Sphk1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sphk1
sphingosine kinase 1
MGI:1316649

35 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Lyve1^{tm1.1(EGFP/cre)Cys}/Lyve1⁺ Sphk1^tm2Cgh/Sphk1^tm2Cgh Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal leukocyte migration	J:156826
	abnormal lymph node morphology	J:156826
	abnormal lymphatic vessel morphology	J:156826
	abnormal lymphocyte cell number	J:156826
	abnormal Peyer's patch T cell area morphology	J:156826
	decreased B cell number	J:156826
	decreased splenocyte number	J:156826
	decreased T cell number	J:156826
	normal immune system phenotype	J:156826
Sphk1^tm1.1Cgh/Sphk1^tm2Cgh Sphk2^tm1.1Cgh/Sphk2^tm1.1Cgh Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA	abnormal immune serum protein physiology	J:120783
	abnormal NK cell differentiation	J:154069
	abnormal T cell differentiation	J:120783
	abnormal thymus cell ratio	J:120783
	decreased B cell number	J:120783
	decreased bone marrow cell number	J:120783
	decreased NK cell number	J:154069
	decreased T cell number	J:120783
	hemorrhage	J:205423
	increased NK cell number	J:154069
	increased vascular permeability	J:205423
Sphk1^tm1Rlp/Sphk1^tm1Rlp Sphk2^tm1Rlp/Sphk2^tm1Rlp involves: 129S6/SvEvTac * C57BL/6	abnormal blood vessel morphology	J:103755
	abnormal dorsal aorta morphology	J:103755
	abnormal embryonic neuroepithelium morphology	J:103755
	abnormal vascular endothelial cell morphology	J:103755
	abnormal vascular smooth muscle morphology	J:103755
	decreased embryonic neuroepithelium thickness	J:103755
	dilated brain ventricle	J:103755
	embryonic lethality during organogenesis, complete penetrance	J:103755
	exencephaly	J:103755
	hemopericardium	J:103755
	hemorrhage	J:103755
	incomplete rostral neuropore closure	J:103755
	increased embryonic neuroepithelium apoptosis	J:103755
	increased hindbrain apoptosis	J:103755
	increased midbrain apoptosis	J:103755
	intracranial hemorrhage	J:103755
	intraventricular hemorrhage	J:103755
	spinal hemorrhage	J:103755

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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