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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nck2
non-catalytic region of tyrosine kinase adaptor protein 2
MGI:1306821
31 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Unc/Apoetm1Unc
Nck1tm1Paw/Nck1tm1Paw
Nck2tm3Paw/Nck2tm3Paw
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased inflammatory response J:326659
decreased susceptibility to diet-induced aortic fatty streak lesions J:326659
Nck1tm1Paw/Nck1tm1Paw
Nck2tm1Paw/Nck2tm1Paw
involves: 129/Ola * ICR 		abnormal allantois morphology J:83956
abnormal cell physiology J:83956
abnormal developmental patterning J:83956
abnormal embryonic tissue morphology J:83956
abnormal extraembryonic tissue morphology J:83956
abnormal neural tube morphology J:83956
dilated allantois J:83956
embryonic lethality during organogenesis, complete penetrance J:83956
failure of chorioallantoic fusion J:83956
incomplete rostral neuropore closure J:83956
notochord degeneration J:83956
wavy neural tube J:83956
Nck1tm1Paw/Nck1tm1Paw
Nck2tm1Paw/Nck2tm3Paw
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal axon guidance J:129166
abnormal brain commissure morphology J:129166
abnormal central pattern generator function J:129166
abnormal gait J:129166
abnormal spinal cord dorsal column morphology J:129166
abnormal spinal cord grey matter morphology J:129166
ataxia J:129166
decreased body size J:129166
postnatal lethality, complete penetrance J:129166
Nck1tm1Paw/Nck1tm1Paw
Nck2tm3Paw/Nck2tm3Paw
Tg(Nphs2-cre)1Seq/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal glomerular filtration barrier function J:107630
abnormal podocyte foot process morphology J:107630
abnormal podocyte morphology J:107630
abnormal renal glomerulus morphology J:107630
albuminuria J:107630
decreased body size J:107630
fused podocyte foot processes J:107630
glomerulosclerosis J:107630
renal cast J:107630
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory