Trp63 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Trp63
transformation related protein 63
MGI:1330810

26 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Dlx5^tm1Levi/Dlx5/Dlx6^tm1Levi Trp63^tm1Aam/Trp63^tm1Aam involves: 129P2/OlaHsd	abnormal phalanx morphology	J:135784
	ectrodactyly	J:135784
	monodactyly	J:135784
	syndactyly	J:135784
Kdf1^shd/Kdf1^shd Trp63^tm2Brd/Trp63⁺ involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J	normal integument phenotype	J:203995
	normal limbs/digits/tail phenotype	J:203995
Trp53^tm1Tyj/Trp53⁺ Trp63^tm1Fmc/Trp63⁺ involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	increased chronic myelocytic leukemia incidence	J:98958
	increased mammary adenocarcinoma incidence	J:98958
	increased metastatic potential	J:98958
	increased osteosarcoma incidence	J:98958
	increased rhabdomyosarcoma incidence	J:98958
	increased squamous cell carcinoma incidence	J:98958
	increased T cell derived lymphoma incidence	J:98958
	increased tumor incidence	J:98958
	increased urinary bladder transitional cell carcinoma incidence	J:98958
	intervertebral disk degeneration	J:98958
	premature aging	J:98958
	premature death	J:98958
Trp53^tm1Tyj/Trp53^tm1Tyj Trp63^tm1.1Elrf/Trp63^tm1.1Elrf either: (involves: 129S2/SvPas * C57BL/6 * FVB/N) or (involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6)	abnormal skin physiology	J:151638
	early cellular replicative senescence	J:151638
Trp63^tm1Aam/Trp63^tm1Aam Dlx5^tm1Levi/Dlx5/Dlx6^tm1Levi involves: 129P2/OlaHsd	abnormal phalanx morphology	J:135784
	ectrodactyly	J:135784
	monodactyly	J:135784
	syndactyly	J:135784
Trp63^tm1Fmc/Trp63⁺ Trp73^tm1Fmc/Trp73⁺ involves: 129S4/SvJae * C57BL/6	increased carcinoma incidence	J:98958
	increased chronic myelocytic leukemia incidence	J:98958
	increased hemangiosarcoma incidence	J:98958
	increased lung adenocarcinoma incidence	J:98958
	increased lung adenoma incidence	J:98958
	increased mammary adenocarcinoma incidence	J:98958
	increased metastatic potential	J:98958
	increased salivary gland adenoma incidence	J:98958
	increased squamous cell carcinoma incidence	J:98958
	increased T cell derived lymphoma incidence	J:98958
	increased tumor incidence	J:98958
	intervertebral disk degeneration	J:98958
	paralysis	J:98958
	premature aging	J:98958
	premature death	J:98958

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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