About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfrsf1b
tumor necrosis factor receptor superfamily, member 1b
MGI:1314883
72 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL 		embryonic lethality during organogenesis, complete penetrance J:182515
Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		abnormal lymph node cortex morphology J:119206
abnormal lymph node primary follicle morphology J:119206
abnormal lymph node secondary follicle morphology J:119206
absent lymph node germinal center J:119206
absent spleen germinal center J:119206
increased eosinophil cell number J:119206
increased leukocyte cell number J:119206
increased lymphocyte cell number J:119206
increased susceptibility to fungal infection J:119206
lung inflammation J:119206
small Peyer's patches J:119206
Krt8tm1Rgo/Krt8tm1Rgo
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6 * FVB/N 		embryonic lethality during organogenesis, incomplete penetrance J:121811
Lepob/Lepob
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * C57BL/6 		abnormal adipose tissue morphology J:55722
abnormal metabolism J:55722
decreased circulating insulin level J:55722
Tg(INS-Il10)#Sar/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6J * NOD 		increased circulating glucose level J:64051
increased susceptibility to autoimmune diabetes J:64051
Tg(Tnf)6074Gkl/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal oligodendrocyte apoptosis J:106592
CNS inflammation J:106592
demyelination J:106592
Tnftm2Gkl/Tnf+
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		rheumatoid arthritis J:54056
small intestinal inflammation J:54056
Tnftm2Gkl/Tnf+
Tnfrsf1btm1.1Gkl/Tnfrsf1btm1.1Gkl
Tg(Col6a1-cre)1Gkl/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA 		abnormal cell adhesion J:264147
abnormal cell physiology J:264147
abnormal fibroblast physiology J:264147
abnormal wound healing J:264147
normal cardiovascular system phenotype J:264147
increased circulating tumor necrosis factor level J:264147
increased tumor necrosis factor secretion J:264147
joint inflammation J:264147
Tnftm2Gkl/Tnf+
Tnfrsf1btm1.2Gkl/Tnfrsf1btm1.2Gkl
involves: 129S/SvEv * C57BL/6 * C57BL/6J 		abnormal cell adhesion J:264147
abnormal cell physiology J:264147
abnormal fibroblast physiology J:264147
abnormal wound healing J:264147
aortic valve inflammation J:264147
aortic valve stenosis J:264147
autoimmune arthritis J:264147
cardiac fibrosis J:264147
increased circulating tumor necrosis factor level J:264147
increased tumor necrosis factor secretion J:264147
Tnfaip8l1em1Huwa/Tnfaip8l1em1Huwa
Tnfrsf1aem2Smoc/Tnfrsf1aem2Smoc
Tnfrsf1bem1Smoc/Tnfrsf1bem1Smoc
C57BL/6-Tnfrsf1bem1Smoc Tnfrsf1aem2Smoc Tnfaip8l1em1Huwa 		normal digestive/alimentary phenotype J:342074
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129/Sv * C57BL/6 		liver inflammation J:92470
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal lymph node cortex morphology J:119206
abnormal lymph node primary follicle morphology J:119206
abnormal lymph node secondary follicle morphology J:119206
absent lymph node germinal center J:119206
absent spleen germinal center J:119206
decreased IgG1 level J:115225
decreased susceptibility to experimental autoimmune encephalomyelitis J:115225
normal immune system phenotype J:119206
increased susceptibility to parasitic infection J:114203
small Peyer's patches J:119206
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
B6.129S-Tnfrsf1btm1Imx Tnfrsf1atm1Imx/J 		decreased susceptibility to Coronaviridae infection J:288523
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * C57BL/6 		abnormal body temperature homeostasis J:48865
abnormal bone healing J:70467
abnormal glial cell physiology J:78637
abnormal kidney morphology J:69294
abnormal nervous system morphology J:78637
abnormal neuron physiology J:33864
abnormal retina blood vessel morphology J:104652
abnormal thrombosis J:117987
abnormal trabecular bone morphology J:70467
decreased food intake J:48865
decreased inflammatory response J:45147
decreased microglial cell activation J:33864
decreased physiological sensitivity to xenobiotic J:51349
decreased susceptibility to dopaminergic neuron neurotoxicity J:78637
decreased susceptibility to endotoxin shock J:45147
decreased susceptibility to experimental autoimmune uveoretinitis J:115094
decreased susceptibility to induced arthritis J:120707
decreased susceptibility to induced morbidity/mortality J:48865
dental pulp necrosis J:58851
impaired skeletal muscle regeneration J:104990
increased bone resorption J:58851
increased cerebral infarct size J:33864
increased circulating tumor necrosis factor level J:45147
increased myocardial infarct size J:62223
increased susceptibility to bacterial infection J:58851
increased susceptibility to neuronal excitotoxicity J:33864
normal nervous system phenotype J:33864
osteomyelitis J:58851
pulmonary fibrosis J:51349
renal interstitial fibrosis J:69294
seizures J:112713
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory