About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lig4
ligase IV, DNA, ATP-dependent
MGI:1335098
94 phenotypes from 8 alleles in 11 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Lig4m1Btlr/Lig4m1Btlr
C57BL/6J-Lig4m1Btlr 		decreased B cell number J:267684
decreased CD4-positive, alpha-beta T cell number J:267684
decreased CD8-positive, naive alpha-beta T cell number J:267684
decreased IgD level J:267684
decreased IgG level J:267684
impaired humoral immune response J:267684
increased CD8-positive, alpha-beta T cell number J:267684
increased central memory CD8 positive, alpha-beta T cell number J:267684
increased effector memory CD4-positive, alpha-beta T cell number J:267684
increased NK cell number J:267684
Lig4m2Btlr/Lig4m2Btlr
C57BL/6J-Lig4m2Btlr 		decreased CD4-positive, alpha-beta T cell number J:267692
increased effector memory CD4-positive, alpha-beta T cell number J:267692
Lig4tiny/Lig4tiny
C57BL/6-Lig4tiny 		abnormal DNA repair J:122725
abnormal proerythroblast morphology J:122725
absent CD8-positive, alpha-beta T cells J:104190
decreased B cell number J:122725
decreased body size J:122725
decreased bone marrow cell number J:122725
decreased fibroblast proliferation J:122725
decreased hematopoietic stem cell number J:122725
decreased lymphocyte cell number J:122725
postnatal growth retardation J:122725
prenatal lethality, incomplete penetrance J:122725
Lig4tm1Fwa/Lig4+
involves: 129S6/SvEvTac * C57BL/6 		chromosome breakage J:80467
Lig4tm1Fwa/Lig4tm1Fwa
involves: 129S6/SvEvTac 		abnormal brainstem morphology J:110848
abnormal cell physiology J:110848
abnormal diencephalon morphology J:110848
abnormal striatum morphology J:110848
chromosomal instability J:147247
increased cellular sensitivity to ionizing radiation J:147247
increased forebrain apoptosis J:110848
increased spinal cord apoptosis J:110848
induced chromosome breakage J:147247
thin cerebral cortex J:110848
Lig4tm1Fwa/Lig4tm1Fwa
involves: 129S6/SvEvTac * C57BL/6 		abnormal B cell differentiation J:50865
abnormal cell physiology J:50865
abnormal lymphopoiesis J:50865
abnormal T cell differentiation J:63078
arrested B cell differentiation J:63078
arrested T cell differentiation J:50865
chromosome breakage J:80467
decreased cell proliferation J:50865
decreased fetal size J:50865
decreased thymocyte number J:63078
normal hematopoietic system phenotype J:50865
increased cellular sensitivity to gamma-irradiation J:50865
lethality throughout fetal growth and development, incomplete penetrance J:50865
prenatal lethality, complete penetrance J:80467
small thymus J:50865
Lig4tm1Icrf/Lig4tm1Icrf
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		increased neuron apoptosis J:51608, J:65540, J:111068
lethality throughout fetal growth and development, complete penetrance J:51608
Lig4tm1Icrf/Lig4tm1Icrf
involves: 129 		normal cellular phenotype J:144172
Lig4tm1Pmc/Lig4tm1Pmc
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor 		abnormal nervous system development J:144617
Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * C57BL/6 * SJL 		abnormal double-strand DNA break repair J:226703
normal nervous system phenotype J:144617
Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * C57BL/6 * SJL 		abnormal brain development J:144172
abnormal DNA repair J:144172
ataxia J:144172
decreased brain size J:144172
decreased brain weight J:144172
microcephaly J:144172
Lig4tm2.1Fwa/Lig4tm2.1Fwa
involves: 129S6/SvEvTac 		abnormal B cell activation J:157574
abnormal B cell differentiation J:157574
abnormal cell physiology J:157574
abnormal immune system cell morphology J:157574
abnormal immune system morphology J:157574
abnormal immune system organ morphology J:157574
abnormal immune system physiology J:157574
abnormal lymphocyte cell number J:157574
abnormal regulatory T cell morphology J:157574
abnormal T cell activation J:157574
abnormal T cell differentiation J:157574
abnormal T cell receptor beta chain V(D)J recombination J:157574
abnormal T cell receptor V(D)J recombination J:157574
abnormal thymus morphology J:157574
chromosomal instability J:157574
decreased B cell number J:157574
decreased body size J:157574
decreased body weight J:157574
decreased CD4-positive, alpha-beta T cell number J:157574
decreased CD8-positive, alpha-beta T cell number J:157574
decreased double-negative T cell number J:157574
decreased double-positive T cell number J:157574
decreased IgA level J:157574
decreased IgG2b level J:157574
decreased IgG3 level J:157574
decreased IgG level J:157574
decreased IgM level J:157574
decreased immunoglobulin level J:157574
decreased interferon-gamma secretion J:157574
decreased interleukin-13 secretion J:157574
decreased spleen weight J:157574
decreased splenocyte number J:157574
decreased T cell proliferation J:157574
decreased thymocyte number J:157574
decreased thymus weight J:157574
increased anti-chromatin antibody level J:157574
increased anti-double stranded DNA antibody level J:157574
increased cellular sensitivity to gamma-irradiation J:157574
increased colon adenocarcinoma incidence J:157574
increased medulloblastoma incidence J:157574
increased T cell apoptosis J:157574
increased T cell derived lymphoma incidence J:157574
intestinal inflammation J:157574
liver inflammation J:157574
postnatal growth retardation J:157574
premature death J:157574
reduced fertility J:157574
small spleen J:157574
small thymus J:157574
spontaneous chromosome breakage J:157574
Lig4tm3.1Fwa/Lig4tm3.1Fwa
Tg(Cr2-cre)3Cgn/0
Not Specified 		abnormal class switch recombination J:157537
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory