Chaf1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chaf1b
chromatin assembly factor 1, subunit B
MGI:1314881

14 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chaf1b^{tm1b(EUCOMM)Hmgu}/Chaf1b⁺ C57BL/6N-Chaf1b^{tm1b(EUCOMM)Hmgu}/Ieg	decreased circulating calcium level	J:211773
	decreased circulating total protein level	J:211773
	increased circulating amylase level	J:211773
	increased circulating lipase level	J:211773
Chaf1b^{tm1b(EUCOMM)Hmgu}/Chaf1b^{tm1b(EUCOMM)Hmgu} C57BL/6N-Chaf1b^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Chaf1b^{tm2c(EUCOMM)Hmgu}/Chaf1b⁺ Tg(Mx1-cre)1Cgn/0 involves: C57BL/6J * C57BL/6N * CBA/J	abnormal bone marrow cell morphology/development	J:266848
	abnormal bone marrow cell physiology	J:266848
	decreased bone marrow cell number	J:266848
	decreased hematopoietic stem cell number	J:266848
	increased apoptosis	J:266848
Chaf1b^{tm2c(EUCOMM)Hmgu}/Chaf1b⁺ Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca	abnormal bone marrow cell morphology/development	J:266848
	decreased bone marrow cell number	J:266848
	decreased hematopoietic stem cell number	J:266848
Chaf1b^{tm2c(EUCOMM)Hmgu}/Chaf1b^{tm2c(EUCOMM)Hmgu} Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca	prenatal lethality, complete penetrance	J:266848
Chaf1b^{tm2c(EUCOMM)Hmgu}/Chaf1b^{tm2c(EUCOMM)Hmgu} Tg(Mx1-cre)1Cgn/0 involves: C57BL/6J * C57BL/6N * CBA/J	abnormal bone marrow cell morphology/development	J:266848
	abnormal bone marrow cell physiology	J:266848
	decreased bone marrow cell number	J:266848
	decreased hematopoietic cell number	J:266848
	decreased hematopoietic stem cell number	J:266848
	increased apoptosis	J:266848
	pancytopenia	J:266848
	premature death	J:266848

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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