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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptf1a
pancreas specific transcription factor, 1a
MGI:1328312
26 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
involves: 129S1/Sv * 129X1/SvJ 		abnormal eye development J:115271
abnormal retina morphology J:115271
abnormal retina outer plexiform layer morphology J:200752
absent amacrine cells J:115271
absent pancreas J:130251
absent retina horizontal cells J:115271
absent retina inner plexiform layer J:115271
increased retina ganglion cell number J:115271
neonatal lethality, complete penetrance J:130251
thick retina ganglion layer J:115271
Ptf1atm1Pkwe/Ptf1atm1Pkwe
involves: 129P2/OlaHsd 		abnormal cerebellum development J:120017
absent cerebellum J:120017
absent pancreas J:120017
Ptf1atm1Pkwe/Ptf1atm1Pkwe
involves: 129P2/OlaHsd * C57BL/6 		abnormal spleen morphology J:51571
absent pancreas J:51571
cyanosis J:51571
decreased body weight J:51571
decreased pancreatic alpha cell number J:51571
hypoglycemia J:51571
neonatal lethality, complete penetrance J:51571
Ptf1atm2.1Mgn/Ptf1atm2.1Mgn
Not Specified 		increased retina ganglion cell number J:115271
Ptf1atm2Macd/Ptf1atm2Macd
involves: 129S1/Sv * 129X1/SvJ 		abnormal cerebellar granule layer morphology J:130251
abnormal glutaminergic neuron morphology J:130251
abnormal neural tube morphology J:130251
abnormal neuron differentiation J:130251
abnormal pancreas development J:125691
abnormal spinal cord dorsal horn morphology J:130251
absent pancreas J:130251
decreased neuronal precursor cell number J:130251
loss of GABAergic neurons J:130251
neonatal lethality, complete penetrance J:130251
small cerebellum J:130251
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory