Soat2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Soat2
sterol O-acyltransferase 2
MGI:1332226

16 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Soat2^tm1.1Llr/Soat2^tm1.1Llr involves: 129S/SvEv	normal digestive/alimentary phenotype	J:184908
Soat2^tm1.1Llr/Soat2^tm1.1Llr Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA	decreased circulating cholesterol level	J:184908
	decreased circulating LDL cholesterol level	J:184908
	decreased circulating VLDL cholesterol level	J:184908
	decreased liver cholesterol level	J:184908
	decreased liver triglyceride level	J:184908
	normal digestive/alimentary phenotype	J:184908
	increased circulating triglyceride level	J:184908
Soat2^tm1.1Llr/Soat2^tm1.1Llr Tg(Vil1-cre)997Gum/0 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL	decreased cholesterol level	J:184908
	decreased circulating cholesterol level	J:184908
	decreased circulating VLDL cholesterol level	J:184908
	decreased intestinal cholesterol absorption	J:184908
	decreased liver cholesterol level	J:184908
	decreased liver triglyceride level	J:184908
	increased cholesterol level	J:184908
	increased circulating triglyceride level	J:184908
Soat2^tm1Far/Soat2^tm1Far involves: 129S4/SvJae * C57BL/6J	abnormal bile composition	J:82032
	abnormal cholesterol homeostasis	J:82032
	abnormal gallbladder physiology	J:82032
	abnormal small intestine morphology	J:82032
	decreased circulating cholesterol level	J:82032
	decreased circulating LDL cholesterol level	J:82032
	decreased circulating VLDL cholesterol level	J:82032
	decreased intestinal cholesterol absorption	J:82032
	decreased susceptibility to diet-induced hepatic steatosis	J:82032
	increased circulating HDL cholesterol level	J:82032
	increased circulating triglyceride level	J:82032

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24