Sh2d1a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sh2d1a
SH2 domain containing 1A
MGI:1328352

14 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fas^lpr/Fas^lpr Sh2d1a^rpl/Sh2d1a^rpl MRL/Mp-Fas^lpr Sh2d1a^rpl	abnormal immune system physiology	J:126261
	increased anti-nuclear antigen antibody level	J:126261
Sh2d1a^tm1.1Knic/Y Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 involves: 129S/SvEv * 129X1/SvJ * C57BL/6	abnormal NK T cell physiology	J:196692
	decreased circulating interleukin-4 level	J:196692
	decreased interferon-gamma secretion	J:196692
	normal immune system phenotype	J:196692
Sh2d1a^tm1.1Knic/Sh2d1a^tm1.1Knic Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 involves: 129S/SvEv * 129X1/SvJ * C57BL/6	abnormal NK T cell physiology	J:196692
	decreased circulating interleukin-4 level	J:196692
	decreased interferon-gamma secretion	J:196692
	normal immune system phenotype	J:196692
Sh2d1a^tm1Cpt/Sh2d1a^tm1Cpt Sh2d1b1/Sh2d1b2^tm1.1Cpt/Sh2d1b1/Sh2d1b2^tm1.1Cpt involves: 129S4/SvJae * BALB/cJ	impaired natural killer cell mediated cytotoxicity	J:166054
Sh2d1a^tm1Cpt/Sh2d1a^tm1Cpt Sh2d1b1/Sh2d1b2^tm1.1Cpt/Sh2d1b1/Sh2d1b2^tm1.1Cpt involves: 129S4/SvJae * BALB/cJ	impaired natural killer cell mediated cytotoxicity	J:166054
Sh2d1a^tm1Cpt/Sh2d1a^tm1Cpt Tcra-J^tm1Tgi/Tcra-J^tm1Tgi involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c	decreased germinal center B cell number	J:189126
	decreased IgG level	J:189126
Sh2d1a^tm1Cpt/Y Tcra-J^tm1Tgi/Tcra-J^tm1Tgi involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c	decreased germinal center B cell number	J:189126
	decreased IgG level	J:189126
Sh2d1a^tm1Pls/Sh2d1a^tm1Pls Sh2d1b1^tm3Vei/Sh2d1b1^tm3Vei involves: 129S6/SvEvTac * C57BL/6	abnormal NK cell physiology	J:187430
Sh2d1a^tm1Pls/Sh2d1a^tm1Pls Slamf6^tm1Lex/Slamf6^tm1Lex B6.129S-Slamf6^tm1Lex Sh2d1a^tm1Pls	normal immune system phenotype	J:187429
Sh2d1a^tm1Pls/Sh2d1a^tm1Pls Slamf6^tm1Pls/Slamf6^tm1Pls Tg(TcraTcrb)1100Mjb/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J	normal immune system phenotype	J:187431
Sh2d1a^tm1Pls/Sh2d1a^tm1Pls Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo involves: BALB/c * C3H * C57BL/6	abnormal cytokine secretion	J:90484
Sh2d1a^tm1Pls/Sh2d1a^tm1Pls Tg(TcraTcrb)425Cbn/? involves: 129S6/SvEvTac * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:157915
Sh2d1a^tm1Pls/Sh2d1a^tm1Pls Tg(TcraTcrb)1100Mjb/0 involves: 129S6/SvEvTac * C57BL/6	abnormal cytotoxic T cell physiology	J:187431
	decreased cytotoxic T cell cytolysis	J:187431
	decreased interferon-gamma secretion	J:187431
Sh2d1a^tm1Vei/Sh2d1a^tm1Vei Sh2d1b1^tm3Vei/Sh2d1b1^tm3Vei involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal NK cell physiology	J:187430

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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