Pip5k1c Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
MGI:1298224

37 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myl2^tm1(cre)Krc/Myl2⁺ Pip5k1c^tm2Csab/Pip5k1c^tm2Csab Not Specified	abnormal platelet aggregation	J:196476
	abnormal platelet physiology	J:196476
Pip5k1c^Gt(XD096)Byg/Pip5k1c^Gt(XD096)Byg involves: 129P2/OlaHsd	abnormal cardinal vein morphology	J:131432
	abnormal embryonic neuroepithelium morphology	J:131432
	abnormal fetal cardiomyocyte morphology	J:131432
	abnormal heart right ventricle morphology	J:131432
	abnormal interventricular septum morphology	J:131432
	abnormal megakaryocyte morphology	J:131289
	abnormal neuronal migration	J:131432
	abnormal spinal cord morphology	J:131432
	decreased embryo size	J:131432
	distended pericardium	J:131432
	embryonic lethality during organogenesis, complete penetrance	J:131432
	exencephaly	J:131432
	incomplete rostral neuropore closure	J:131432
	pericardial effusion	J:131432
Pip5k1c^tm1.1Ref/Pip5k1c^tm1.1Ref involves: 129	normal cellular phenotype	J:200273
Pip5k1c^tm1.2Ref/Pip5k1c^tm1.2Ref involves: 129	abnormal cell physiology	J:200273
	abnormal synaptic vesicle recycling	J:200273
	decreased startle reflex	J:200273
	normal mortality/aging	J:200273
Pip5k1c^{tm1b(KOMP)Wtsi}/Pip5k1c⁺ C57BL/6N-Pip5k1c^{tm1b(KOMP)Wtsi}/J	decreased grip strength	J:211773
	increased circulating alkaline phosphatase level	J:211773
	persistence of hyaloid vascular system	J:211773
Pip5k1c^{tm1b(KOMP)Wtsi}/Pip5k1c^{tm1b(KOMP)Wtsi} C57BL/6N-Pip5k1c^{tm1b(KOMP)Wtsi}/J	edema	J:211773
	preweaning lethality, complete penetrance	J:211773
Pip5k1c^tm1Csab/Pip5k1c^tm1Csab Tg(Pf4-icre)Q3Rsko/0 Not Specified	abnormal platelet physiology	J:196476
Pip5k1c^tm1Pdc/Pip5k1c⁺ involves: C57BL/6	abnormal glutamate-mediated receptor currents	J:92666
Pip5k1c^tm1Pdc/Pip5k1c^tm1Pdc involves: C57BL/6	abnormal CNS synaptic transmission	J:92666
	abnormal inhibitory postsynaptic currents	J:92666
	abnormal locomotor behavior	J:92666
	abnormal miniature excitatory postsynaptic currents	J:92666
	absent gastric milk in neonates	J:92666
	impaired synaptic plasticity	J:92666
	increased synaptic depression	J:92666
	neonatal lethality, complete penetrance	J:92666
Pip5k1c^tm2.1Ref/Pip5k1c^tm2.1Ref B6.129-Pip5k1c^tm2.1Ref	abnormal cell physiology	J:200273
	abnormal synaptic vesicle recycling	J:200273
	absent gastric milk in neonates	J:200273
	normal integument phenotype	J:200273
	neonatal lethality, complete penetrance	J:200273
Pip5k1c^tm2.2Ref/Pip5k1c^tm2.2Ref involves: 129 * C57BL/6	normal cellular phenotype	J:200273
Pip5k1c^tm2.2Ref/Pip5k1c^tm2.2Ref Tg(KRT5-cre)5132Jlj/0 involves: 129 * C57BL/6 * C57BL/6J * DBA/2J	no abnormal phenotype detected	J:200273

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/09/2024 MGI 6.24