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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Afdn
afadin, adherens junction formation factor
MGI:1314653
59 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Afdnem1(IMPC)Mbp/Afdn+
C57BL/6N-Afdnem1(IMPC)Mbp/MbpMmucd 		abnormal cecum morphology J:211773
abnormal gallbladder morphology J:211773
abnormal hindbrain development J:211773
abnormal kidney morphology J:211773
abnormal liver morphology J:211773
abnormal lymph node morphology J:211773
abnormal neural tube closure J:211773
abnormal neural tube morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal urinary bladder morphology J:211773
abnormal uterus morphology J:211773
cystolithiasis J:211773
decreased lymphocyte cell number J:211773
decreased prepulse inhibition J:211773
decreased spleen weight J:211773
enlarged kidney J:211773
enlarged liver J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
small spleen J:211773
Afdnem1(IMPC)Mbp/Afdnem1(IMPC)Mbp
C57BL/6N-Afdnem1(IMPC)Mbp/MbpMmucd 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Afdntm1.1Lfr/Afdntm1.1Lfr
Neurod6tm1(cre)Kan/Neurod6+
involves: 129 * C57BL/6 * SJL 		abnormal excitatory postsynaptic potential J:179366
abnormal hippocampus CA1 region morphology J:179366
abnormal hippocampus pyramidal cell morphology J:179366
abnormal synapse morphology J:179366
ectopic hippocampus pyramidal cells J:179366
Afdntm1c(EUCOMM)Hmgu/Afdntm1c(EUCOMM)Hmgu
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * C57BL/6J * C57BL/6N 		abnormal cell cycle J:215584
abnormal cerebral cortex morphology J:215584
abnormal cortical ventricular zone morphology J:215584
abnormal embryonic neuroepithelium morphology J:215584
abnormal hippocampus morphology J:215584
abnormal neocortex morphology J:215584
abnormal nervous system tract morphology J:215584
abnormal radial glial cell morphology J:215584
abnormal stratification in cerebral cortex J:215584
abnormal telencephalon development J:215584
ectopic neuron J:215584
increased brain size J:215584
increased neocortex size J:215584
increased neuronal precursor cell number J:215584
increased radial glial cell number J:215584
thin cortical plate J:215584
Afdntm1Mrcr/Afdntm1Mrcr
involves: 129S1/Sv * 129X1/SvJ 		abnormal ectoderm development J:57046
abnormal embryonic neuroepithelium morphology J:57046
abnormal germ layer development J:57046
abnormal mesoderm development J:57046
abnormal rostral-caudal body axis extension J:57046
absent allantois J:57046
absent neural folds J:57046
absent notochord J:57046
absent somites J:57046
decreased embryo size J:57046
embryonic growth arrest J:57046
embryonic lethality during organogenesis, complete penetrance J:57046
Afdntm1Ytk/Afdntm1Ytk
involves: 129X1/SvJ * C57BL/6 * DBA/2 		abnormal amniotic cavity morphology J:57589
abnormal ectoderm development J:57589
abnormal extraembryonic coelom morphology J:57589
abnormal mesoderm development J:57589
abnormal neural tube morphology J:57589
abnormal somite development J:57589
absent allantois J:57589
absent heart J:57589
decreased embryo size J:57589
embryonic lethality during organogenesis, complete penetrance J:57589
Afdntm2Ytk/Afdntm2Ytk
Tg(Camk2a-cre)1Gsc/0
involves: FVB/N 		abnormal synapse morphology J:151436
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory