Hipk2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hipk2
homeodomain interacting protein kinase 2
MGI:1314872

29 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hipk2^tm1Afus/Hipk2^tm1Afus involves: 129X1/SvJ * C57BL/6	abnormal cell cycle	J:156574
	abnormal motor capabilities/coordination/movement	J:156574
	decreased birth weight	J:156574
	decreased body weight	J:156574
	decreased cell proliferation	J:156574
	limb grasping	J:156574
Hipk2^tm1Ejh/Hipk2^tm1Ejh involves: 129X1/SvJ * C57BL/6	abnormal gait	J:117465
	abnormal response to novelty	J:117465
	abnormal voluntary movement	J:117465
	decreased dopamine level	J:117465
	decreased dopaminergic neuron number	J:117465
	decreased exploration in new environment	J:117465
	decreased neuron apoptosis	J:117465
	decreased substantia nigra size	J:117465
	decreased tegmentum size	J:117465
	dystonia	J:117465
	impaired behavioral response to addictive substance	J:117465
	impaired coordination	J:117465
	limb grasping	J:117465
	short stride length	J:117465
Hipk2^tm1Ejh/Hipk2^tm1Ejh involves: 129X1/SvJ * C57BL/6J	enlarged trigeminal ganglion	J:93311
Hipk2^tm1Hko/Hipk2^tm1Hko involves: C57BL/6	abnormal neural tube morphology	J:106931
Hipk2^tm1Hko/Hipk2^tm1Hko involves: C57BL/6	decreased cellular sensitivity to ultraviolet irradiation	J:106931
Hipk2^{tm2b(EUCOMM)Hmgu}/Hipk2⁺ C57BL/6N-Hipk2^{tm2b(EUCOMM)Hmgu}/Cnrm	increased heart weight	J:211773
	increased kidney weight	J:211773
Hipk2^{tm2b(EUCOMM)Hmgu}/Hipk2^{tm2b(EUCOMM)Hmgu} C57BL/6N-Hipk2^{tm2b(EUCOMM)Hmgu}/Cnrm	abnormal lens morphology	J:211773
	abnormal maxilla morphology	J:211773
	abnormal snout morphology	J:211773
	abnormal tooth morphology	J:211773
	preweaning lethality, incomplete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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