Lin7c Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lin7c
lin-7 homolog C, crumbs cell polarity complex component
MGI:1330839

16 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lin7c^tm1Dsb/Lin7c^tm1Dsb involves: 129S1/Sv * 129X1/SvJ	abnormal kidney morphology	J:134806
	abnormal kidney physiology	J:134806
	abnormal renal tubule epithelium morphology	J:134806
	decreased body weight	J:134806
	decreased creatinine clearance	J:134806
	decreased kidney weight	J:134806
	decreased urine osmolality	J:134806
	dilated renal tubule	J:134806
	increased blood urea nitrogen level	J:134806
	increased kidney apoptosis	J:134806
	increased urine sodium level	J:134806
	polycystic kidney	J:134806
	polyuria	J:134806
	renal interstitial fibrosis	J:134806
	single kidney	J:134806
Lin7c^tm2Dsb/Lin7c^tm2Dsb Tg(Hoxb7-cre)13Amc/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:134806
Lin7c^tm2Dsb/Lin7c^tm2Dsb Tg(Pax3-cre)1Joe/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	decreased kidney weight	J:134806
	dilated renal tubule	J:134806
	increased kidney apoptosis	J:134806
	renal interstitial fibrosis	J:134806

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24