Men1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Men1
multiple endocrine neoplasia 1
MGI:1316736

26 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn1b^tm1Ako/Cdkn1b^tm1Ako Men1^tm1.1Ctre/Men1⁺ involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	increased adrenal gland tumor incidence	J:120835
	increased lung adenoma incidence	J:120835
	increased pancreas tumor incidence	J:120835
	increased parathyroid gland tumor incidence	J:120835
	increased pituitary gland tumor incidence	J:120835
	increased testis tumor incidence	J:120835
	increased thyroid tumor incidence	J:120835
	increased tumor incidence	J:120835
Cdkn1b^tm1Ako/Cdkn1b^tm1Ako Men1^tm1.1Ctre/Men1^tm1.1Ctre involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	embryonic lethality, complete penetrance	J:120835
Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Men1^tm1.1Ctre/Men1⁺ involves: 129/Sv * 129S6/SvEvTac * C57BL/6	decreased tumor latency	J:120835
	increased adenocarcinoma incidence	J:120835
	increased adrenal gland tumor incidence	J:120835
	increased Leydig cell tumor incidence	J:120835
	increased lung adenocarcinoma incidence	J:120835
	increased lung adenoma incidence	J:120835
	increased lung tumor incidence	J:120835
	increased pancreas tumor incidence	J:120835
	increased parathyroid gland tumor incidence	J:120835
	increased testis tumor incidence	J:120835
	increased thyroid tumor incidence	J:120835
Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Men1^tm1.1Ctre/Men1^tm1.1Ctre involves: 129/Sv * 129S6/SvEvTac * C57BL/6	embryonic lethality, complete penetrance	J:120835
Kdm5a^tm1Kael/Kdm5a^tm1Kael Men1^tm2.1Mmey/Men1^tm2.1Mmey Tg(Ins2-cre)23Herr/0 involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N	abnormal pancreatic islet morphology	J:175625
	normal endocrine/exocrine gland phenotype	J:175625
	increased insulinoma incidence	J:175625
	pancreatic islet hyperplasia	J:175625
	premature death	J:175625
Men1^tm1.1Ctre/Men1⁺ Rb1^tm1Tyj/Rb1⁺ involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N	increased adrenal gland tumor incidence	J:133299
	increased metastatic potential	J:133299
	increased pancreas tumor incidence	J:133299
	increased parathyroid gland tumor incidence	J:133299
	increased pheochromocytoma incidence	J:133299
	increased pituitary adenohypophysis tumor incidence	J:133299
	increased pituitary melanotroph tumor incidence	J:133299
	increased thyroid C-cell carcinoma incidence	J:133299
	premature death	J:133299
Men1^tm1.2Ctre/Men1^tm1.2Ctre Pax3^tm1(cre)Joe/Pax3⁺ Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac	normal cardiovascular system phenotype	J:127545
	normal digestive/alimentary phenotype	J:127545

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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