Smarcb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smarcb1
SWI/SNF related BAF chromatin remodeling complex subunit B1
MGI:1328366

65 phenotypes from 9 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Smarcb1^em1Koke/Smarcb1^em1Koke C57BL/6-Smarcb1^em1Koke	normal cellular phenotype	J:337790
	cerebral aqueductal stenosis	J:337790
	dilated lateral ventricle	J:337790
	normal embryo phenotype	J:337790
	enlarged brain ventricles	J:337790
	normal neoplasm	J:337790
	normal nervous system phenotype	J:337790
	obstructive hydrocephaly	J:337790
	slow postnatal weight gain	J:337790
	thin cerebral cortex	J:337790
Smarcb1^{Gt(OST32815)Lex}/Smarcb1⁺ either: (involves: 129 * 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)	increased tumor incidence	J:69009, J:87955
Smarcb1^{Gt(OST32815)Lex}/Smarcb1^{Gt(OST32815)Lex} either: (involves: 129 * 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)	absent inner cell mass proliferation	J:69009
	absent trophectoderm cell proliferation	J:69009
	embryonic lethality at implantation, complete penetrance	J:69009
	failure of blastocyst to hatch from the zona pellucida	J:69009
	failure of embryo implantation	J:69009
Smarcb1^{tm1b(EUCOMM)Hmgu}/Smarcb1⁺ C57BL/6N-Smarcb1^{tm1b(EUCOMM)Hmgu}/Bay	abnormal coat appearance	J:211773
	abnormal skin coloration	J:211773
	decreased prepulse inhibition	J:211773
Smarcb1^{tm1b(EUCOMM)Hmgu}/Smarcb1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Smarcb1^{tm1b(EUCOMM)Hmgu}/Bay	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Smarcb1^tm1Gvk/Smarcb1⁺ involves: 129/Sv * C57BL/6J * SJL/J	increased blastoma incidence	J:101185
	increased brain tumor incidence	J:101185
	increased facial tumor incidence	J:101185
	increased tumor incidence	J:101185
Smarcb1^tm1Gvk/Smarcb1^tm1Gvk involves: 129/Sv * C57BL/6J * SJL/J	prenatal lethality, complete penetrance	J:101185
Smarcb1^tm1Mya/Smarcb1⁺ involves: 129S2/SvPas * C57BL/6	increased sarcoma incidence	J:68501
Smarcb1^tm1Mya/Smarcb1^tm1Mya involves: 129S2/SvPas * C57BL/6	abnormal inner cell mass apoptosis	J:68501
	embryonic lethality between implantation and somite formation, complete penetrance	J:68501
	failure of blastocyst to hatch from the zona pellucida	J:68501
	failure of embryo implantation	J:68501
	increased trophectoderm apoptosis	J:68501
Smarcb1^tm1Mya/Smarcb1^tm2Mya Tg(Alb1-cre)7Gsc/0 involves: 129S2/SvPas * FVB/N	abnormal hepatocyte morphology	J:103919
	decreased glycogen catabolism rate	J:103919
	decreased liver glycogen level	J:103919
	dissociated hepatocytes	J:103919
	hypoglycemia	J:103919
	impaired gluconeogenesis	J:103919
	increased hepatocyte proliferation	J:103919
	neonatal lethality, complete penetrance	J:103919
Smarcb1^tm1Sho/Smarcb1⁺ involves: 129S6/SvEvTac * C57BL/6	increased tumor incidence	J:66417
Smarcb1^tm1Sho/Smarcb1⁺ involves: 129S6/SvEvTac * C57BL/6J * DBA/2J	decreased tumor-free survival time	J:120820
	increased malignant tumor incidence	J:120820
Smarcb1^tm1Sho/Smarcb1^tm1Sho involves: 129S6/SvEvTac * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:66417
Smarcb1^tm1Sho/Smarcb1^tm2Sho Tg(Mx1-cre)1Cgn/? involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA	abnormal bone marrow cell morphology/development	J:80224
	bruising	J:80224
	intestinal hemorrhage	J:80224
	pancytopenia	J:80224
	premature death	J:80224
Smarcb1^tm1Sho/Smarcb1^tm3Sho Tg(Gata1-cre)1Sho/? involves: 129S1/Sv * 129S6/SvEvTac * CD-1	embryonic lethality	J:80224
Smarcb1^tm1Sho/Smarcb1^tm3Sho Tg(Mx1-cre)1Cgn/? involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA	abnormal blood cell morphology/development	J:80224
	abnormal liver morphology	J:80224
	abnormal lymph node morphology	J:80224
	abnormal spleen morphology	J:80224
	enlarged liver	J:80224
	enlarged lymph nodes	J:80224
	enlarged spleen	J:80224
	increased apoptosis	J:80224
	increased eosinophil cell number	J:80224
	increased lymphoma incidence	J:80224
	increased rhabdomyoma incidence	J:80224
	increased T cell derived lymphoma incidence	J:80224
	increased tumor incidence	J:80224
Smarcb1^tm2Sho/Smarcb1⁺ Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * C57BL/6 * SJL	decreased litter size	J:226786
	prenatal lethality, incomplete penetrance	J:226786
Smarcb1^tm2Sho/Smarcb1^tm2Sho Tg(GFAP-cre)#Gtm/0 involves: 129S1/Sv * C57BL/6 * CBA	abnormal brain white matter morphology	J:226786
	abnormal cerebellar granule cell migration	J:226786
	abnormal cerebellar Purkinje cell layer	J:226786
	abnormal corpus callosum morphology	J:226786
	axon degeneration	J:226786
	demyelination	J:226786
	normal neoplasm	J:226786
	thin cerebral cortex	J:226786
Smarcb1^tm2Sho/Smarcb1^tm2Sho Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * C57BL/6 * SJL	prenatal lethality, complete penetrance	J:226786

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