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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Wfs1
wolframin ER transmembrane glycoprotein
MGI:1328355
79 phenotypes from 4 alleles in 8 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Wfs1tm1.1Bedel/Wfs1tm1.1Bedel
involves: C57BL/6N
abnormal inner ear vestibule morphology J:342760
abnormal postural reflex J:342760
absent distortion product otoacoustic emissions J:342760
absent outer hair cell stereocilia J:342760
circling J:342760
deafness J:342760
decreased endocochlear potential J:342760
fused inner hair cell stereocilia J:342760
fused vestibular hair cell stereocilia J:342760
head bobbing J:342760
impaired coordination J:342760
impaired righting response J:342760
impaired swimming J:342760
increased or absent threshold for auditory brainstem response J:342760
normal nervous system phenotype J:342760
stria vascularis degeneration J:342760
vestibular hair cell degeneration J:342760
Wfs1tm1Koks/Wfs1+
129S6/SvEvTac-Wfs1tm1Koks
decreased body weight J:157967
Wfs1tm1Koks/Wfs1+
involves: 129S6/SvEvTac * C57BL/6
decreased body weight J:157967
impaired behavioral response to addictive substance J:145548
impaired glucose tolerance J:145548
Wfs1tm1Koks/Wfs1tm1Koks
129S6/SvEvTac-Wfs1tm1Koks
abnormal blood homeostasis J:221943
abnormal seminiferous tubule epithelium morphology J:157127
abnormal seminiferous tubule morphology J:157127
abnormal sperm flagellum morphology J:157127
abnormal sperm head morphology J:157127
abnormal spermatogonia morphology J:157127
abnormal thyroid follicle morphology J:221941
abnormal thyroid gland morphology J:221941
decreased body size J:157967
decreased body weight J:157967, J:221941, J:221943
decreased circulating glucose level J:221943
decreased circulating insulin level J:221943
decreased circulating leptin level J:221941
decreased copulatory plug deposition J:157127
decreased food intake J:221941
decreased male germ cell number J:157127
decreased Sertoli cell number J:157127
normal homeostasis/metabolism phenotype J:157127
hyperglycemia J:221943
impaired glucose tolerance J:157967, J:221943
increased circulating insulin-like growth factor I level J:157967
increased oxygen consumption J:221941
increased sperm motility J:157127
increased vertical activity J:221941
reduced male fertility J:157127
slow postnatal weight gain J:221943
weight loss J:221941, J:221943
Wfs1tm1Koks/Wfs1tm1Koks
involves: 129S6/SvEvTac * C57BL/6
abnormal behavioral response to addictive substance J:145548
abnormal cued conditioning behavior J:145548
abnormal eating behavior J:145548
abnormal spatial learning J:145548
abnormal vocalization J:145548
analgesia J:145548
normal behavior/neurological phenotype J:145548
decreased body size J:145548, J:157967
decreased body weight J:145548, J:150666, J:157967
decreased exploration in new environment J:145548
decreased locomotor activity J:145548
decreased vertical activity J:145548
impaired glucose tolerance J:145548, J:157967
impaired swimming J:145548
increased anxiety-related response J:150666
increased circulating corticosterone level J:145548
increased locomotor activity J:145548
increased thigmotaxis J:150666
prenatal lethality, incomplete penetrance J:145548
slow postnatal weight gain J:145548
Wfs1tm1Koks/Wfs1tm1Koks
involves: 129S6/SvEvTac * C57BL/6J
abnormal inner hair cell stereociliary bundle morphology J:342760
cochlear outer hair cell degeneration J:342760
impaired hearing J:342760
increased or absent threshold for auditory brainstem response J:342760
Wfs1tm1Perm/Wfs1tm1Perm
Tg(Ins2-cre)23Herr/0
involves: 129X1/SvJ * C57BL/6J * CBA/J
abnormal glucose homeostasis J:104712
abnormal pancreatic beta cell physiology J:104712
abnormal pancreatic islet morphology J:104712
decreased body weight J:104712
decreased circulating insulin level J:104712
decreased insulin secretion J:104712
decreased pancreatic beta cell mass J:104712
decreased pancreatic beta cell number J:104712
disorganized pancreatic islets J:104712
hyperglycemia J:104712
impaired glucose tolerance J:104712
Wfs1tm1Yoka/Wfs1tm1Yoka
B6.Cg-Wfs1tm1Yoka
abnormal pancreas secretion J:90420
decreased circulating insulin level J:90420
decreased pancreatic beta cell number J:90420
impaired glucose tolerance J:90420
increased glucagon secretion J:90420
Wfs1tm1Yoka/Wfs1tm1Yoka
B6J.129-Wfs1tm1Yoka
abnormal associative learning J:136108
abnormal defecation J:136108
abnormal social investigation J:136108
abnormal spatial learning J:136108
enhanced active avoidance behavior J:136108
enhanced passive avoidance behavior J:136108
increased coping response J:136108
Wfs1tm1Yoka/Wfs1tm1Yoka
involves: 129/Sv * C57BL/6
decreased pancreatic beta cell number J:90420
increased circulating glucose level J:90420
increased glucagon secretion J:90420

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory