Pip5k1c Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
MGI:1298224

37 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myl2^tm1(cre)Krc/Myl2⁺ Pip5k1c^tm2Csab/Pip5k1c^tm2Csab Not Specified	abnormal platelet aggregation	J:196476
	abnormal platelet physiology	J:196476
Pip5k1c^Gt(XD096)Byg/Pip5k1c^Gt(XD096)Byg involves: 129P2/OlaHsd	abnormal cardinal vein morphology	J:131432
	abnormal embryonic neuroepithelium morphology	J:131432
	abnormal fetal cardiomyocyte morphology	J:131432
	abnormal heart right ventricle morphology	J:131432
	abnormal interventricular septum morphology	J:131432
	abnormal megakaryocyte morphology	J:131289
	abnormal spinal cord morphology	J:131432
	decreased embryo size	J:131432
	decreased neuronal migration	J:131432
	distended pericardium	J:131432
	embryonic lethality during organogenesis, complete penetrance	J:131432
	exencephaly	J:131432
	incomplete rostral neuropore closure	J:131432
	pericardial effusion	J:131432
Pip5k1c^tm1.1Ref/Pip5k1c^tm1.1Ref involves: 129	normal cellular phenotype	J:200273
Pip5k1c^tm1.2Ref/Pip5k1c^tm1.2Ref involves: 129	abnormal cell physiology	J:200273
	abnormal synaptic vesicle recycling	J:200273
	decreased startle reflex	J:200273
	normal mortality/aging	J:200273
Pip5k1c^{tm1b(KOMP)Wtsi}/Pip5k1c⁺ C57BL/6N-Pip5k1c^{tm1b(KOMP)Wtsi}/J	decreased grip strength	J:211773
	increased circulating alkaline phosphatase level	J:211773
	persistence of hyaloid vascular system	J:211773
Pip5k1c^{tm1b(KOMP)Wtsi}/Pip5k1c^{tm1b(KOMP)Wtsi} C57BL/6N-Pip5k1c^{tm1b(KOMP)Wtsi}/J	edema	J:211773
	preweaning lethality, complete penetrance	J:211773
Pip5k1c^tm1Csab/Pip5k1c^tm1Csab Tg(Pf4-icre)Q3Rsko/0 Not Specified	abnormal platelet physiology	J:196476
Pip5k1c^tm1Pdc/Pip5k1c⁺ involves: C57BL/6	abnormal glutamate-mediated receptor currents	J:92666
Pip5k1c^tm1Pdc/Pip5k1c^tm1Pdc involves: C57BL/6	abnormal CNS synaptic transmission	J:92666
	abnormal inhibitory postsynaptic currents	J:92666
	abnormal locomotor behavior	J:92666
	abnormal miniature excitatory postsynaptic currents	J:92666
	absent gastric milk in neonates	J:92666
	impaired synaptic plasticity	J:92666
	increased synaptic depression	J:92666
	neonatal lethality, complete penetrance	J:92666
Pip5k1c^tm2.1Ref/Pip5k1c^tm2.1Ref B6.129-Pip5k1c^tm2.1Ref	abnormal cell physiology	J:200273
	abnormal synaptic vesicle recycling	J:200273
	absent gastric milk in neonates	J:200273
	normal integument phenotype	J:200273
	neonatal lethality, complete penetrance	J:200273
Pip5k1c^tm2.2Ref/Pip5k1c^tm2.2Ref involves: 129 * C57BL/6	normal cellular phenotype	J:200273
Pip5k1c^tm2.2Ref/Pip5k1c^tm2.2Ref Tg(KRT5-cre)5132Jlj/0 involves: 129 * C57BL/6 * C57BL/6J * DBA/2J	no abnormal phenotype detected	J:200273

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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