Sphk1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sphk1
sphingosine kinase 1
MGI:1316649

16 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sphk1^em1(IMPC)Mbp/Sphk1^em1(IMPC)Mbp C57BL/6N-Sphk1^em1(IMPC)Mbp/MbpMmucd	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
	small kidney	J:211773
Sphk1^tm1.1Cgh/Sphk1^tm1.1Cgh involves: 129S4/SvJae * C57BL/6	abnormal myocardial fiber physiology	J:119827
Sphk1^tm1Npa/Sphk1^tm1Npa BALB/c-Sphk1^tm1Npa	increased B cell number	J:129314
Sphk1^tm1Rlp/Sphk1^tm1Rlp involves: 129S6/SvEvTac	abnormal cytokine level	J:133917
	decreased susceptibility to endotoxin shock	J:133917
	decreased susceptibility to induced morbidity/mortality	J:133917
	enlarged mesenteric lymph nodes	J:133917
Sphk1^tm1Rlp/Sphk1^tm1Rlp involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:95168

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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