Dyrk1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dyrk1b
dual-specificity tyrosine phosphorylation regulated kinase 1b
MGI:1330302

26 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dyrk1b^em1Yax/Dyrk1b^em1Yax Not Specified	decreased response of heart to induced stress	J:334531
Dyrk1b^em1Yax/Dyrk1b^em1Yax Not Specified	normal mortality/aging	J:334531
Dyrk1b^{tm1b(EUCOMM)Wtsi}/Dyrk1b⁺ C57BL/6N-Dyrk1b^{tm1b(EUCOMM)Wtsi}/Ics	abnormal auditory brainstem response	J:211773
	abnormal retina inner nuclear layer morphology	J:211773
	abnormal retina morphology	J:211773
	decreased blood urea nitrogen level	J:211773
	decreased bone mineral density	J:211773
	decreased large unstained cell number	J:211773
	decreased locomotor activity	J:211773
	decreased lymphocyte cell number	J:211773
	decreased startle reflex	J:211773
	decreased total retina thickness	J:211773
	increased prepulse inhibition	J:211773
Dyrk1b^{tm1b(EUCOMM)Wtsi}/Dyrk1b^{tm1b(EUCOMM)Wtsi} C57BL/6N-Dyrk1b^{tm1b(EUCOMM)Wtsi}/Ics	preweaning lethality, complete penetrance	J:211773
Tg(Myh6-Dyrk1b)#Yax/0 involves: C57BL/6J	abnormal mitochondrial ATP synthesis coupled electron transport	J:334531
	abnormal mitochondrial physiology	J:334531
	abnormal myocardial fiber mitochondrial morphology	J:334531
	abnormal response of heart to induced stress	J:334531
	cardiac fibrosis	J:334531
	decreased cardiac muscle contractility	J:334531
	decreased heart left ventricle muscle contractility	J:334531
	decreased heart left ventricle wall thickness	J:334531
	enlarged heart	J:334531
	increased heart left ventricle size	J:334531
	increased heart weight	J:334531
	lethality, incomplete penetrance	J:334531

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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