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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Trex1
three prime repair exonuclease 1
MGI:1328317
95 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Trex1em1(IMPC)Ccpcz/Trex1+
C57BL/6NCrl-Trex1em1(IMPC)Ccpcz/Ccpcz 		abnormal bone structure J:211773
abnormal cranium morphology J:211773
abnormal epididymis morphology J:211773
abnormal heart morphology J:211773
abnormal kidney morphology J:211773
abnormal lens morphology J:211773
abnormal retina vasculature morphology J:211773
abnormal seminal vesicle morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
enlarged epididymis J:211773
enlarged heart J:211773
enlarged kidney J:211773
enlarged seminal vesicle J:211773
enlarged spleen J:211773
enlarged testis J:211773
Trex1em1(IMPC)Ccpcz/Trex1em1(IMPC)Ccpcz
C57BL/6NCrl-Trex1em1(IMPC)Ccpcz/Ccpcz 		abnormal heart morphology J:211773
abnormal liver morphology J:211773
abnormal skin morphology J:211773
abnormal spine curvature J:211773
abnormal spleen morphology J:211773
abnormal thymus morphology J:211773
abnormal tooth color J:211773
decreased lymphocyte cell number J:211773
decreased NK cell number J:211773
decreased total body fat amount J:211773
enlarged heart J:211773
enlarged liver J:211773
enlarged spleen J:211773
enlarged thymus J:211773
improved glucose tolerance J:211773
increased effector memory T-helper cell number J:211773
increased heart weight J:211773
increased kidney weight J:211773
increased lean body mass J:211773
increased mean platelet volume J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
kyphosis J:211773
scoliosis J:211773
short tibia J:211773
thrombocytopenia J:211773
Trex1em3Gpt/Trex1em3Gpt
C57BL/6JGpt-Trex1em3Gpt 		decreased body size J:330879
decreased body weight J:330879
enlarged spleen J:330879
increased circulating tumor necrosis factor level J:330879
increased spleen weight J:330879
increased susceptibility to autoimmune disorder J:330879
premature death J:330879
Trex1tm1.1Fwpe/Trex1+
involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac 		increased CD4-positive, alpha-beta T cell number J:220965
Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac 		abnormal atrial thrombosis J:220965
abnormal heart morphology J:220965
abnormal immune system organ morphology J:220965
abnormal kidney morphology J:220965
abnormal T cell activation J:220965
atelectasis J:220965
bronchiolitis J:220965
congestive heart failure J:220965
decreased litter size J:220965
dilated heart atrium J:220965
dilated heart ventricle J:220965
enlarged heart J:220965
enlarged lymph nodes J:220965
enlarged spleen J:220965
glomerulonephritis J:220965
heart inflammation J:220965
increased anti-double stranded DNA antibody level J:220965
increased B cell number J:220965
increased CD4-positive, alpha-beta T cell number J:220965
increased IgG level J:220965
increased inflammatory response J:220965
increased plasma cell number J:220965
increased regulatory T cell number J:220965
increased spleen weight J:220965
increased splenocyte number J:220965
increased susceptibility to systemic lupus erythematosus J:220965
lacrimal gland inflammation J:220965
liver vascular congestion J:220965
lymphoid hyperplasia J:220965
pancreas inflammation J:220965
premature death J:220965
renal glomerular immunoglobulin deposits J:220965
salivary gland inflammation J:220965
tubulointerstitial nephritis J:220965
vascular inflammation J:220965
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd 		abnormal atrial thrombosis J:92264
abnormal interferon secretion J:234263
abnormal myocardial fiber morphology J:92264
abnormal spleen marginal zone morphology J:92264
cardiomyopathy J:92264
enlarged lymph nodes J:92264
enlarged spleen J:92264
heart inflammation J:202757
hepatic necrosis J:92264
increased autoantibody level J:202757
increased spleen B cell follicle size J:92264
myocardial fiber degeneration J:92264
myocarditis J:92264
premature death J:92264, J:202757
renal necrosis J:92264
skin inflammation J:202757
thymus cortex hypoplasia J:92264
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N 		heart inflammation J:234263
increased autoantibody level J:234263
increased inflammatory response J:234263
kidney inflammation J:234263
myositis J:234263
premature death J:234263
stomach inflammation J:234263
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd * C57BL/6 		cardiac fibrosis J:181257
dermatitis J:181257
folliculitis J:181257
glomerulonephritis J:181257
normal immune system phenotype J:181257
increased anti-nuclear antigen antibody level J:181257
increased IgG level J:181257
increased inflammatory response J:181257
increased susceptibility to systemic lupus erythematosus J:181257
kidney inflammation J:181257
myocarditis J:181257
myositis J:181257
premature death J:181257
skin inflammation J:181257
stomach inflammation J:181257
Trex1tm1Tld/Trex1tm1Tld
involves: 129P2/OlaHsd * C57BL/6J 		dermatitis J:243357
increased susceptibility to autoimmune disorder J:243357
skin lesions J:243357
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory