Orc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Orc1
origin recognition complex, subunit 1
MGI:1328337

27 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Orc1^tm1.1Gle/Orc1^tm1.1Gle involves: C57BL/6 * SJL	absent fibroblast proliferation	J:272584
	decreased DNA replication	J:272584
	polyploidy	J:272584
Orc1^tm1.1Gle/Orc1^tm1.1Gle Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ involves: 129S2/SvPas * C57BL/6 * SJL	normal cellular phenotype	J:272584
	decreased hepatocyte number	J:272584
	increased hepatocyte karyomegaly	J:272584
	normal liver/biliary system phenotype	J:272584
	polyploidy	J:272584
Orc1^tm1.1Gle/Orc1^tm1.1Gle Prl2c2^tm1(cre)Gle/Prl2c2⁺ involves: C57BL/6 * SJL	no abnormal phenotype detected	J:272584
Orc1^tm1.1Gle/Orc1^tm1.1Gle Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * DBA * SJL	abnormal DNA replication	J:272584
	decreased hepatocyte number	J:272584
	increased hepatocyte karyomegaly	J:272584
	increased hepatocyte proliferation	J:272584
	normal liver/biliary system phenotype	J:272584
	polyploidy	J:272584
Orc1^tm1.1Gle/Orc1^tm1.1Gle Tg(Cyp1a1-cre)1Dwi/0 involves: C57BL/6 * CBA * SJL	abnormal small intestinal crypt cell proliferation	J:272584
	abnormal small intestinal villus morphology	J:272584
	abnormal small intestine crypts of Lieberkuhn morphology	J:272584
	abnormal small intestine morphology	J:272584
	decreased small intestinal villus height	J:272584
	increased DNA replication	J:272584
	increased small intestinal crypt cell apoptosis	J:272584
Orc1^tm1.1Gle/Orc1^tm1.2Gle Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: C57BL/6 * CBA * SJL	embryonic lethality, complete penetrance	J:272584
Orc1^tm1.1Gle/Orc1^tm1.2Gle Prl2c2^tm1(cre)Gle/Prl2c2⁺ involves: C57BL/6 * SJL	no abnormal phenotype detected	J:272584
Orc1^tm1.1Gle/Orc1^tm1.2Gle Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * DBA * SJL	abnormal DNA replication	J:272584
	decreased hepatocyte number	J:272584
	increased hepatocyte karyomegaly	J:272584
	polyploidy	J:272584
Orc1^tm1.2Gle/Orc1^tm1.2Gle involves: C57BL/6 * SJL	embryonic lethality at implantation, complete penetrance	J:272584
Orc1^{tm1a(KOMP)Wtsi}/Orc1⁺ C57BL/6N-Orc1^{tm1a(KOMP)Wtsi}/Wtsi	decreased total body fat amount	J:211773
	increased bone mineral content	J:211773
	increased bone mineral density	J:211773
	increased grip strength	J:211773
	increased lean body mass	J:211773
Orc1^{tm1a(KOMP)Wtsi}/Orc1^{tm1a(KOMP)Wtsi} C57BL/6N-Orc1^{tm1a(KOMP)Wtsi}/Wtsi	embryonic lethality prior to organogenesis	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Orc1^{tm1b(KOMP)Wtsi}/Orc1^{tm1b(KOMP)Wtsi} C57BL/6N-Orc1^{tm1b(KOMP)Wtsi}/J	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773

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