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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cx3cr1
C-X3-C motif chemokine receptor 1
MGI:1333815
51 phenotypes from 4 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cx3cr1em1(IMPC)Mbp/Cx3cr1em1(IMPC)Mbp
C57BL/6N-Cx3cr1em1(IMPC)Mbp/MbpMmucd 		abnormal caudal vertebrae morphology J:211773
abnormal kidney morphology J:211773
enlarged kidney J:211773
small kidney J:211773
Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
involves: 129S4/SvJae * C57BL/6 		abnormal NK cell physiology J:82033
abnormal response to transplant J:82033
normal immune system phenotype J:82033
impaired macrophage chemotaxis J:82033
Cx3cr1tm1Litt/Cx3cr1+
B6.129P2-Cx3cr1tm1Litt 		increased susceptibility to experimental autoimmune encephalomyelitis J:129712
microgliosis J:110266
paresis J:129712
Cx3cr1tm1Litt/Cx3cr1tm1Litt
B6.129P2(Cg)-Cx3cr1tm1Litt/J 		normal homeostasis/metabolism phenotype J:139390
Cx3cr1tm1Litt/Cx3cr1tm1Litt
B6.129P2-Cx3cr1tm1Litt 		abnormal leukocyte physiology J:124722
abnormal microglial cell morphology J:265696
abnormal microglial cell physiology J:110266, J:265696
abnormal NK cell physiology J:129712
abnormal ocular fundus morphology J:265696
abnormal photoreceptor connecting cilium morphology J:265696
abnormal retina outer nuclear layer morphology J:265696
abnormal retina photoreceptor morphology J:265696
abnormal vascular wound healing J:124722
brain inflammation J:129712
brainstem hemorrhage J:129712
decreased a-wave amplitude J:265696
decreased b-wave amplitude J:265696
decreased NK cell number J:129712
decreased retina cone cell number J:265696
decreased vascular smooth muscle cell proliferation J:124722
demyelination J:129712
normal immune system phenotype J:129712
increased neuron apoptosis J:110266
increased susceptibility to dopaminergic neuron neurotoxicity J:110266
increased susceptibility to experimental autoimmune encephalomyelitis J:129712
increased susceptibility to induced morbidity/mortality J:129712
microgliosis J:110266
paralysis J:129712
retina cone cell degeneration J:265696
retina degeneration J:265696
retina gliosis J:265696
retina outer nuclear layer degeneration J:265696
short photoreceptor outer segment J:265696
Cx3cr1tm1Litt/Cx3cr1tm1Litt
C.129P2-Cx3cr1tm1Litt 		normal immune system phenotype J:84544
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd 		abnormal dendritic cell physiology J:95694, J:271242
abnormal small intestinal villus morphology J:95694
decreased inflammatory response J:271242
increased dendritic cell number J:210086
increased susceptibility to bacterial infection induced morbidity/mortality J:95694
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * C57BL/6 		abnormal leukocyte physiology J:162714
abnormal retina morphology J:127548
choroidal neovascularization J:127548
decreased monocyte cell number J:145036
decreased susceptibility to kidney reperfusion injury J:162714
normal immune system phenotype J:84544
impaired macrophage chemotaxis J:162714
normal nervous system phenotype J:84544
Cx3cr1tm1Zm/Cx3cr1tm1Zm
C.129-Cx3cr1tm1Zm 		abnormal retina morphology J:127548
abnormal retina photoreceptor layer morphology J:127548
retina degeneration J:127548
Cx3cr1tm1Zm/Cx3cr1tm1Zm
involves: 129 * C57BL/6 		abnormal retina morphology J:127548
abnormal retina photoreceptor layer morphology J:127548
choroidal neovascularization J:127548
retina degeneration J:127548
retina deposits J:127548
thin retina outer nuclear layer J:127548
Cx3cr1tm1Zm/Cx3cr1tm1Zm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal splenocyte physiology J:103047
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory