Lcp2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lcp2
lymphocyte cytosolic protein 2
MGI:1321402

39 phenotypes from 8 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lcp2^m1Khoe/Lcp2^m1Khoe C57BL/6J-Lcp2^m1Khoe	abnormal NK cell physiology	J:196519
Lcp2^m1Khoe/Lcp2^m1Khoe C57BL/6J-Lcp2^m1Khoe	impaired natural killer cell mediated cytotoxicity	J:196519
Lcp2^tm1.1Wz/Lcp2^tm1.1Wz B6.Cg-Lcp2^tm1.1Wz	abnormal effector T cell morphology	J:150304
	abnormal T cell differentiation	J:150304
	abnormal T cell subpopulation ratio	J:150304
	decreased CD4-positive, alpha-beta T cell number	J:150304
	decreased CD8-positive, alpha-beta T cell number	J:150304
	decreased double-negative T cell number	J:150304
	decreased interleukin-2 secretion	J:150304
	decreased T cell number	J:150304
	decreased T cell proliferation	J:150304
	decreased thymocyte number	J:150304
	normal immune system phenotype	J:150304
	increased double-negative T cell number	J:150304
	lymph node hypoplasia	J:150304
	small thymus	J:150304
Lcp2^{tm1b(KOMP)Wtsi}/Lcp2⁺ C57BL/6N-Lcp2^{tm1b(KOMP)Wtsi}/Orl	abnormal lens morphology	J:211773
	cataract	J:211773
Lcp2^{tm1b(KOMP)Wtsi}/Lcp2^{tm1b(KOMP)Wtsi} C57BL/6N-Lcp2^{tm1b(KOMP)Wtsi}/Orl	preweaning lethality, complete penetrance	J:211773
Lcp2^tm1Gak/Lcp2^tm1Gak involves: 129S1/Sv * 129X1/SvJ	abnormal platelet activation	J:162815
	decreased platelet aggregation	J:162815
	perinatal lethality, incomplete penetrance	J:91369
Lcp2^tm1Geha/Lcp2^tm1Geha involves: 129S4/SvJae	decreased interferon-gamma secretion	J:131621
	impaired natural killer cell mediated cytotoxicity	J:131621
	increased NK cell number	J:131621
Lcp2^tm2Gak/Lcp2^tm2Gak Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:107467
	decreased T cell apoptosis	J:107467
	increased CD8-positive, alpha-beta T cell number	J:107467
	increased gamma-delta T cell number	J:107467
	thymus hypoplasia	J:107467
Lcp2^tm4Gak/Lcp2^tm4Gak involves: 129S6/SvEvTac * BALB/c * C57BL/6	abnormal negative T cell selection	J:132995
Lcp2^tm4Gak/Lcp2^tm4Gak involves: 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal double-negative T cell morphology	J:132995
	abnormal negative T cell selection	J:132995
	abnormal T cell activation	J:132995
	abnormal T cell subpopulation ratio	J:132995
	decreased NK T cell number	J:132995
Lcp2^twm/Lcp2^twm C57BL/6JSfdAnu-Lcp2^twm/Anu	abnormal double-positive T cell morphology	J:104190
	abnormal negative T cell selection	J:104190
	abnormal positive T cell selection	J:104190
	abnormal T cell physiology	J:104190
	arrested T cell differentiation	J:104190
	autoimmune response	J:104190
	decreased T cell number	J:104190
	decreased thymocyte number	J:104190
	increased IgE level	J:104190
	increased IgG level	J:104190

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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