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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp6
low density lipoprotein receptor-related protein 6
MGI:1298218
125 phenotypes from 11 alleles in 22 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lrp6Cd/Lrp6+
A-Lrp6Cd 		abnormal caudal vertebrae morphology J:13045
abnormal lumbar vertebrae morphology J:13045
abnormal sacral vertebrae morphology J:13045
abnormal vertebrae morphology J:13045
kinked tail J:13045, J:58433
small caudal vertebrae J:13045
vertebral fusion J:13045
Lrp6Cd/Lrp6+
involves: A * 129/Sv 		kinked tail J:58433
Lrp6Cd/Lrp6+
involves: A * C57BL/6 		kinked tail J:58433
Lrp6Cd/Lrp6+
involves: A * DBA 		kinked tail J:58433
Lrp6Cd/Lrp6Cd
A-Lrp6Cd 		abnormal caudal vertebrae morphology J:13045, J:101423
abnormal coat appearance J:13045
abnormal cranium morphology J:13045
abnormal frontal bone morphology J:13045
abnormal head movements J:13045
abnormal head shape J:13045
abnormal lumbar vertebrae morphology J:13045, J:101423
abnormal molar cusp morphology J:12999
abnormal nose morphology J:13045
abnormal outer ear morphology J:13045
abnormal sacral vertebrae morphology J:13045
abnormal somite development J:101423
abnormal tail ring morphology J:12999, J:13045
abnormal tooth development J:12998
abnormal tooth eruption J:12999, J:13045
abnormal vertebrae morphology J:13045
anophthalmia J:13045
caudal vertebral fusion J:13045, J:101423
decreased birth body size J:12998
decreased body size J:13045, J:58433
decreased molar number J:12998, J:12999
decreased somite size J:101423
delayed bone ossification J:13045
delayed cranial suture closure J:13045
embryonic lethality before implantation, incomplete penetrance J:13045, J:58433
exencephaly J:13045, J:58433, J:101423
growth retardation of molars J:12998
hemivertebra J:101423
kinked tail J:13045
long upper incisors J:13045
microphthalmia J:12999, J:13045
neonatal lethality, incomplete penetrance J:13045, J:58433
postnatal growth retardation J:13045
prenatal lethality, incomplete penetrance J:13045
short incisors J:12998
small caudal vertebrae J:13045
small cranium J:13045
small lower incisors J:12999
small molars J:12998, J:12999
sparse hair J:12999, J:13045
thin neurocranium J:13045
Lrp6Cd/Lrp6Gt(Ex187)Byg
involves: 129P2/OlaHsd * A 		abnormal vertebrae development J:101423
exencephaly J:101423
kinked tail J:101423
prenatal lethality J:101423
vertebral fusion J:101423
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N 		decreased bone mineral density J:111359
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
involves: 129P2/OlaHsd 		abnormal external female genitalia morphology J:155250
abnormal external male genitalia morphology J:155250
incomplete somite formation J:93008
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal cerebellum morphology J:64989
abnormal digit morphology J:64989
abnormal midbrain morphology J:64989
abnormal midbrain-hindbrain boundary morphology J:64989
abnormal tail bud morphology J:64989
absent apical ectodermal ridge J:64989
absent inferior colliculus J:64989
absent paraxial mesoderm J:64989
absent vertebrae J:64989
exencephaly J:64989
forelimb oligodactyly J:64989
incomplete somite formation J:64989
perinatal lethality, complete penetrance J:64989
sirenomelia J:64989
small tail bud J:64989
spina bifida J:64989
Lrp6Gt(LST067)Byg/Lrp6+
B6.Cg-Lrp6Gt(LST067)Byg 		abnormal brown adipose tissue morphology J:182772
abnormal liver morphology J:182772
abnormal liver physiology J:182772
decreased body weight J:182772
decreased circulating glucose level J:182772
decreased liver triglyceride level J:182772
decreased susceptibility to diet-induced obesity J:182772
decreased susceptibility to induced hypothermia J:182772
improved glucose tolerance J:182772
increased brown fat cell number J:182772
increased circulating adiponectin level J:182772
increased insulin sensitivity J:182772
Lrp6Gt(LST067)Byg/Lrp6+
involves: 129P2/OlaHsd 		abnormal lipid homeostasis J:155275
Lrp6Gw/Lrp6+
involves: 101/H * BALB/c * C3H/HeH 		abnormal forebrain morphology J:170646
abnormal head morphology J:170646
kinked tail J:170646
Lrp6Gw/Lrp6+
involves: 101/H * BALB/cOlaHsd * C3H/HeH 		kinked tail J:93195
Lrp6Gw/Lrp6Gw
involves: 101/H * BALB/c * C3H/HeH 		abnormal head morphology J:170646
abnormal telencephalon morphology J:170646
forebrain hypoplasia J:170646
kinked tail J:170646
Lrp6Gw/Lrp6Gw
involves: 101/H * BALB/cOlaHsd * C3H/HeH 		abnormal forebrain development J:93195
decreased embryo size J:93195
exencephaly J:93195
Lrp6m10Bei/Lrp6m10Bei
involves: A/J * C57BL/6 		abnormal neural tube closure J:199782
craniorachischisis J:199782
exencephaly J:199782
spina bifida J:199782
Lrp6rs/Lrp6Gt(Ex187)Byg
involves: 129P2/OlaHsd * BALB/c 		incomplete somite formation J:93008
Lrp6rs/Lrp6rs
involves: BALB/c 		abnormal dorsal-ventral polarity of the somites J:93008
abnormal paraxial mesoderm morphology J:93008
abnormal vertebrae morphology J:93008
abnormal vertebral arch morphology J:93008
curly tail J:93008
delayed bone ossification J:93008
fused dorsal root ganglion J:93008
incomplete somite formation J:93008
oligodactyly J:93008
osteoporosis J:93008
postnatal lethality, incomplete penetrance J:93008
rib fusion J:93008
short tail J:93008
spina bifida cystica J:93008
spina bifida occulta J:93008
Lrp6rs/Lrp6rs
involves: BALB/c * C57BL/6 		curly tail J:93008
short tail J:93008
Lrp6skax26/Lrp6+
involves: 129S6/SvEvTac * C57BL/6J 		curly tail J:206979
kinked tail J:206979
Lrp6skax26/Lrp6skax26
involves: 129S6/SvEvTac * C57BL/6J 		abnormal orientation of outer hair cell stereociliary bundles J:206979
curly tail J:206979
kinked tail J:206979
Lrp6skax26/Lrp6skax26
involves: C57BL/6J 		curly tail J:89098
kinked tail J:89098
Lrp6tm1.1Vari/Lrp6tm1.1Vari
involves: 129S1/Sv 		no abnormal phenotype detected J:178499
Lrp6tm1.1Vari/Lrp6tm1.1Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ 		delayed bone ossification J:178499
normal skeleton phenotype J:178499
Lrp6tm1.1Vari/Lrp6tm1.2Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ 		delayed bone ossification J:178499
normal skeleton phenotype J:178499
Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg
involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL 		abnormal external female genitalia morphology J:155250
abnormal external male genitalia morphology J:155250
abnormal eye development J:155250
abnormal limb morphology J:155250
exencephaly J:155250
failure of eyelid fusion J:155250
microphthalmia J:155250
retina coloboma J:155250
short tail J:155250
spina bifida J:155250
Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
involves: C57BL/6J * CD-1 * SJL 		abnormal digit morphology J:155250
abnormal external female genitalia morphology J:155250
abnormal external male genitalia morphology J:155250
abnormal eye development J:155250
abnormal forelimb morphology J:155250
abnormal hindlimb morphology J:155250
abnormal limb morphology J:155250
cleft palate J:155250
cleft upper lip J:155250
exencephaly J:155250
failure of eyelid fusion J:155250
forelimb oligodactyly J:155250
microphthalmia J:155250
polydactyly J:155250
protruding tongue J:155250
retina coloboma J:155250
short limbs J:155250
short tail J:155250
sirenomelia J:155250
spina bifida J:155250
Lrp6tm1.2Vari/Lrp6tm1.2Vari
involves: 129S1/Sv 		neonatal lethality, complete penetrance J:178499
Lrp6tm1Arma/Lrp6+
C57BL/6-Lrp6tm1Arma 		increased cholesterol level J:210538
increased circulating LDL cholesterol level J:210538
increased circulating triglyceride level J:210538
Lrp6tm1Arma/Lrp6tm1Arma
C57BL/6-Lrp6tm1Arma 		abnormal fatty acids level J:210538
abnormal lipid homeostasis J:210538
abnormal liver morphology J:225450
enlarged liver J:210538
hepatic steatosis J:210538, J:225450
hyperlipidemia J:210538
increased cholesterol level J:210538
increased circulating aspartate transaminase level J:210538
increased circulating bilirubin level J:210538
increased circulating LDL cholesterol level J:210538
increased circulating triglyceride level J:210538
increased circulating VLDL triglyceride level J:210538
increased liver cholesterol level J:210538, J:225450
increased liver triglyceride level J:210538
insulin resistance J:210538
liver fibrosis J:225450
liver inflammation J:225450
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory