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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dkk1
dickkopf WNT signaling pathway inhibitor 1
MGI:1329040
66 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Pax3tm1(cre)Joe/Pax3+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal craniofacial development J:173125
caudal body truncation J:173125
perinatal lethality, complete penetrance J:173125
normal renal/urinary system phenotype J:173125
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Pax8tm1.1(cre)Mbu/Pax8+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal kidney collecting duct epithelium morphology J:173125
abnormal kidney medulla morphology J:173125
decreased urine creatinine level J:173125
decreased urine glucose level J:173125
decreased urine phosphate level J:173125
decreased urine potassium level J:173125
decreased urine protein level J:173125
decreased urine sodium level J:173125
elongated kidney papilla J:173125
hydronephrosis J:173125
increased kidney cell proliferation J:173125
increased urine calcium level J:173125
increased urine chloride ion level J:173125
oliguria J:173125
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Wnt4tm2(EGFP/cre)Svo/Wnt4+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		normal renal/urinary system phenotype J:173125
Dkk1tm1Lmgd/Dkk1+
involves: 129S1/Sv * 129X1/SvJ 		microcephaly J:170646
Dkk1tm1Lmgd/Dkk1tm1Lmgd
involves: 129S1/Sv * 129X1/SvJ 		rostral body truncation J:170646
Dkk1tm1Lmgd/Dkk1tm1Lmgd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal anterior head development J:71787
abnormal craniofacial development J:71787
abnormal first pharyngeal arch morphology J:119933
abnormal forelimb morphology J:71787
abnormal hindlimb morphology J:71787
abnormal limb bud morphology J:71787
abnormal mandibular prominence morphology J:71787
abnormal telencephalon morphology J:71787
absent diencephalon J:71787
absent frontonasal prominence J:71787
absent mandible J:71787
absent maxilla J:71787
absent nasal bone J:71787
absent nasal placodes J:71787
absent optic vesicle J:119933
anophthalmia J:71787
decreased forebrain size J:71787, J:119933
decreased midbrain size J:71787
ectopic digits J:71787
microcephaly J:119933
neonatal lethality, complete penetrance J:71787
polydactyly J:71787
rostral body truncation J:71787
small interparietal bone J:71787
small parietal bone J:71787
syndactyly J:71787
thick apical ectodermal ridge J:71787
Dkk1tm1Lmgd/Dkk1tm1Lmgd
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal anterior head development J:117057
Dkk1tm1Sia/Dkk1tm1Sia
involves: C57BL/6 * CBA 		abnormal embryonic neuroepithelium morphology J:122557
Gt(ROSA)26Sortm1(Dkk1)Flng/Gt(ROSA)26Sortm1(Dkk1)Flng
Tg(Msx2-cre)5Rem/0
involves: 129X1/SvJ 		absent hindlimb J:145305
short forelimb J:145305
Tg(Col1a1-Dkk1)1Hmk/?
B6.FVB-Tg(Col1a1-Dkk1)1Hmk 		abnormal bone mineralization J:158620
abnormal cell cycle J:238121
abnormal definitive hematopoiesis J:238121
abnormal hematopoietic stem cell physiology J:238121
abnormal osteoclast physiology J:158620
abnormal response to transplant J:238121
abnormal skeleton physiology J:158620
decreased bone mineral density J:158620
decreased bone ossification J:158620
decreased bone strength J:158620
decreased bone trabecula number J:158620
decreased osteoblast cell number J:158620
decreased trabecular bone connectivity density J:158620
decreased trabecular bone volume J:158620, J:238121
impaired osteoblast differentiation J:158620
increased bone trabecular spacing J:158620
increased common lymphocyte progenitor cell number J:238121
increased osteoclast cell number J:158620
insensitivity to parathyroid hormone J:158620
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory