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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
MGI:1315204
71 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Meox2tm1(cre)Sor/Meox2+
Slc40a1tm2Nca/Slc40a1tm2Nca
involves: 129S4/SvJae * 129S6/SvEvTac 		abnormal erythrocyte morphology J:129846
abnormal liver iron level J:129846
anemia J:129846
anisocytosis J:129846
decreased body size J:129846
decreased hemoglobin content J:129846
decreased mean corpuscular hemoglobin J:129846
decreased mean corpuscular volume J:129846
increased intestinal iron level J:129846
increased spleen iron level J:129846
normal mortality/aging J:129846
pallor J:129846
poikilocytosis J:129846
reticulocytosis J:129846
Slc40a1ffe/Slc40a1+
either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J) 		abnormal erythrocyte morphology J:118592
abnormal macrophage physiology J:118592
anemia J:118592
anisocytosis J:118592
decreased mean corpuscular hemoglobin J:118592
increased circulating ferritin level J:118592
increased circulating unsaturated transferrin level J:118592
increased liver iron level J:118592
leptocytosis J:118592
Slc40a1ffe/Slc40a1ffe
involves: 129X1/SvJ * C57BL/6J 		anemia J:118592
normal homeostasis/metabolism phenotype J:118592
normal nervous system phenotype J:118592
prenatal lethality, complete penetrance J:118592
normal vision/eye phenotype J:118592
Slc40a1ffe/Slc40a1ffe
involves: C3H/HeJ * C57BL/6J 		abnormal forebrain development J:118592
abnormal neural tube closure J:118592
anemia J:118592
edema J:118592
microphthalmia J:118592
prenatal lethality, complete penetrance J:118592
Slc40a1Pcm/Slc40a1+
A.Cg-Slc40a1Pcm 		abnormal spleen development J:98335
abnormal spleen physiology J:98335
decreased liver iron level J:98335
decreased spleen iron level J:98335
increased splenocyte apoptosis J:98335
polycythemia J:89185
small spleen J:98335
Slc40a1Pcm/Slc40a1+
involves: 101/H * C3H/HeH 		polycythemia J:30568
Slc40a1Pcm/Slc40a1Pcm
A.Cg-Slc40a1Pcm 		abnormal spleen development J:98335
decreased circulating iron level J:89185
decreased liver iron level J:98335
decreased spleen iron level J:98335
hypochromic microcytic anemia J:89185
increased liver iron level J:89185
increased splenocyte apoptosis J:98335
pallor J:98335
small spleen J:98335
Slc40a1tm1.1Mmfe/Slc40a1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal enzyme/coenzyme level J:215585
abnormal iron homeostasis J:215585
decreased circulating unsaturated transferrin level J:215585
decreased spleen iron level J:215585
increased circulating ferritin level J:215585
increased circulating iron level J:215585
increased circulating lipase level J:215585
increased liver iron level J:215585
increased pancreas iron level J:215585
oxidative stress J:215585
Slc40a1tm1.1Mmfe/Slc40a1tm1.1Mmfe
involves: 129P2/OlaHsd * C57BL/6 		abnormal enzyme/coenzyme level J:215585
abnormal iron homeostasis J:215585
abnormal liver morphology J:215585
abnormal liver physiology J:215585
abnormal pancreas morphology J:215585
abnormal pancreatic acinar cell morphology J:215585
cachexia J:215585
decreased circulating unsaturated transferrin level J:215585
decreased intestinal iron level J:215585
decreased spleen iron level J:215585
hemochromatosis J:215585
increased brain iron level J:215585
increased circulating ferritin level J:215585
increased circulating iron level J:215585
increased circulating lipase level J:215585
increased erythrocyte cell number J:215585
increased heart iron level J:215585
increased hematocrit J:215585
increased hemoglobin content J:215585
increased kidney iron level J:215585
increased liver iron level J:215585
increased mean corpuscular volume J:215585
increased pancreas iron level J:215585
oxidative stress J:215585
premature death J:215585
Slc40a1tm1b(EUCOMM)Hmgu/Slc40a1+
C57BL/6N-Slc40a1tm1b(EUCOMM)Hmgu/H 		decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased lean body mass J:211773
increased circulating triglyceride level J:211773
increased total body fat amount J:211773
Slc40a1tm1b(EUCOMM)Hmgu/Slc40a1tm1b(EUCOMM)Hmgu
C57BL/6N-Slc40a1tm1b(EUCOMM)Hmgu/H 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Slc40a1tm1Dgen/Slc40a1+
involves: 129P2/OlaHsd * C57BL/6 		decreased thermal nociceptive threshold J:101679
Slc40a1tm1Dgen/Slc40a1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality between somite formation and embryo turning, complete penetrance J:101679
Slc40a1tm1Nca/Slc40a1+
involves: 129S4/SvJae * 129S6/SvEvTac 		decreased hemoglobin content J:129846
decreased liver iron level J:129846
decreased mean corpuscular volume J:129846
normal hematopoietic system phenotype J:129846
increased spleen iron level J:129846
Slc40a1tm1Nca/Slc40a1tm1Nca
involves: 129S4/SvJae * 129S6/SvEvTac 		decreased embryo size J:129846
embryonic lethality between implantation and somite formation, incomplete penetrance J:129846
Slc40a1tm2Nca/Slc40a1tm2Nca
Tg(Vil1-cre)20Syr/0
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2 		prenatal lethality, complete penetrance J:129846
Slc40a1tm2Nca/Slc40a1tm2Nca
Tg(Vil1-cre/ERT2)23Syr/0
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2 		anemia J:129846
decreased hematocrit J:129846
decreased hemoglobin content J:129846
decreased liver iron level J:129846
decreased spleen iron level J:129846
increased intestinal iron level J:129846
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/05/2024
MGI 6.24 		The Jackson Laboratory