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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfrsf11a
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
MGI:1314891
67 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Vil1-cre)997Gum/0
Tnfrsf11atm1.1Irw/Tnfrsf11atm1.1Irw
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac * SJL 		abnormal Peyer's patch epithelium morphology J:219915, J:226603
abnormal Peyer's patch follicle morphology J:226603
abnormal Peyer's patch germinal center morphology J:226603
abnormal Peyer's patch morphology J:226603
abnormal Peyer's patch T cell area morphology J:226603
decreased IgA level J:226603
decreased plasma cell number J:226603
Tnfrsf11adel8/Tnfrsf11adel8
involves: 129 		abnormal hematopoietic system morphology/development J:111512
abnormal long bone hypertrophic chondrocyte zone J:111512
abnormal mesenteric lymph node morphology J:111512
abnormal trabecular bone morphology J:111512
anemia J:111512
decreased body size J:111512
decreased osteoclast cell number J:111512
enlarged liver J:111512
enlarged spleen J:111512
extramedullary hematopoiesis J:111512
failure of tooth eruption J:111512
increased bone mineral density J:111512
increased long bone epiphyseal plate size J:111512
kyphosis J:111512
osteopetrosis J:111512
premature death J:111512
short snout J:111512
Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Gfap-cre)2Brn/0
involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N 		abnormal body temperature homeostasis J:155398
abnormal circadian temperature homeostasis J:155398
abnormal response/metabolism to endogenous compounds J:155398
decreased prostaglandin level J:155398
decreased susceptibility to endotoxin shock J:155398
impaired febrile response J:155398
Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * C57BL/6NTac * SJL 		abnormal body temperature homeostasis J:155398
abnormal circadian temperature homeostasis J:155398
abnormal response/metabolism to endogenous compounds J:155398
decreased prostaglandin level J:155398
decreased susceptibility to endotoxin shock J:155398
impaired febrile response J:155398
Tnfrsf11atm1.1Sral/Tnfrsf11a+
B6.129P2(Cg)-Tnfrsf11atm1.1Sral 		abnormal bone structure J:312215
abnormal osteoclast differentiation J:312215
abnormal osteoclast physiology J:312215
abnormal tibia morphology J:312215
decreased bone trabecular spacing J:312215
decreased tumor necrosis factor (ligand) superfamily member 11 level J:312215
normal growth/size/body region phenotype J:312215
increased bone trabecula number J:312215
increased osteoblast cell number J:312215
increased osteoclast cell number J:312215
increased trabecular bone thickness J:312215
increased trabecular bone volume J:312215
normal mortality/aging J:312215
Tnfrsf11atm1.1Sral/Tnfrsf11atm1.1Sral
B6.129P2(Cg)-Tnfrsf11atm1.1Sral 		abnormal bone structure J:312215
abnormal long bone metaphysis morphology J:312215
abnormal osteoclast differentiation J:312215
abnormal tibia morphology J:312215
abnormal trabecular bone morphology J:312215
absent incisors J:312215
decreased body size J:312215
decreased bone trabecular spacing J:312215
decreased compact bone thickness J:312215
decreased osteoclast cell number J:312215
increased bone trabecula number J:312215
increased long bone epiphyseal plate size J:312215
increased trabecular bone thickness J:312215
increased trabecular bone volume J:312215
osteopetrosis J:312215
osteosclerosis J:312215
premature death J:312215
Tnfrsf11atm1.2Pngr/Tnfrsf11atm1.2Pngr
B6.Cg-Tnfrsf11atm1.2Pngr 		absent lymph nodes J:155398
decreased osteoclast cell number J:155398
failure of tooth eruption J:155398
osteopetrosis J:155398
Tnfrsf11atm1Imx/Tnfrsf11atm1Imx
involves: 129 		abnormal negative T cell selection J:125864
abnormal thymus epithelium morphology J:125864
Tnfrsf11atm1Imx/Tnfrsf11atm1Imx
involves: 129 * C57BL/6 		abnormal common myeloid progenitor cell morphology J:57899
abnormal nasal mucosa morphology J:57899
abnormal osteoclast differentiation J:57899
absent lymph nodes J:57899
decreased B cell number J:57899
decreased body size J:57899
decreased bone marrow cell number J:57899
decreased compact bone thickness J:57899
decreased mature B cell number J:57899
decreased osteoclast cell number J:57899
decreased Peyer's patch number J:57899
decreased spleen germinal center size J:57899
domed cranium J:57899
extramedullary hematopoiesis J:57899
failure of tooth eruption J:57899
increased bone mineral density J:57899
increased diameter of long bones J:57899
increased granulocyte number J:57899
increased neutrophil cell number J:57899
osteopetrosis J:57899
short limbs J:57899
small Peyer's patches J:57899
spleen hyperplasia J:57899
tooth impaction J:57899
Tnfrsf11atm1Wjb/Tnfrsf11atm1Wjb
involves: 129X1/SvJ * C57BL/6 		abnormal mammary gland growth during pregnancy J:64718
failure of tooth eruption J:64718
lactation failure J:64718
osteopetrosis J:64718
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory