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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bub1b
BUB1B, mitotic checkpoint serine/threonine kinase
MGI:1333889
79 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bub1bGt(neo-btk)1Dai/Bub1b+
involves: 129S4/SvJae 		abnormal mitotic spindle assembly checkpoint J:88094
increased colon adenoma incidence J:88094
increased intestinal adenocarcinoma incidence J:88094
Bub1bGt(neo-btk)1Dai/Bub1b+
involves: 129S4/SvJae * C57BL/6 		abnormal definitive hematopoiesis J:88223
abnormal megakaryocyte differentiation J:88223
absent common myeloid progenitor cells J:88223
decreased erythrocyte cell number J:88223
normal embryo phenotype J:88223
enlarged spleen J:88223
Bub1bGt(neo-btk)1Dai/Bub1bGt(neo-btk)1Dai
involves: 129S4/SvJae * C57BL/6 		abnormal blastocyst morphology J:88223
embryonic lethality between implantation and placentation, complete penetrance J:88223
increased embryonic tissue cell apoptosis J:88223
Bub1btm1.1Hsl/Bub1b+
involves: 129 * C57BL/6 		enlarged spleen J:201641
increased adenocarcinoma incidence J:201641
increased B cell derived lymphoma incidence J:201641
increased B cell proliferation J:201641
increased fibrosarcoma incidence J:201641
increased hemangiosarcoma incidence J:201641
increased hepatocellular carcinoma incidence J:201641
increased incidence of induced tumors J:201641
increased leukemia incidence J:201641
increased lung adenocarcinoma incidence J:201641
increased lymphoma incidence J:201641
increased rectum adenocarcinoma incidence J:201641
increased sarcoma incidence J:201641
increased spleen white pulp amount J:201641
normal mortality/aging J:201641
Bub1btm1.1Hsl/Bub1b+
Tg(HIST1H2BB/EGFP)1Pa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell nucleus morphology J:201641
abnormal mitosis J:201641
abnormal mitotic spindle assembly checkpoint J:201641
aneuploidy J:201641
Bub1btm1.1Hsl/Bub1btm1.1Hsl
involves: 129 * C57BL/6 		abnormal embryo development J:201641
embryonic growth retardation J:201641
embryonic lethality between implantation and somite formation, complete penetrance J:201641
increased apoptosis J:201641
Bub1btm1.1Jvd/Bub1b+
involves: 129S6/SvEvTac 		abnormal cell cycle checkpoint function J:105717
premature death J:194926
Bub1btm1.1Jvd/Bub1b+
involves: 129S6/SvEvTac * C57BL/6 		abnormal mitosis J:293084
abnormal mitotic spindle assembly checkpoint J:293084
aneuploidy J:293084
decreased tumor latency J:293084
increased tumor growth/size J:293084
normal neoplasm J:293084
premature death J:293084
Bub1btm1.1Jvd/Bub1btm1.1Jvd
involves: 129S6/SvEvTac 		embryonic lethality, complete penetrance J:91128
Bub1btm1Jvd/Bub1b+
involves: 129S6/SvEvTac 		abnormal cell cycle checkpoint function J:105717
Bub1btm1Jvd/Bub1btm1.1Jvd
involves: 129S6/SvEvTac 		neonatal lethality, complete penetrance J:91128
Bub1btm1Jvd/Bub1btm1.1Jvd
involves: 129S6/SvEvTac * C57BL/6 		neonatal lethality, complete penetrance J:293084
Bub1btm1Jvd/Bub1btm1Jvd
involves: 129S6/SvEvTac 		abnormal cell cycle checkpoint function J:105717
abnormal cell physiology J:91128
abnormal cellular replicative senescence J:91128, J:105717
abnormal mitosis J:105717
cachexia J:91128
cataract J:91128
chromosome breakage J:91128
decreased subcutaneous adipose tissue amount J:91128
decreased total body fat amount J:91128
female infertility J:91128
impaired wound healing J:91128
lordokyphosis J:91128
male infertility J:91128
muscular atrophy J:91128
oligozoospermia J:91128
postnatal growth retardation J:91128
premature death J:91128
thin dermal layer J:91128
Bub1btm1Jvd/Bub1btm1Jvd
involves: 129S6/SvEvTac * C57BL/6 		abnormal mitosis J:293084
abnormal mitotic spindle assembly checkpoint J:293084
abnormal mitotic spindle morphology J:293084
aneuploidy J:293084
cataract J:293084
decreased fat cell size J:293084
decreased grip strength J:293084
early cellular replicative senescence J:293084
impaired exercise endurance J:293084
increased response of heart to induced stress J:293084
kyphosis J:293084
lipodystrophy J:293084
premature aging J:293084
premature death J:293084
skeletal muscle fiber atrophy J:293084
Bub1btm1Jvd/Bub1btm1Jvd
involves: 129S6/SvEvTac * C57BL/6 * FVB 		abnormal hepatocyte physiology J:234643
aneuploidy J:234643
hypoglycemia J:234643
improved glucose tolerance J:234643
increased insulin sensitivity J:234643
postnatal growth retardation J:234643
Bub1btm1Jvd/Bub1btm2.1Jvd
involves: 129S6/SvEvTac * C57BL/6 		abnormal mitosis J:293084
abnormal mitotic spindle assembly checkpoint J:293084
abnormal mitotic spindle morphology J:293084
aneuploidy J:293084
neonatal lethality, complete penetrance J:293084
Bub1btm1Jvd/Bub1btm3.1Jvd
involves: 129S6/SvEvTac * C57BL/6 		abnormal mitosis J:293084
abnormal mitotic spindle assembly checkpoint J:293084
abnormal mitotic spindle morphology J:293084
aneuploidy J:293084
cataract J:293084
decreased fat cell size J:293084
decreased grip strength J:293084
early cellular replicative senescence J:293084
impaired exercise endurance J:293084
increased incidence of tumors by chemical induction J:293084
increased response of heart to induced stress J:293084
increased tumor growth/size J:293084
kyphosis J:293084
lipodystrophy J:293084
normal neoplasm J:293084
postnatal growth retardation J:293084
premature aging J:293084
premature death J:293084
skeletal muscle fiber atrophy J:293084
Bub1btm2.1Jvd/Bub1b+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal fat pad morphology J:194926
abnormal mitosis J:194926
aneuploidy J:194926
normal cardiovascular system phenotype J:194926
cataract J:194926
decreased body weight J:194926
decreased fat cell size J:194926
decreased inguinal fat pad weight J:194926
decreased mesenteric fat pad weight J:194926
decreased skeletal muscle fiber diameter J:194926
decreased subcutaneous adipose tissue amount J:194926
decreased total body fat amount J:194926
early cellular replicative senescence J:194926
impaired exercise endurance J:194926
increased tumor growth/size J:194926
lordokyphosis J:194926
muscular atrophy J:194926
normal neoplasm J:194926
premature aging J:194926
premature death J:194926
normal skeleton phenotype J:194926
Bub1btm2.1Jvd/Bub1b+
involves: 129S6/SvEvTac * C57BL/6 		abnormal chromosome number J:293084
abnormal mitosis J:293084
abnormal mitotic spindle assembly checkpoint J:293084
abnormal mitotic spindle morphology J:293084
aneuploidy J:293084
Bub1btm2.1Jvd/Bub1btm3.1Jvd
involves: 129S6/SvEvTac * C57BL/6 		embryonic lethality prior to tooth bud stage J:293084
Bub1btm3.1Jvd/Bub1b+
involves: 129S6/SvEvTac * C57BL/6 		abnormal chromosome number J:293084
abnormal mitosis J:293084
abnormal mitotic spindle assembly checkpoint J:293084
abnormal mitotic spindle morphology J:293084
aneuploidy J:293084
decreased tumor latency J:293084
increased tumor growth/size J:293084
normal mortality/aging J:293084
normal neoplasm J:293084
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory