn2^tm1Ldw/Hcn2^tm1Ldw involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal afterhyperpolarization	J:81398
	abnormal nervous system electrophysiology	J:81398
	abnormal sinoatrial node conduction	J:81398
	abnormal summary potential	J:81398
	absence seizures	J:81398
	decreased body weight	J:81398
	decreased channel response intensity	J:81398
	decreased locomotor activity	J:81398
	irregular heartbeat	J:81398
	tremors	J:81398
Hcn2^tm1Ldw/Hcn2^tm2Ldw Myl7^tm1(cre)Krc/Myl7⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal sinoatrial node conduction	J:81398
	irregular heartbeat	J:81398
Hcn2^trls-2J/Hcn2^trls-2J B6.WB-Hcn2^trls-2J/J	decreased body size	J:140623
	postnatal lethality, incomplete penetrance	J:140623
	tremors	J:140623
Hcn2^trls/Hcn2^trls Not Specified	azoospermia	J:103185
	decreased body size	J:103185
	increased or absent threshold for auditory brainstem response	J:103185
	lethality at weaning, incomplete penetrance	J:103185
	normal nervous system phenotype	J:103185
	tremors	J:103185

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