Mbd4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mbd4
methyl-CpG binding domain protein 4
MGI:1333850

30 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mbd4/Ift122^tm1Abc/Mbd4⁺ B6.129-Mbd4/Ift122^tm1Abc	decreased embryonic cilium length	J:143544
Mbd4/Ift122^tm1Abc/Mbd4/Ift122^tm1Abc B6.129-Mbd4/Ift122^tm1Abc	abnormal abdominal wall morphology	J:143544
	abnormal cilium morphology	J:143544
	abnormal direction of heart looping	J:143544
	abnormal eye development	J:143544
	abnormal head morphology	J:143544
	abnormal left-right axis patterning	J:143544
	abnormal limb development	J:143544
	abnormal neural tube morphology	J:143544
	abnormal pharyngeal arch development	J:143544
	abnormal ventral interneuron 3 morphology	J:143544
	absent embryonic cilia	J:143544
	delayed embryo turning	J:143544
	delayed limb development	J:143544
	ectrodactyly	J:143544
	elongated neck	J:143544
	embryonic lethality during organogenesis, complete penetrance	J:143544
	enlarged heart	J:143544
	exencephaly	J:143544
	hemorrhage	J:143544
	increased motor neuron number	J:143544
	open neural tube	J:143544
	polysyndactyly	J:143544
	right-sided stomach	J:143544
	situs inversus	J:143544
Mbd4/Ift122^tm1Abc/Mbd4/Ift122^tm1Abc either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal cell cycle checkpoint function	J:86981
	decreased physiological sensitivity to xenobiotic	J:86981
	decreased sensitivity to induced cell death	J:86981
Mbd4^tm1Bird/Mbd4^tm1Bird involves: 129P2/OlaHsd * C57BL/6	abnormal cell physiology	J:77896
Mbd4^tm1Wed/Mbd4^tm1Wed B6.Cg-Mbd4^tm1Wed/J	abnormal DNA methylation	J:175891
Mbd4^tm1Wed/Mbd4^tm1Wed involves: 129/Sv * C57BL/6 * SJL	abnormal cell physiology	J:80319
Mbd4^tm2Abc/Mbd4^tm2Abc involves: 129/Sv * 129X1/SvJ * C57BL/6	abnormal cell cycle checkpoint function	J:86981
	decreased physiological sensitivity to xenobiotic	J:86981
	decreased sensitivity to induced cell death	J:86981

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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