About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Trex1
three prime repair exonuclease 1
MGI:1328317
95 phenotypes from 4 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Trex1em1(IMPC)Ccpcz/Trex1+
C57BL/6NCrl-Trex1em1(IMPC)Ccpcz/Ccpcz 		abnormal bone structure J:211773
abnormal cranium morphology J:211773
abnormal epididymis morphology J:211773
abnormal heart morphology J:211773
abnormal kidney morphology J:211773
abnormal lens morphology J:211773
abnormal retina vasculature morphology J:211773
abnormal seminal vesicle morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
enlarged epididymis J:211773
enlarged heart J:211773
enlarged kidney J:211773
enlarged seminal vesicle J:211773
enlarged spleen J:211773
enlarged testis J:211773
Trex1em1(IMPC)Ccpcz/Trex1em1(IMPC)Ccpcz
C57BL/6NCrl-Trex1em1(IMPC)Ccpcz/Ccpcz 		abnormal heart morphology J:211773
abnormal liver morphology J:211773
abnormal skin morphology J:211773
abnormal spine curvature J:211773
abnormal spleen morphology J:211773
abnormal thymus morphology J:211773
abnormal tooth color J:211773
decreased lymphocyte cell number J:211773
decreased NK cell number J:211773
decreased total body fat amount J:211773
enlarged heart J:211773
enlarged liver J:211773
enlarged spleen J:211773
enlarged thymus J:211773
improved glucose tolerance J:211773
increased effector memory T-helper cell number J:211773
increased heart weight J:211773
increased kidney weight J:211773
increased lean body mass J:211773
increased mean platelet volume J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
kyphosis J:211773
scoliosis J:211773
short tibia J:211773
thrombocytopenia J:211773
Trex1em3Gpt/Trex1em3Gpt
C57BL/6JGpt-Trex1em3Gpt 		decreased body size J:330879
decreased body weight J:330879
enlarged spleen J:330879
increased circulating tumor necrosis factor level J:330879
increased spleen weight J:330879
increased susceptibility to autoimmune disorder J:330879
premature death J:330879
Trex1tm1.1Fwpe/Trex1+
involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac 		increased CD4-positive, alpha-beta T cell number J:220965
Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac 		abnormal atrial thrombosis J:220965
abnormal heart morphology J:220965
abnormal immune system organ morphology J:220965
abnormal kidney morphology J:220965
abnormal T cell activation J:220965
atelectasis J:220965
bronchiolitis J:220965
congestive heart failure J:220965
decreased litter size J:220965
dilated heart atrium J:220965
dilated heart ventricle J:220965
enlarged heart J:220965
enlarged lymph nodes J:220965
enlarged spleen J:220965
glomerulonephritis J:220965
heart inflammation J:220965
increased anti-double stranded DNA antibody level J:220965
increased B cell number J:220965
increased CD4-positive, alpha-beta T cell number J:220965
increased IgG level J:220965
increased inflammatory response J:220965
increased plasma cell number J:220965
increased regulatory T cell number J:220965
increased spleen weight J:220965
increased splenocyte number J:220965
increased susceptibility to systemic lupus erythematosus J:220965
lacrimal gland inflammation J:220965
liver vascular congestion J:220965
lymphoid hyperplasia J:220965
pancreas inflammation J:220965
premature death J:220965
renal glomerular immunoglobulin deposits J:220965
salivary gland inflammation J:220965
tubulointerstitial nephritis J:220965
vascular inflammation J:220965
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd 		abnormal atrial thrombosis J:92264
abnormal interferon secretion J:234263
abnormal myocardial fiber morphology J:92264
abnormal spleen marginal zone morphology J:92264
cardiomyopathy J:92264
enlarged lymph nodes J:92264
enlarged spleen J:92264
heart inflammation J:202757
hepatic necrosis J:92264
increased autoantibody level J:202757
increased spleen B cell follicle size J:92264
myocardial fiber degeneration J:92264
myocarditis J:92264
premature death J:92264, J:202757
renal necrosis J:92264
skin inflammation J:202757
thymus cortex hypoplasia J:92264
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N 		heart inflammation J:234263
increased autoantibody level J:234263
increased inflammatory response J:234263
kidney inflammation J:234263
myositis J:234263
premature death J:234263
stomach inflammation J:234263
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd * C57BL/6 		cardiac fibrosis J:181257
dermatitis J:181257
folliculitis J:181257
glomerulonephritis J:181257
normal immune system phenotype J:181257
increased anti-nuclear antigen antibody level J:181257
increased IgG level J:181257
increased inflammatory response J:181257
increased susceptibility to systemic lupus erythematosus J:181257
kidney inflammation J:181257
myocarditis J:181257
myositis J:181257
premature death J:181257
skin inflammation J:181257
stomach inflammation J:181257
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd * C57BL/6J 		dermatitis J:243357
increased susceptibility to autoimmune disorder J:243357
skin lesions J:243357
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory