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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dyrk1b
dual-specificity tyrosine phosphorylation regulated kinase 1b
MGI:1330302
27 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dyrk1bem1Yax/Dyrk1bem1Yax
Not Specified 		decreased response of heart to induced stress J:334531
normal mortality/aging J:334531
Dyrk1btm1b(EUCOMM)Wtsi/Dyrk1b+
C57BL/6N-Dyrk1btm1b(EUCOMM)Wtsi/Ics 		abnormal auditory brainstem response J:211773
abnormal retina inner nuclear layer morphology J:211773
abnormal retina morphology J:211773
abnormal retina outer nuclear layer morphology J:211773
decreased blood urea nitrogen level J:211773
decreased bone mineral density J:211773
decreased large unstained cell number J:211773
decreased locomotor activity J:211773
decreased lymphocyte cell number J:211773
decreased startle reflex J:211773
decreased total retina thickness J:211773
increased prepulse inhibition J:211773
Dyrk1btm1b(EUCOMM)Wtsi/Dyrk1btm1b(EUCOMM)Wtsi
C57BL/6N-Dyrk1btm1b(EUCOMM)Wtsi/Ics 		preweaning lethality, complete penetrance J:211773
Tg(Myh6-Dyrk1b)#Yax/0
involves: C57BL/6J 		abnormal mitochondrial ATP synthesis coupled electron transport J:334531
abnormal mitochondrial physiology J:334531
abnormal myocardial fiber mitochondrial morphology J:334531
abnormal response of heart to induced stress J:334531
cardiac fibrosis J:334531
decreased cardiac muscle contractility J:334531
decreased heart left ventricle muscle contractility J:334531
decreased heart left ventricle wall thickness J:334531
enlarged heart J:334531
increased heart left ventricle size J:334531
increased heart weight J:334531
lethality, incomplete penetrance J:334531
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory