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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp6
low density lipoprotein receptor-related protein 6
MGI:1298218
64 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ahi1tm1Jgg/Ahi1+
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal renal tubule morphology J:154321
dilated renal tubule J:154321
increased circulating creatinine level J:154321
kidney cyst J:154321
small kidney J:154321
Ctnnb1Bfc/Ctnnb1+
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6+
either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6) 		abnormal head size J:170646
caudal body truncation J:170646
Ctnnb1Bfc/Ctnnb1+
Lrp6Gw/Lrp6+
either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6) 		abnormal head size J:170646
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6+
involves: 101/H * 129 * BALB/c * C3H 		abnormal head morphology J:170646
kinked tail J:170646
Dkk1tm1Lmgd/Dkk1+
Lrp6Gw/Lrp6Gw
involves: 101/H * 129 * BALB/c * C3H 		abnormal head morphology J:170646
Lrp5tm1.1Vari/Lrp5tm1.1Vari
Lrp6tm1.1Vari/Lrp6tm1.1Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone ossification J:178499
abnormal bone structure J:178499
abnormal cartilage morphology J:178499
abnormal cranium morphology J:178499
abnormal epiphyseal plate morphology J:178499
abnormal limb morphology J:178499
abnormal skeleton morphology J:178499
abnormal trabecular bone morphology J:178499
decreased body size J:178499
ectopic cartilage J:178499
neonatal lethality, complete penetrance J:178499
split sternum J:178499
Lrp5tm1.2Vari/Lrp5tm1.2Vari
Lrp6tm1.1Vari/Lrp6tm1.1Vari
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone ossification J:178499
abnormal bone structure J:178499
abnormal cartilage morphology J:178499
abnormal cranium morphology J:178499
abnormal epiphyseal plate morphology J:178499
abnormal joint morphology J:178499
abnormal limb morphology J:178499
abnormal osteoblast differentiation J:178499
abnormal skeleton morphology J:178499
abnormal trabecular bone morphology J:178499
decreased body size J:178499
decreased width of hypertrophic chondrocyte zone J:178499
ectopic cartilage J:178499
failure of bone ossification J:178499
neonatal lethality, complete penetrance J:178499
split sternum J:178499
Lrp5tm1Jfh/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129S5/SvEvBrd * C57BL/6 		abnormal bone ossification J:91055
forelimb oligodactyly J:91055
Lrp5tm1Jfh/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
involves: 129S5/SvEvBrd * C57BL/6 		abnormal amnion morphology J:91055
abnormal developmental patterning J:91055
abnormal extraembryonic tissue morphology J:91055
abnormal primitive streak formation J:91055
absent somites J:91055
increased forebrain size J:91055
lethality throughout fetal growth and development, complete penetrance J:91055
Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129S5/SvEvBrd * C57BL/6 		absent carpal bone J:91055
absent fibula J:91055
absent metacarpal bones J:91055
decreased body size J:91055
decreased fetal size J:91055
oligodactyly J:91055
postnatal lethality, incomplete penetrance J:91055
Lrp5tm1Jfh/Lrp5tm1Jfh
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
involves: 129S5/SvEvBrd * C57BL/6 		abnormal developmental patterning J:91055
abnormal germ layer development J:91055
abnormal mesoderm development J:91055
absent allantois J:91055
absent amnion J:91055
absent endoderm J:91055
lethality throughout fetal growth and development, complete penetrance J:91055
Lrp5tm1Lex/Lrp5+
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N 		abnormal forelimb morphology J:111359
abnormal limb morphology J:111359
decreased bone mass J:111359
decreased bone mineral density J:111359
forelimb oligodactyly J:111359
synostosis J:111359
Lrp5tm1Lex/Lrp5tm1Lex
Lrp6Gt(Ex187)Byg/Lrp6+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N 		abnormal carpal bone morphology J:111359
abnormal cranium morphology J:111359
abnormal forelimb morphology J:111359
abnormal hindlimb morphology J:111359
abnormal limb morphology J:111359
abnormal tarsal bone morphology J:111359
decreased bone mass J:111359
decreased bone mineral density J:111359
forelimb oligodactyly J:111359
monodactyly J:111359
synostosis J:111359
Lrp5tm1Lex/Lrp5tm1Lex
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N 		decreased bone mineral density J:111359
Lrp6Gt(Ex187)Byg/Lrp6+
Wnt3avt/Wnt3a+
involves: 129P2/OlaHsd * C57BL/6 * C57BR 		kinked tail J:64989
Lrp6Gt(Ex187)Byg/Lrp6+
Wnt3avt/Wnt3avt
involves: 129P2/OlaHsd * C57BL/6 * C57BR 		vestigial tail J:64989
Lrp6Gt(Ex187)Byg/Lrp6+
Rspo2tm1Nuv/Rspo2tm1Nuv
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal craniofacial morphology J:171482
cleft palate J:171482
cleft upper lip J:171482
decreased cranium height J:171482
short mandible J:171482
short maxilla J:171482
short Meckel's cartilage J:171482
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Rspo2tm1Nuv/Rspo2tm1Nuv
involves: 129 * 129P2/OlaHsd * C57BL/6 		prenatal lethality, complete penetrance J:171482
Lrp6Gw/Lrp6+
Wnt3tm1Brd/Wnt3+
involves: 101/H * 129S7/SvEvBrd * BALB/c * C3H 		kinked tail J:170646
Lrp6skax26/Lrp6+
Vangl2Lp/Vangl2+
involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J 		abnormal orientation of outer hair cell stereociliary bundles J:206979
curly tail J:206979
kinked tail J:206979
spina bifida J:206979
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory