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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Trp63
transformation related protein 63
MGI:1330810
170 phenotypes from 20 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(KRT5-cre/PGR)1Der/0
Trp63tm2Brd/Trp63tm3.1Brd
involves: 129S7/SvEvBrd * FVB * ICR 		abnormal craniofacial morphology J:100483
abnormal epidermal layer morphology J:100483
abnormal limb morphology J:100483
abnormal skin morphology J:100483
alopecia J:100483
early cellular replicative senescence J:100483
lordokyphosis J:100483
weight loss J:100483
Trp63m1Mhda/Trp63+
C3HeB/FeJ-Trp63m1Mhda 		no abnormal phenotype detected J:82809
Trp63m1Mhda/Trp63m1Mhda
C3HeB/FeJ-Trp63m1Mhda 		abnormal craniofacial morphology J:82809
absent limbs J:82809
prenatal lethality, complete penetrance J:82809
Trp63tm1.1(cre)Ssig/Trp63+
involves: 129S/SvEv * C57BL/6 		no abnormal phenotype detected J:197339
Trp63tm1.1(cre)Ssig/Trp63tm1.1(cre)Ssig
involves: 129S/SvEv * C57BL/6 		abnormal craniofacial morphology J:197339
abnormal esophageal epithelium morphology J:197339
absent epidermis J:197339
absent limbs J:197339
Trp63tm1.1Elrf/Trp63tm1.1Elrf
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal esophageal epithelium morphology J:151638
abnormal skin physiology J:151638
abnormal urinary bladder urothelium morphology J:151638
aneuploidy J:151638
blistering J:151638
chromosomal instability J:151638
decreased hair follicle number J:151638
early cellular replicative senescence J:151638
gastric cyst J:151638
impaired wound healing J:151638
kidney cyst J:151638
kyphosis J:151638
normal mortality/aging J:151638
premature aging J:151638
premature death J:151638
spontaneous skin ulceration J:151638
Trp63tm1.1Elrf/Trp63tm1.1Elrf
involves: C57BL/6 * FVB/N 		abnormal esophageal epithelium morphology J:151638
abnormal skin physiology J:151638
abnormal urinary bladder urothelium morphology J:151638
aneuploidy J:151638
blistering J:151638
chromosomal instability J:151638
decreased hair follicle number J:151638
early cellular replicative senescence J:151638
embryonic lethality, incomplete penetrance J:151638
gastric cyst J:151638
impaired wound healing J:151638
kidney cyst J:151638
kyphosis J:151638
premature aging J:151638
premature death J:151638
spontaneous skin ulceration J:151638
Trp63tm1Aam/Trp63+
Not Specified 		abnormal phalanx morphology J:135784
ectrodactyly J:135784
Trp63tm1Aam/Trp63tm1Aam
Not Specified 		abnormal apical ectodermal ridge morphology J:135784
abnormal craniofacial morphology J:135784
abnormal ectoderm development J:135784
absent hindlimb J:135784
short forelimb J:135784
small limb buds J:135784
Trp63tm1Brd/Trp63tm1Brd
involves: 129S7/SvEvBrd 		abnormal skin physiology J:151638
Trp63tm1Brd/Trp63tm1Brd
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal epidermal layer morphology J:54636
abnormal facial morphology J:54636
abnormal humerus morphology J:54636
abnormal limb bone morphology J:54636
abnormal pelvic girdle bone morphology J:54636
abnormal phalanx morphology J:54636
abnormal skin condition J:54636
abnormal skin physiology J:54636
absent apical ectodermal ridge J:54636
absent carpal bone J:54636
absent epidermis stratum corneum J:54636
absent epidermis stratum granulosum J:54636
absent epidermis stratum spinosum J:54636
absent hair follicles J:54636
absent hindlimb J:54636
absent radius J:54636
absent teeth J:54636
absent ulna J:54636
impaired skin barrier function J:54636
neonatal lethality, complete penetrance J:54636
shiny skin J:54636
short forelimb J:54636
small limb buds J:54636
translucent skin J:54636
Trp63tm1Cmis/Trp63+
involves: 129P2/OlaHsd * C57BL/6 		abnormal epidermal layer morphology J:191121
abnormal keratinocyte physiology J:191121
blistering J:191121
cleft palate J:191121
neonatal lethality, complete penetrance J:191121
Trp63tm1Elrf/Trp63tm1Elrf
Tg(KRT14-cre)8Brn/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * FVB/N 		normal homeostasis/metabolism phenotype J:151638
normal integument phenotype J:151638
Trp63tm1Fmc/Trp63+
involves: 129S4/SvJae 		abnormal female reproductive system morphology J:79340
small uterus J:79340
Trp63tm1Fmc/Trp63+
involves: 129S4/SvJae * C57BL/6 		increased histiocytic sarcoma incidence J:98958
increased lung adenoma incidence J:98958
increased malignant tumor incidence J:98958
increased squamous cell carcinoma incidence J:98958
increased tumor incidence J:98958
intervertebral disk degeneration J:98958
premature aging J:98958
premature death J:98958
Trp63tm1Fmc/Trp63tm1Fmc
involves: 129S2/SvPas * BALB/c 		normal reproductive system phenotype J:116176
Trp63tm1Fmc/Trp63tm1Fmc
involves: 129S4/SvJae 		abnormal craniofacial morphology J:79340
abnormal esophageal epithelium morphology J:54637
abnormal esophageal squamous epithelium morphology J:54637
abnormal female reproductive system morphology J:79340
abnormal forelimb morphology J:54637
abnormal hair shaft morphology J:54637
abnormal limb bud morphology J:54637
abnormal limb development J:54637
abnormal prostate gland branching morphogenesis J:66126
abnormal secondary palate development J:54637
abnormal septation of the cloaca J:79340
abnormal stomach epithelium morphology J:173368
abnormal stomach non-glandular epithelium morphology J:54637
abnormal urinary bladder urothelium morphology J:79341
abnormal uterine cervix epithelium morphology J:54637
abnormal vagina epithelium morphology J:54637
abnormal ventral body wall morphology J:79340
absent apical ectodermal ridge J:54637
absent carpal bone J:54637
absent epidermis J:54637, J:79340
absent eyelids J:54637
absent hair follicles J:54637
absent hindlimb J:54637
absent lacrimal glands J:54637
absent limbs J:79340
absent mammary gland J:54637
absent ovary J:79340
absent oviduct J:79340
absent prostate gland J:66126
absent radius J:54637
absent salivary gland J:54637
absent sebaceous gland J:54637
absent tongue squamous epithelium J:54637
absent tooth placode J:54637
absent urinary bladder urothelium J:54637
absent vibrissae J:54637
adactyly J:54637
clitoris hypoplasia J:79340
decreased apoptosis J:178316
esophagogastric junction metaplasia J:173368
gastric metaplasia J:173368
increased apoptosis J:54637
neonatal lethality, complete penetrance J:54637
rectovaginal fistula J:79340
small limb buds J:54637
small mandible J:54637
small maxilla J:54637
small tail bud J:79340
thin urinary bladder urothelium J:54637
Trp63tm1Fmc/Trp63tm1Fmc
involves: 129S4/SvJae * C57BL/6 		abnormal esophageal squamous epithelium morphology J:95347
abnormal esophagus development J:95347
abnormal respiratory epithelium morphology J:95347
abnormal tracheal ciliated epithelium morphology J:95347
Trp63tm1Sin/Trp63tm1Sin
involves: C57BL/6 		abnormal limb morphology J:173538
abnormal olfactory epithelium morphology J:173538
abnormal skin morphology J:173538
Trp63tm1Sin/Trp63tm1Sin
Not Specified 		abnormal craniofacial development J:181275
abnormal embryo development J:181275
abnormal keratinocyte differentiation J:181275
abnormal keratinocyte morphology J:181275
abnormal keratinocyte physiology J:181275
abnormal limb development J:181275
abnormal periderm morphology J:315539
abnormal secondary palate development J:315539
abnormal skin development J:181275
absent epidermis J:181275
absent hair follicles J:181275
absent sebaceous gland J:181275
cleft palate J:315539
decreased fetal size J:181275
decreased keratinocyte proliferation J:181275
dehydration J:181275
neonatal lethality, complete penetrance J:181275
Trp63tm2.1Aam/Trp63tm2.1Aam
Not Specified 		abnormal cellular replicative senescence J:158291
normal embryo phenotype J:158291
normal neoplasm J:158291
Trp63tm2.1Aam/Trp63tm3.1Aam
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 		abnormal epidermal layer morphology J:294158
cleft palate J:294158
normal limbs/digits/tail phenotype J:294158
thick dermal layer J:294158
thick epidermis J:294158
thick epidermis stratum basale J:294158
thick epidermis stratum spinosum J:294158
Trp63tm2.1Aam/Trp63tm3.2Aam
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 		cleft palate J:294158
normal limbs/digits/tail phenotype J:294158
thick epidermis J:294158
Trp63tm2.1Aam/Trp63tm3Aam
involves: 129S7/SvEvBrd 		abnormal epidermal layer morphology J:294158
abnormal limb morphology J:294158
cleft palate J:294158
ectrodactyly J:294158
thick dermal layer J:294158
thick epidermis stratum basale J:294158
thick epidermis stratum spinosum J:294158
Trp63tm2.2Elrf/Trp63+
Not Specified 		abnormal epidermis stratum basale morphology J:206433
wrinkled skin J:206433
Trp63tm2.2Elrf/Trp63tm2.2Elrf
Not Specified 		abnormal epidermal layer morphology J:206433
abnormal epidermis stratum basale morphology J:206433
abnormal epidermis stratum spinosum morphology J:206433
dermal-epidermal separation J:206433
neonatal lethality, complete penetrance J:206433
Trp63tm2Aam/Trp63tm2Aam
Not Specified 		abnormal cellular replicative senescence J:158291
Trp63tm2Brd/Trp63+
B6.129S7-Trp63tm2Brd/J 		abnormal horizontal basal cell of olfactory epithelium morphology J:173538
Trp63tm2Brd/Trp63+
involves: 129S7/SvEvBrd 		abnormal cornea epithelium morphology J:100483
abnormal rectum morphology J:100483
abnormal tongue epithelium morphology J:100483
abnormal uterine cervix epithelium morphology J:100483
acanthosis J:100483
alopecia J:100483
circling J:100483
distended abdomen J:100483
enlarged lymph nodes J:100483
hemorrhage J:100483
increased susceptibility to infection J:100483
kidney inflammation J:100483
premature aging J:100483
premature death J:100483
rectal prolapse J:100483
skin lesions J:100483
spontaneous skin ulceration J:100483
uterine cervix inflammation J:100483
weakness J:100483
Trp63tm2Brd/Trp63tm2Brd
B6.129S7-Trp63tm2Brd/J 		abnormal horizontal basal cell of olfactory epithelium morphology J:173538
abnormal olfactory epithelium morphology J:173538
abnormal olfactory gland morphology J:173538
Trp63tm2Brd/Trp63tm2Brd
involves: 129S7/SvEvBrd 		abnormal apical ectodermal ridge morphology J:135784
abnormal craniofacial morphology J:100483
abnormal epidermal layer morphology J:100483
abnormal limb morphology J:100483
abnormal skin morphology J:100483
decreased cell proliferation J:100483
early cellular replicative senescence J:100483
normal muscle phenotype J:98439
Trp63tm2Brd/Trp63tm2Brd
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal abdominal wall morphology J:119657
abnormal anus morphology J:119657
abnormal epidermal layer morphology J:54636
abnormal facial morphology J:54636
abnormal hair follicle development J:54636
abnormal humerus morphology J:54636
abnormal limb bone morphology J:54636
abnormal mitochondrial physiology J:119657
abnormal pelvic girdle bone morphology J:54636
abnormal phalanx morphology J:54636
abnormal primitive urogenital sinus morphology J:119657
abnormal reproductive system morphology J:119657
abnormal skin condition J:54636
abnormal skin physiology J:54636
abnormal urinary bladder detrusor smooth muscle morphology J:119657
abnormal urinary bladder urothelium morphology J:119657
absent apical ectodermal ridge J:54636
absent carpal bone J:54636
absent epidermis stratum corneum J:54636
absent epidermis stratum granulosum J:54636
absent epidermis stratum spinosum J:54636
absent hindlimb J:54636
absent pubic symphysis J:119657
absent radius J:54636
absent teeth J:54636
absent ulna J:54636
absent urinary bladder urothelium J:119657
distended urinary bladder J:119657
impaired skin barrier function J:54636
increased apoptosis J:119657
neonatal lethality, complete penetrance J:54636
shiny skin J:54636
short forelimb J:54636
small limb buds J:54636
translucent skin J:54636
umbilical hernia J:119657
urinary bladder exstrophy J:119657
Trp63tm2Fmc/Trp63tm2Fmc
involves: BALB/c 		decreased cellular sensitivity to ionizing radiation J:116176
Trp63tm3.1Aam/Trp63+
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 		abnormal keratinocyte physiology J:294158
cleft palate J:294158
decreased keratinocyte proliferation J:294158
Trp63tm3.1Aam/Trp63tm3.1Aam
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 		abnormal embryo development J:294158
abnormal limb morphology J:294158
abnormal skin development J:294158
perinatal lethality, complete penetrance J:294158
short limbs J:294158
Trp63tm3.1Brd/Trp63tm3.1Brd
involves: 129S7/SvEvBrd 		decreased cell proliferation J:100483
early cellular replicative senescence J:100483
Trp63tm3.2Aam/Trp63+
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 		normal craniofacial phenotype J:294158
preweaning lethality, incomplete penetrance J:294158
Trp63tm3.2Aam/Trp63tm3.2Aam
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 		abnormal embryo development J:294158
abnormal limb morphology J:294158
abnormal skin development J:294158
perinatal lethality, complete penetrance J:294158
short limbs J:294158
Trp63tm3.2Brd/Trp63tm3.2Brd
involves: 129S7/SvEvBrd 		absent hair follicles J:75125
absent hindlimb J:75125
short forelimb J:75125
Trp63tm3Aam/Trp63+
involves: 129S7/SvEvBrd 		abnormal eye morphology J:294158
abnormal keratinocyte physiology J:294158
abnormal limb morphology J:294158
abnormal palatal shelf fusion at midline J:294158
abnormal tooth development J:294158
abnormal tooth root morphology J:294158
absent gastric milk in neonates J:294158
alopecia J:294158
cleft palate J:294158
decreased keratinocyte proliferation J:294158
nail dystrophy J:294158
perinatal lethality, incomplete penetrance J:294158
ruffled hair J:294158
supernumerary teeth J:294158
Trp63tm3Aam/Trp63tm3Aam
involves: 129S7/SvEvBrd 		abnormal embryo development J:294158
abnormal limb morphology J:294158
abnormal skin development J:294158
perinatal lethality, complete penetrance J:294158
short limbs J:294158
Trp63tm3Brd/Trp63tm3Brd
involves: 129S7/SvEvBrd 		no abnormal phenotype detected J:75125
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory