Cldn4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cldn4
claudin 4
MGI:1313314

26 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cldn4^tm1.1Jhou/Cldn4^tm1.1Jhou Tg(Aqp2-cre)1Dek/0 B6.Cg-Cldn4^tm1.1Jhou Tg(Aqp2-cre)1Dek	abnormal renal reabsorption	J:216399
	abnormal renal sodium reabsorption	J:216399
	alkalosis	J:216399
	decreased body weight	J:216399
	decreased circulating chloride level	J:216399
	decreased mean systemic arterial blood pressure	J:216399
	increased circulating aldosterone level	J:216399
	increased circulating bicarbonate level	J:216399
	increased circulating potassium level	J:216399
	increased hematocrit	J:216399
	increased urine chloride ion level	J:216399
	increased urine sodium level	J:216399
	polyuria	J:216399
Cldn4^tm1.1Yham/Cldn4^tm1.1Yham B6.129S2-Cldn4^tm1.1Yham	abnormal kidney pelvis urothelium morphology	J:195766
	abnormal renal calcium reabsorption	J:195766
	abnormal renal reabsorption	J:195766
	abnormal renal/urinary system morphology	J:195766
	abnormal ureter physiology	J:195766
	decreased circulating calcium level	J:195766
	normal homeostasis/metabolism phenotype	J:195766
	hydronephrosis	J:195766
	increased kidney cell proliferation	J:195766
	increased urine calcium level	J:195766
	increased urine chloride ion level	J:195766
	premature death	J:195766
	normal renal/urinary system phenotype	J:195766
	ureter urothelium hyperplasia	J:195766
Cldn4^tm1.1Zboro/Cldn4^tm1.1Zboro involves: 129S4/SvJaeSor * 129S6/SvEvTac	no abnormal phenotype detected	J:216793

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24