Ccr6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ccr6
C-C motif chemokine receptor 6
MGI:1333797

58 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ccr6^tm1(EGFP)Irw/Ccr6^tm1(EGFP)Irw B6.129S6-Ccr6^tm1(EGFP)Irw	decreased interleukin-4 secretion	J:132012
	decreased interleukin-12 secretion	J:132012
	decreased susceptibility to bacterial infection	J:132012
	decreased tumor necrosis factor secretion	J:132012
	increased interferon-gamma secretion	J:132012
Ccr6^tm1(EGFP)Irw/Ccr6^tm1(EGFP)Irw involves: 129S6/SvEvTac * C57BL/6	abnormal alpha-beta intraepithelial T cell morphology	J:85086
	abnormal B cell physiology	J:120122
	abnormal CD4-positive, alpha-beta intraepithelial T cell morphology	J:85086
	abnormal CD8 positive, alpha-beta intraepithelial T cell morphology	J:85086
	abnormal follicular dendritic cell physiology	J:113363
	abnormal gut-associated lymphoid tissue morphology	J:113363, J:120122
	abnormal Peyer's patch morphology	J:120122
	abnormal T cell physiology	J:85086
	decreased B cell number	J:120122
	decreased Peyer's patch number	J:120122
	impaired B cell migration	J:120122
	increased T cell proliferation	J:85086
Ccr6^{tm1.1(KOMP)Vlcg}/Ccr6^{tm1.1(KOMP)Vlcg} C57BL/6N-Ccr6^{tm1.1(KOMP)Vlcg}/Ucd	abnormal spleen morphology	J:211773
	decreased heart rate	J:211773
	hyperactivity	J:211773
	prolonged RR interval	J:211773
Ccr6^tm1.1Jmf/Ccr6^tm1.1Jmf B6.129-Ccr6^tm1.1Jmf	abnormal CD4-positive, alpha-beta T cell physiology	J:152716
	abnormal dendritic cell physiology	J:152716
	abnormal interleukin secretion	J:152716
	decreased inflammatory response	J:152716
Ccr6^tm1Dgen/Ccr6^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679
Ccr6^tm1Gma/Ccr6^tm1Gma involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:68191
	abnormal myeloid dendritic cell morphology	J:68191
	abnormal Peyer's patch follicle morphology	J:68191
	abnormal Peyer's patch morphology	J:68191
	decreased inflammatory response	J:68191
	decreased leukocyte cell number	J:68191
	increased leukocyte cell number	J:68191
Ccr6^tm1Gma/Ccr6^tm1Gma Tg(Rorc-EGFP)1Ebe/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal effector T cell morphology	J:137020
Ccr6^tm1Lira/Ccr6^tm1Lira B6.129-Ccr6^tm1Lira	decreased IgE level	J:71096
	decreased interleukin-5 secretion	J:71096
	decreased susceptibility to type I hypersensitivity reaction	J:71096
	impaired eosinophil recruitment	J:71096
Ccr6^tm1Lira/Ccr6^tm1Lira involves: 129	abnormal follicular dendritic cell antigen presentation	J:113363
	abnormal Peyer's patch T cell area morphology	J:113363
	abnormal T cell physiology	J:123150
Ccr6^tm1Lira/Ccr6^tm1Lira involves: 129 * C57BL/6	abnormal CD4-positive, alpha beta T cell morphology	J:148286
	abnormal CD4-positive, alpha-beta T cell physiology	J:148286
	abnormal choroid plexus morphology	J:148286
	abnormal gut-associated lymphoid tissue morphology	J:76461
	abnormal intraepithelial T cell number	J:76461
	abnormal lymphocyte morphology	J:148286
	abnormal macrophage physiology	J:124358
	abnormal myeloid dendritic cell morphology	J:124358
	abnormal peritoneal macrophage morphology	J:124358
	abnormal Peyer's patch germinal center morphology	J:76461
	abnormal Peyer's patch morphology	J:76461
	decreased B cell number	J:148286
	decreased CD4-positive, alpha-beta T cell number	J:148286
	decreased CD8-positive, alpha-beta T cell number	J:148286
	decreased IgA level	J:76461
	decreased IgG3 level	J:76461
	decreased inflammatory response	J:124358
	decreased interleukin-10 secretion	J:124358
	decreased interleukin-12 secretion	J:124358
	decreased macrophage cytokine production	J:124358
	decreased macrophage nitric oxide production	J:124358
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:148286
	decreased tumor necrosis factor secretion	J:124358
	increased activated T cell number	J:76461
	increased B-1 B cell number	J:124358
	increased double-positive T cell number	J:76461
	increased IgM level	J:76461
	increased susceptibility to Riboviria infection	J:76461
	increased T cell number	J:76461

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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