Rasgrp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rasgrp1
RAS guanyl releasing protein 1
MGI:1314635

55 phenotypes from 10 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rasgrp1^lag/Rasgrp1^lag involves: 129 * C57BL/6	abnormal lymph node morphology	J:85189
	abnormal positive T cell selection	J:85189
	abnormal renal glomerular capsule morphology	J:85189
	abnormal renal glomerulus morphology	J:85189
	abnormal T cell physiology	J:85189
	decreased T cell proliferation	J:85189
	enlarged liver	J:85189
	enlarged lymph nodes	J:85189
	enlarged spleen	J:85189
	glomerulonephritis	J:85189
	increased B cell number	J:85189
	increased IgG level	J:85189
	increased susceptibility to systemic lupus erythematosus	J:85189
	increased T cell number	J:85189
Rasgrp1^m1Anu/Rasgrp1⁺ involves: C57BL/6JSfdAnu * CBA/J	increased anti-nuclear antigen antibody level	J:207898
Rasgrp1^m1Anu/Rasgrp1^m1Anu C57BL/6JSfdAnu-Rasgrp1^m1Anu	abnormal T cell differentiation	J:104190
Rasgrp1^m1Anu/Rasgrp1^m1Anu C57BL/6JSfdAnu-Rasgrp1^m1Anu	autoimmune response	J:104190
Rasgrp1^m1Anu/Rasgrp1^m1Anu involves: C57BL/6JSfdAnu * CBA/J	abnormal CD4-positive, alpha beta T cell morphology	J:207898
	normal immune system phenotype	J:207898
	increased anti-nuclear antigen antibody level	J:207898
	increased effector memory CD4-positive, alpha-beta T cell number	J:207898
Rasgrp1^m1Btlr/Rasgrp1^m1Btlr C57BL/6J-Rasgrp1^m1Btlr	abnormal humoral immune response	J:265163
	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:265163
	decreased CD8-positive, naive alpha-beta T cell number	J:265163
	decreased IgM level	J:265163
	increased CD8-positive, alpha-beta memory T cell number	J:265163
	increased effector memory CD4-positive, alpha-beta T cell number	J:265163
	increased IgA level	J:265163
	increased IgE level	J:265163
	increased IgM level	J:265163
	increased NK cell number	J:265163
Rasgrp1^m2Anu/Rasgrp1^m2Anu C57BL/6NCrlAnu-Rasgrp1^m2Anu	normal immune system phenotype	J:104190
Rasgrp1^m2Btlr/Rasgrp1^m2Btlr C57BL/6J-Rasgrp1^m2Btlr	decreased CD4-positive, alpha-beta T cell number	J:265163
	decreased CD8-positive, alpha-beta T cell number	J:265163
	decreased CD8-positive, naive alpha-beta T cell number	J:265163
	decreased single-positive T cell number	J:265163
	decreased T cell number	J:265163
	increased central memory CD4-positive, alpha-beta T cell number	J:265163
	increased central memory CD8 positive, alpha-beta T cell number	J:265163
	increased effector memory CD4-positive, alpha-beta T cell number	J:265163
	increased effector memory CD8-positive, alpha-beta T cell number	J:265163
	increased NK cell number	J:265163
Rasgrp1^m3Btlr/Rasgrp1^m3Btlr C57BL/6J-Rasgrp1^m3Btlr	decreased CD4-positive, alpha-beta T cell number	J:265255
	decreased CD8-positive, alpha-beta T cell number	J:265255
	decreased CD8-positive, naive alpha-beta T cell number	J:265255
	decreased single-positive T cell number	J:265255
	decreased T cell number	J:265255
	increased B cell number	J:265255
	increased B-1b cell number	J:265255
	increased central memory CD8 positive, alpha-beta T cell number	J:265255
	increased effector memory CD4-positive, alpha-beta T cell number	J:265255
	increased effector memory CD8-positive, alpha-beta T cell number	J:265255
	increased IgM level	J:265255
	increased neutrophil cell number	J:265255
	increased NK cell number	J:265255
Rasgrp1^M4Btlr/Rasgrp1^M4Btlr C57BL/6J-Rasgrp1^M4Btlr	abnormal T cell morphology	J:267490
Rasgrp1^m5Btlr/Rasgrp1^m5Btlr C57BL/6J-Rasgrp1^m5Btlr	increased NK cell number	J:272846
Rasgrp1^tm1.1Wz/Rasgrp1^tm1.1Wz B6.Cg-Rasgrp1^tm1.1Wz	abnormal CD4-positive T cell differentiation	J:225109
	abnormal CD8-positive, alpha-beta T cell differentiation	J:225109
	abnormal immune system cell morphology	J:225109
	abnormal immune system organ morphology	J:225109
	abnormal immune system physiology	J:225109
	abnormal immunoglobulin level	J:225109
	abnormal T cell differentiation	J:225109
	decreased single-positive T cell number	J:225109
	decreased T cell proliferation	J:225109
	enlarged spleen	J:225109
	normal immune system phenotype	J:225109
	increased autoantibody level	J:225109
	increased CD4-positive, alpha-beta memory T cell number	J:225109
	increased IgE level	J:225109
	increased IgG1 level	J:225109
	increased single-positive T cell number	J:225109
	increased spleen weight	J:225109
Rasgrp1^tm1Jstn/Rasgrp1^tm1Jstn involves: 129P3/J	abnormal CD4-positive, alpha beta T cell morphology	J:207898
	abnormal double-positive T cell morphology	J:207898
	decreased CD4-positive, alpha-beta T cell number	J:207898
	decreased CD8-positive, alpha-beta T cell number	J:207898
Rasgrp1^tm1Jstn/Rasgrp1^tm1Jstn involves: 129P3/J * C57BL/6J	abnormal humoral immune response	J:108677
	decreased B cell number	J:108677
	decreased thymocyte number	J:108677
	enlarged spleen	J:108677
	increased immunoglobulin level	J:108677
	increased plasma cell number	J:108677

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