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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
MGI:1314884
74 phenotypes from 11 alleles in 21 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tnfrsf1aem1(IMPC)Ccpcz/Tnfrsf1aem1(IMPC)Ccpcz
C57BL/6NCrl-Tnfrsf1aem1(IMPC)Ccpcz/Ccpcz 		abnormal heart morphology J:211773
abnormal skin morphology J:211773
enlarged heart J:211773
increased circulating aspartate transaminase level J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased neutrophil cell number J:211773
increased NK cell number J:211773
Tnfrsf1atm1.1Gkl/Tnfrsf1a+
involves: 129/Sv * C57BL/6 		increased susceptibility to induced morbidity/mortality J:92470
liver inflammation J:92470
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129/Sv * C57BL/6 		abnormal cytokine secretion J:92470
decreased susceptibility to bacterial infection J:92470
increased susceptibility to experimental autoimmune encephalomyelitis J:92470
increased susceptibility to induced morbidity/mortality J:92470
liver inflammation J:92470
Tnfrsf1atm1Blt/Tnfrsf1a+
involves: 129P2/OlaHsd 		abnormal response/metabolism to endogenous compounds J:210950
decreased circulating interleukin-6 level J:210950
decreased susceptibility to induced morbidity/mortality J:210950
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
B6.129P2-Tnfrsf1atm1Blt 		abnormal sleep pattern J:103266
impaired central nervous system regeneration J:71178
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
C.129P2-Tnfrsf1atm1Blt 		decreased physiological sensitivity to xenobiotic J:87476
decreased susceptibility to xenobiotic induced morbidity/mortality J:87476
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		decreased circulating alanine transaminase level J:50903
decreased susceptibility to bacterial infection J:50903
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
involves: 129P2/OlaHsd 		abnormal response/metabolism to endogenous compounds J:210950
decreased susceptibility to induced morbidity/mortality J:210950
impaired humoral immune response J:210950
increased sensitivity to induced cell death J:210950
increased susceptibility to bacterial infection induced morbidity/mortality J:210950
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
involves: 129P2/OlaHsd * C57BL/6 		abnormal immune system physiology J:14424
abnormal lymph node B cell domain morphology J:40970
abnormal Peyer's patch follicle morphology J:40970
abnormal Peyer's patch morphology J:40970
absent follicular dendritic cells J:40970
decreased IgG1 level J:115225
decreased interleukin-6 secretion J:14424
decreased Peyer's patch number J:40970
decreased susceptibility to experimental autoimmune encephalomyelitis J:115225
increased susceptibility to bacterial infection J:14424
increased susceptibility to parasitic infection J:114203
increased susceptibility to type I hypersensitivity reaction J:92307
Tnfrsf1atm1Blt/Tnfrsf1atm2Gkl
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * 129S/SvEv 		normal immune system phenotype J:113314
Tnfrsf1atm1Imx/Tnfrsf1a+
involves: C57BL/6 		abnormal response/metabolism to endogenous compounds J:210950
decreased circulating interleukin-6 level J:210950
decreased susceptibility to induced morbidity/mortality J:210950
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
C57BL/6-Tnfrsf1atm1Imx 		abnormal airway responsiveness J:120174, J:143836
abnormal glutamate-mediated receptor currents J:152590
abnormal nervous system physiology J:112713
abnormal neuron proliferation J:112713
abnormal oval cell physiology J:66448
abnormal respiratory mechanics J:143836
decreased inflammatory response J:45147
decreased microglial cell number J:112713
decreased susceptibility to dopaminergic neuron neurotoxicity J:78637
decreased susceptibility to endotoxin shock J:45147
decreased tumor incidence J:66448
increased circulating tumor necrosis factor level J:45147
increased skin papilloma incidence J:89088
increased susceptibility to bacterial infection J:45147
lung inflammation J:120174
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
C57BL/6-Tnfrsf1atm1Imx/J 		abnormal chemokine secretion J:160543
abnormal follicular dendritic cell morphology J:160543
abnormal macrophage physiology J:160543
decreased circulating interleukin-6 level J:160543
decreased interleukin-6 secretion J:160543
decreased susceptibility to endotoxin shock J:160543
decreased susceptibility to induced morbidity/mortality J:160543
increased circulating tumor necrosis factor level J:160543
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: 129S7/SvEvBrd * C57BL/6 		abnormal immune system physiology J:45147
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
involves: C57BL/6 		abnormal response/metabolism to endogenous compounds J:210950
decreased susceptibility to induced morbidity/mortality J:210950
impaired humoral immune response J:210950
increased sensitivity to induced cell death J:173568
increased susceptibility to bacterial infection induced morbidity/mortality J:210950
Tnfrsf1atm1Mak/Tnfrsf1a+
involves: 129S2/SvPas 		abnormal response/metabolism to endogenous compounds J:210950
decreased circulating interleukin-6 level J:210950
decreased susceptibility to induced morbidity/mortality J:210950
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas 		abnormal response/metabolism to endogenous compounds J:210950
abnormal spleen germinal center morphology J:139030
decreased circulating interleukin-6 level J:138824
decreased IgG level J:139030
decreased susceptibility to bacterial infection J:4753, J:121930
decreased susceptibility to induced morbidity/mortality J:210950
impaired humoral immune response J:210950
impaired skin barrier function J:59056
increased bone mineral density J:135519
increased circulating tumor necrosis factor level J:139030
increased sensitivity to induced cell death J:210950
increased susceptibility to bacterial infection induced morbidity/mortality J:4753, J:139030, J:210950
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6J * DBA/2J 		granulomatous inflammation J:55889
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6J * NOD 		decreased susceptibility to autoimmune diabetes J:64051
Tnfrsf1atm1Rsie/Tnfrsf1a+
B6.Cg-Tnfrsf1atm1Rsie 		impaired adaptive thermogenesis J:160543
increased circulating tumor necrosis factor level J:160543
increased interleukin-6 secretion J:160543
increased susceptibility to endotoxin shock J:160543
increased susceptibility to induced morbidity/mortality J:160543
Tnfrsf1atm1Rsie/Tnfrsf1atm1Rsie
B6.Cg-Tnfrsf1atm1Rsie 		abnormal chemokine secretion J:160543
abnormal follicular dendritic cell morphology J:160543
abnormal macrophage physiology J:160543
decreased circulating interleukin-1 beta level J:160543
decreased circulating interleukin-6 level J:160543
decreased interleukin-6 secretion J:160543
decreased susceptibility to endotoxin shock J:160543
decreased susceptibility to induced morbidity/mortality J:160543
increased circulating tumor necrosis factor level J:160543
Tnfrsf1atm2.1Rsie/Tnfrsf1a+
B6.Cg-Tnfrsf1atm2.1Rsie 		abnormal macrophage physiology J:160543
decreased circulating interleukin-1 beta level J:160543
decreased circulating interleukin-6 level J:160543
decreased interleukin-6 secretion J:160543
increased interleukin-6 secretion J:160543
increased susceptibility to endotoxin shock J:160543
increased susceptibility to induced morbidity/mortality J:160543
Tnfrsf1atm2.1Rsie/Tnfrsf1a+
involves: 129S6/SvEvTac 		increased susceptibility to endotoxin shock J:160543
increased susceptibility to induced morbidity/mortality J:160543
Tnfrsf1atm2.1Rsie/Tnfrsf1atm2.1Rsie
B6.Cg-Tnfrsf1atm2.1Rsie 		abnormal chemokine secretion J:160543
abnormal macrophage physiology J:160543
decreased circulating interleukin-6 level J:160543
decreased interleukin-6 secretion J:160543
decreased susceptibility to endotoxin shock J:160543
decreased susceptibility to induced morbidity/mortality J:160543
increased circulating tumor necrosis factor level J:160543
Tnfrsf1atm2b(EUCOMM)Wtsi/Tnfrsf1atm2b(EUCOMM)Wtsi
C57BL/6N-Tnfrsf1atm2b(EUCOMM)Wtsi/H 		decreased circulating calcium level J:211773
decreased monocyte cell number J:211773
decreased neutrophil cell number J:211773
increased basophil cell number J:211773
increased eosinophil cell number J:211773
increased grip strength J:211773
increased large unstained cell number J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
Tnfrsf1atm2Gkl/Tnfrsf1a+
Tg(Vil1-cre)997Gum/0
involves: 129S/SvEv * C57BL/6J * SJL 		abnormal intestine physiology J:210950
increased susceptibility to induced morbidity/mortality J:210950
Tnfrsf1atm3.1Gkl/Tnfrsf1a+
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL 		abnormal response/metabolism to endogenous compounds J:210950
decreased susceptibility to induced morbidity/mortality J:210950
Tnfrsf1atm3.1Gkl/Tnfrsf1atm3.1Gkl
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL 		abnormal response/metabolism to endogenous compounds J:210950
decreased susceptibility to induced morbidity/mortality J:210950
Tnfrsf1atm4.1(TNFRSF1A)Gkl/Tnfrsf1a+
involves: 129P2/OlaHsd 		decreased susceptibility to induced morbidity/mortality J:210950
tumor regression J:210950
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory