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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptf1a
pancreas specific transcription factor, 1a
MGI:1328312
106 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cadpstm1.1Tfr/Cadpstm1.2Tfr
Ptf1atm1.1(cre)Cvw/Ptf1a+
B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr 		abnormal cerebellar molecular layer J:204664
abnormal paired-pulse inhibition J:204664
abnormal synaptic bouton morphology J:204664
abnormal synaptic vesicle number J:204664
decreased excitatory postsynaptic current amplitude J:204664
normal nervous system phenotype J:204664
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
increased tumor incidence J:116130
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		normal nervous system phenotype J:243947
Diras2em1Gpt/Diras2em1Gpt
Krastm4Tyj/Kras+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae * C57BL/6J * C57BL/6JGpt 		increased pancreatic ductal adenocarcinoma incidence J:348744
Diras2em1Gpt/Diras2em1Gpt
Krastm4Tyj/Kras+
Ptf1atm1(cre)Hnak/Ptf1a+
Ube2ftm1c(EUCOMM)Hmgu/Ube2ftm1c(EUCOMM)Hmgu
involves: 129S4/SvJae * C57BL/6 		increased pancreas tumor incidence J:348744
Etn2Sd/Etn2+
Ptf1a/Ptf1aostm1Kymm/Ptf1a+
involves: C57BL/6 		abnormal skeleton morphology J:195133
abnormal tail morphology J:195133
absent pancreas J:195133
Etn2Sd/Etn2+
Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a+
involves: C57BL/6 		short tail J:195133
short vertebral column J:195133
Etn2Sd/Etn2+
Ptf1a/Ptf1aostm3(CAG-Ptf1aos)Kymm/Ptf1a+
involves: C57BL/6 		no abnormal phenotype detected J:195133
Etn2Sd/Etn2Sd
Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a/Ptf1aostm2(Ptf1a)Kymm
involves: C57BL/6 		abnormal anus morphology J:195133
abnormal nucleus pulposus morphology J:195133
absent tail J:195133
decreased body length J:195133
normal endocrine/exocrine gland phenotype J:195133
short vertebral column J:195133
Etn2Sd/Etn2Sd
Ptf1a/Ptf1aostm3(CAG-Ptf1aos)Kymm/Ptf1a/Ptf1aostm3(CAG-Ptf1aos)Kymm
involves: C57BL/6 		no abnormal phenotype detected J:195133
Fat3tm1.1Good/Fat3tm1.2Good
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal retina neuronal layer morphology J:176668
Fat3tm1.2Good/Fat3tm1.2Good
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(CAG-Bgeo/GFP)21Lbe/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal amacrine cell morphology J:176668
abnormal retina neuronal layer morphology J:176668
Gad1tm2Oba/Gad1tm2Oba
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ 		abnormal gait J:134497
abnormal inhibitory postsynaptic currents J:134497
abnormal nervous system morphology J:134497
normal craniofacial phenotype J:134497
normal endocrine/exocrine gland phenotype J:134497
normal homeostasis/metabolism phenotype J:134497
impaired coordination J:134497
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras2)12Hev/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased pancreas tumor incidence J:184378
increased pancreatic intraepithelial neoplasia incidence J:184378
increased susceptibility to injury J:184378
pancreatic acinar-to-ductal metaplasia J:184378
small pancreas J:184378
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras2)12Hev/0
Trp53tm1Tyj/Trp53+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		increased pancreatic ductal adenocarcinoma incidence J:184378
increased pancreatic intraepithelial neoplasia incidence J:184378
increased susceptibility to injury J:184378
premature death J:184378
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras*G12D)#Rdp/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		increased pancreatic ductal adenocarcinoma incidence J:186194
increased pancreatic intraepithelial neoplasia incidence J:186194
pancreatic acinar-to-ductal metaplasia J:186194
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras*G12D)#Rdp/0
Trp53tm1Brn/Trp53+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		increased pancreatic ductal adenocarcinoma incidence J:186194
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras*G12D)#Rdp/0
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		increased pancreatic ductal adenocarcinoma incidence J:186194
Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J 		increased pancreatic ductal adenocarcinoma incidence J:140423
premature death J:140423
Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S6/SvEvTac * C57BL/6J 		increased incidence of induced tumors J:140423
increased pancreatic ductal adenocarcinoma incidence J:140423
increased pancreatic intraepithelial neoplasia incidence J:140423
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ptf1atm1(cre)Cvw/Ptf1atm2Macd
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal pancreas development J:125691
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss 		abnormal digestive system development J:78710
abnormal pancreas development J:78710
absent pancreatic acini J:78710
increased retina ganglion cell number J:115271
Gt(ROSA)26Sortm1Sor/?
Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
involves: 129S4/SvJaeSor 		abnormal retina layer morphology J:119184
abnormal retina neuronal layer morphology J:119184
absent amacrine cells J:119184
absent retina inner plexiform layer J:119184
neonatal lethality, complete penetrance J:119184
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae * 129S6/SvEvTac 		normal endocrine/exocrine gland phenotype J:197054
normal neoplasm J:197054
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S6/SvEvTac 		normal endocrine/exocrine gland phenotype J:197054
normal neoplasm J:197054
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S6/SvEvTac 		enlarged pancreas J:197054
increased carcinoma incidence J:197054
increased pancreas weight J:197054
increased pancreatic ductal adenocarcinoma incidence J:197054
increased pancreatic intraepithelial neoplasia incidence J:197054
pancreatic acinar-to-ductal metaplasia J:197054
Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+
involves: C57BL/6 		normal endocrine/exocrine gland phenotype J:197054
normal neoplasm J:197054
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm2Tyj
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129P2/OlaHsd * 129S4/SvJae 		increased pancreatic ductal adenocarcinoma incidence J:197054
Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2 		increased metastatic potential J:116129
increased pancreas tumor incidence J:116129
increased pancreatic ductal adenocarcinoma incidence J:116129
increased pancreatic intraepithelial neoplasia incidence J:116129
premature death J:116129
Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal duodenum morphology J:116129
abnormal hepatic portal vein morphology J:116129
abnormal hepatic portal vein thrombosis J:116129
dilated gallbladder J:116129
distended abdomen J:116129
enlarged spleen J:116129
hemorrhagic ascites J:116129
hepatic necrosis J:116129
increased metastatic potential J:116129
increased pancreas tumor incidence J:116129
increased pancreatic ductal adenocarcinoma incidence J:116129
increased pancreatic intraepithelial neoplasia incidence J:116129
jaundice J:116129
paralysis J:116129
premature death J:116129
weight loss J:116129
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
B6.129(Cg)-Krastm4Tyj Ptf1atm1.1(cre)Cvw 		increased metastatic potential J:138959
increased pancreas tumor incidence J:138959
increased pancreas weight J:138959
increased pancreatic ductal adenocarcinoma incidence J:138959
increased pancreatic intraepithelial neoplasia incidence J:138959
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		abnormal pancreatic acinar cell morphology J:262746
enlarged pancreas J:87973
increased pancreatic ductal adenocarcinoma incidence J:87973, J:116130
increased pancreatic intraepithelial neoplasia incidence J:262746
increased tumor incidence J:87973
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		increased pancreatic intraepithelial neoplasia incidence J:116129
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MUC1)79.24Gend/0
B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw Tg(MUC1)79.24Gend 		decreased metastatic potential J:138959
increased pancreas tumor incidence J:138959, J:234412
increased pancreatic ductal adenocarcinoma incidence J:138959
increased pancreatic intraepithelial neoplasia incidence J:138959, J:234412
Krastm4Tyj/Kras+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae 		abnormal pancreas morphology J:197054
normal neoplasm J:197054
Krastm4Tyj/Kras+
Raf1tm2Bacc/Raf1tm2Bacc
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129P2/OlaHsd * 129S4/SvJae 		increased pancreatic ductal adenocarcinoma incidence J:197054
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
increased tumor incidence J:116130
pancreas cyst J:116130
Krastm4Tyj/Kras+
Ptf1atm1(cre)Hnak/Ptf1a+
Ube2ftm1c(EUCOMM)Hmgu/Ube2ftm1c(EUCOMM)Hmgu
involves: 129S4/SvJae * C57BL/6J * C57BL/6N 		decreased susceptibility to induced pancreatitis J:348744
decreased tumor incidence J:348744
increased body weight J:348744
small pancreas J:348744
Krastm4Tyj/Kras+
Tg(Erbb2*)#Maed/0
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J 		abnormal pancreatic acinar cell morphology J:262746
increased pancreatic intraepithelial neoplasia incidence J:262746
Krastm4Tyj/Krastm4Tyj
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae 		increased pancreatic intraepithelial neoplasia incidence J:162125
Notch1tm1Agt/Notch1tm1Agt
Notch2tm1Frad/Notch2tm1Frad
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129 * BALB/cJ 		abnormal branching involved in pancreas development J:139250
abnormal endocrine pancreas morphology J:139250
abnormal pancreas development J:139250
abnormal pancreatic acinus morphology J:139250
abnormal pancreatic bud formation J:139250
decreased pancreatic islet number J:139250
small pancreas J:139250
Pgbd5tm1.1Aken/Pgbd5tm1.2Aken
Ptch1tm1Bjw/Ptch1tm1Bjw
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW 		increased medulloblastoma incidence J:346387
Pgbd5tm1.2Aken/Pgbd5tm1.2Aken
Ptch1tm1Bjw/Ptch1tm1Bjw
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW 		decreased classified tumor incidence J:346387
increased tumor-free survival time J:346387
Ptf1atm1(cre)Hnak/Ptf1a+
Rbpjtm1Rsch/Rbpjtm1Rsch
involves: 129X1/SvJ 		abnormal digestion J:139250
abnormal pancreas development J:139250
abnormal pancreas morphology J:139250
abnormal pancreatic alpha cell differentiation J:139250
decreased pancreatic acinar cell number J:139250
decreased pancreatic islet number J:139250
disorganized pancreatic islets J:139250
increased pancreatic alpha cell number J:139250
postnatal growth retardation J:139250
postnatal lethality, complete penetrance J:139250
small pancreas J:139250
Ptf1atm1(cre)Hnak/Ptf1a+
Ube2ftm1c(EUCOMM)Hmgu/Ube2ftm1c(EUCOMM)Hmgu
involves: C57BL/6J * C57BL/6N 		normal endocrine/exocrine gland phenotype J:348744
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal pancreas development J:116129
Ptf1atm1.1(cre)Cvw/Ptf1a+
Smad4tm1Rdp/Smad4tm1Rdp
involves: 129 * FVB/N 		normal endocrine/exocrine gland phenotype J:116130
Ptf1atm1.1(cre)Cvw/Ptf1a+
Robo3tm1.1Ache/Robo3tm1.1Ache
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		abnormal brain commissure morphology J:158918
abnormal innervation J:158918
abnormal motor coordination/balance J:158918
ataxia J:158918
impaired coordination J:158918
Ptf1atm1.1(cre)Cvw/Ptf1a+
Sec24ctm1c(EUCOMM)Wtsi/Sec24ctm1c(EUCOMM)Wtsi
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL 		normal endocrine/exocrine gland phenotype J:232065
normal growth/size/body region phenotype J:232065
normal homeostasis/metabolism phenotype J:232065
Ptf1atm1.1(cre)Cvw/CbllTg(Alb-KL)7-2Mhos
involves: C57BL/6 		abnormal GABAergic neuron morphology J:100997
abnormal Purkinje cell differentiation J:100997
Rbpjtm1Hon/Rbpjtm1.1Hon
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Ptf1atm2(cre/ESR1)Cvw/Ptf1a+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		normal endocrine/exocrine gland phenotype J:180310
Relatm1Rsch/Relatm1Rsch
Ptf1atm1(cre)Hnak/?
involves: C57BL/6 		abnormal interleukin level J:122194
abnormal response/metabolism to endogenous compounds J:122194
abnormal tumor necrosis factor level J:122194
increased susceptibility to xenobiotic induced morbidity/mortality J:122194
lung inflammation J:122194
pancreas inflammation J:122194
Sbdstm1Jrom/Sbdstm3.1Jrom
Ptf1atm1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ 		abnormal pancreatic islet size J:189357
decreased body length J:189357
decreased circulating amylase level J:189357
impaired glucose tolerance J:189357
pancreas hypoplasia J:189357
postnatal growth retardation J:189357
small pancreas J:189357
Sbdstm2.1Jrom/Sbdstm3.1Jrom
Ptf1atm1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ 		abnormal pancreatic islet size J:189357
decreased body length J:189357
decreased circulating amylase level J:189357
normal embryo phenotype J:189357
pancreas lipomatosis J:189357
pancreatic acinar hypoplasia J:189357
postnatal growth retardation J:189357
small pancreas J:189357
Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ 		normal endocrine/exocrine gland phenotype J:229184
Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal pancreas morphology J:229184
abnormal pancreatic acinar cell morphology J:229184
abnormal pancreatic duct morphology J:229184
abnormal pancreatic islet morphology J:229184
chronic pancreas inflammation J:229184
dilated pancreatic duct J:229184
enlarged pancreas J:229184
increased pancreatic intraepithelial neoplasia incidence J:229184
pancreas cyst J:229184
pancreas fibrosis J:229184
pancreatic acinar-to-ductal metaplasia J:229184
Tg(Erbb2*)#Maed/0
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S/Sv * 129X1/SvJ * C57BL/6J 		normal endocrine/exocrine gland phenotype J:262746
Tg(Etn2*,Ptf1aos,Ptf1a)#Kymm/0
involves: C57BL/6 		short tail J:195133
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11/19/2024
MGI 6.24 		The Jackson Laboratory