Casp12 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Casp12
caspase 12
MGI:1312922

11 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Casp12^tm1Dgen/Casp12^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679
Casp12^tm1Dwni/Casp12^tm1Dwni involves: 129S1/SvImJ * C57BL/6	decreased susceptibility to bacterial infection	J:144912
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:144912
	increased circulating interleukin-18 level	J:144912
	increased interferon-gamma secretion	J:144912
	increased interleukin-1 beta secretion	J:144912
	increased susceptibility to endotoxin shock	J:144912
Casp12^tm1Yuan/Casp12^tm1Yuan involves: 129S4/SvJae * C57BL/6J	normal cellular phenotype	J:59337
	decreased sensitivity to induced cell death	J:59337
	decreased susceptibility to neuronal excitotoxicity	J:59337
	normal neoplasm	J:59337

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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