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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lgmn
legumain
MGI:1330838
46 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lgmntm1b(NCOM)Mfgc/Lgmntm1b(NCOM)Mfgc
C57BL/6N-Lgmntm1b(NCOM)Mfgc/Tcp 		decreased body length J:211773
decreased prepulse inhibition J:211773
short tibia J:211773
Lgmntm1Cptr/Lgmntm1Cptr
B6.129S6-Lgmntm1Cptr 		abnormal adaptive immunity J:155339
abnormal kidney interstitium morphology J:172774
abnormal kidney outer medulla outer stripe morphology J:172774
abnormal kidney physiology J:172774
abnormal proximal convoluted tubule morphology J:172774
abnormal renal glomerulus morphology J:172774
albuminuria J:172774
decreased interleukin-6 secretion J:155339
decreased interleukin-12b secretion J:155339
decreased renal glomerular filtration rate J:172774
decreased tumor necrosis factor secretion J:155339
enlarged spleen J:172774
hydronephrosis J:172774
increased circulating creatinine level J:172774
increased urine protein level J:172774
kidney cortex atrophy J:172774
lysosomal protein accumulation J:172774
pale kidney J:172774
renal glomerulus cyst J:172774
renal interstitial fibrosis J:172774
renal tubule atrophy J:172774
slow postnatal weight gain J:172774
Lgmntm1Ihn/Lgmntm1Ihn
involves: 129P2/OlaHsd * C57BL/6 		abnormal bone marrow cell morphology/development J:143886
abnormal erythrocyte morphology J:143886
abnormal macrophage physiology J:143886
abnormal NK cell physiology J:143886
abnormal spleen morphology J:143886
anemia J:143886
decreased erythrocyte cell number J:143886
decreased hematocrit J:143886
decreased hemoglobin content J:143886
decreased mean corpuscular hemoglobin J:143886
decreased mean corpuscular hemoglobin concentration J:143886
extramedullary hematopoiesis J:143886
normal immune system phenotype J:143886
increased body temperature J:143886
increased circulating tumor necrosis factor level J:143886
increased liver weight J:143886
increased lymphocyte cell number J:143886
increased spleen weight J:143886
reticulocytosis J:143886
Lgmntm1Ihn/Lgmntm1Ihn
involves: 129P2/OlaHsd * C57BL/6J 		accumulation of giant lysosomes in kidney/renal tubule cells J:85207
decreased body weight J:85207
slow postnatal weight gain J:85207
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory