Slit2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slit2
slit guidance ligand 2
MGI:1315205

29 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slit2^b2b1200.1Clo/Slit2^b2b1200.1Clo C57BL/6J-Slit2^b2b1200.1Clo	aortic arch hypoplasia	J:175213
	double outlet right ventricle	J:175213
	duplex kidney	J:175213
	heart right ventricle hypoplasia	J:175213
	heterotaxia	J:175213
	hydronephrosis	J:175213
	muscular ventricular septal defect	J:175213
	perimembraneous ventricular septal defect	J:175213
	polycystic kidney	J:175213
	vascular ring	J:175213
Slit2^em1(IMPC)Mbp/Slit2⁺ C57BL/6N-Slit2^em1(IMPC)Mbp/MbpMmucd	abnormal kidney morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal placenta vasculature	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	enlarged kidney	J:211773
	hydrometra	J:211773
	microphthalmia	J:211773
Slit2^em1(IMPC)Mbp/Slit2^em1(IMPC)Mbp C57BL/6N-Slit2^em1(IMPC)Mbp/MbpMmucd	abnormal placenta morphology	J:211773
	preweaning lethality, complete penetrance	J:211773
Slit2^tm1.1Ics/Slit2^tm1.1Ics involves: 129S2/SvPas * C57BL/6 * CD-1	abnormal Purkinje cell dendrite morphology	J:221288
Slit2^tm1.1Ics/Slit2^tm1.1Ics Tg(Pcp2-cre)2Mpin/? involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1	abnormal Purkinje cell dendrite morphology	J:221288
Slit2^tm1Matl/Slit2^tm1Matl involves: 129S2/SvPas	abnormal cell adhesion	J:106011
	abnormal foregut morphology	J:193400
	abnormal kidney development	J:90324
	abnormal mammary gland duct morphology	J:106011
	abnormal nephrogenic zone morphology	J:90324
	abnormal ureter morphology	J:90324
	abnormal ureteric bud morphology	J:90324
	hydroureter	J:90324
	perinatal lethality, incomplete penetrance	J:90324

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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