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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lig4
ligase IV, DNA, ATP-dependent
MGI:1335098
94 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lig4m1Btlr/Lig4m1Btlr
C57BL/6J-Lig4m1Btlr 		decreased B cell number J:267684
decreased CD4-positive, alpha-beta T cell number J:267684
decreased CD8-positive, naive alpha-beta T cell number J:267684
decreased IgD level J:267684
decreased IgG level J:267684
impaired humoral immune response J:267684
increased CD8-positive, alpha-beta T cell number J:267684
increased central memory CD8 positive, alpha-beta T cell number J:267684
increased effector memory CD4-positive, alpha-beta T cell number J:267684
increased NK cell number J:267684
Lig4m2Btlr/Lig4m2Btlr
C57BL/6J-Lig4m2Btlr 		decreased CD4-positive, alpha-beta T cell number J:267692
increased effector memory CD4-positive, alpha-beta T cell number J:267692
Lig4tiny/Lig4tiny
C57BL/6-Lig4tiny 		abnormal DNA repair J:122725
abnormal proerythroblast morphology J:122725
absent CD8-positive, alpha-beta T cells J:104190
decreased B cell number J:122725
decreased body size J:122725
decreased bone marrow cell number J:122725
decreased fibroblast proliferation J:122725
decreased hematopoietic stem cell number J:122725
decreased lymphocyte cell number J:122725
postnatal growth retardation J:122725
prenatal lethality, incomplete penetrance J:122725
Lig4tm1Fwa/Lig4+
involves: 129S6/SvEvTac * C57BL/6 		chromosome breakage J:80467
Lig4tm1Fwa/Lig4tm1Fwa
involves: 129S6/SvEvTac 		abnormal brainstem morphology J:110848
abnormal cell physiology J:110848
abnormal diencephalon morphology J:110848
abnormal striatum morphology J:110848
chromosomal instability J:147247
increased cellular sensitivity to ionizing radiation J:147247
increased forebrain apoptosis J:110848
increased spinal cord apoptosis J:110848
induced chromosome breakage J:147247
thin cerebral cortex J:110848
Lig4tm1Fwa/Lig4tm1Fwa
involves: 129S6/SvEvTac * C57BL/6 		abnormal B cell differentiation J:50865
abnormal cell physiology J:50865
abnormal lymphopoiesis J:50865
abnormal T cell differentiation J:63078
arrested B cell differentiation J:63078
arrested T cell differentiation J:50865
chromosome breakage J:80467
decreased cell proliferation J:50865
decreased fetal size J:50865
decreased thymocyte number J:63078
normal hematopoietic system phenotype J:50865
increased cellular sensitivity to gamma-irradiation J:50865
lethality throughout fetal growth and development, incomplete penetrance J:50865
prenatal lethality, complete penetrance J:80467
small thymus J:50865
Lig4tm1Icrf/Lig4tm1Icrf
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		increased neuron apoptosis J:51608, J:65540, J:111068
lethality throughout fetal growth and development, complete penetrance J:51608
Lig4tm1Icrf/Lig4tm1Icrf
involves: 129 		normal cellular phenotype J:144172
Lig4tm1Pmc/Lig4tm1Pmc
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor 		abnormal nervous system development J:144617
Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * C57BL/6 * SJL 		abnormal double-strand DNA break repair J:226703
normal nervous system phenotype J:144617
Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * C57BL/6 * SJL 		abnormal brain development J:144172
abnormal DNA repair J:144172
ataxia J:144172
decreased brain size J:144172
decreased brain weight J:144172
microcephaly J:144172
Lig4tm2.1Fwa/Lig4tm2.1Fwa
involves: 129S6/SvEvTac 		abnormal B cell activation J:157574
abnormal B cell differentiation J:157574
abnormal cell physiology J:157574
abnormal immune system cell morphology J:157574
abnormal immune system morphology J:157574
abnormal immune system organ morphology J:157574
abnormal immune system physiology J:157574
abnormal lymphocyte cell number J:157574
abnormal regulatory T cell morphology J:157574
abnormal T cell activation J:157574
abnormal T cell differentiation J:157574
abnormal T cell receptor beta chain V(D)J recombination J:157574
abnormal T cell receptor V(D)J recombination J:157574
abnormal thymus morphology J:157574
chromosomal instability J:157574
decreased B cell number J:157574
decreased body size J:157574
decreased body weight J:157574
decreased CD4-positive, alpha-beta T cell number J:157574
decreased CD8-positive, alpha-beta T cell number J:157574
decreased double-negative T cell number J:157574
decreased double-positive T cell number J:157574
decreased IgA level J:157574
decreased IgG2b level J:157574
decreased IgG3 level J:157574
decreased IgG level J:157574
decreased IgM level J:157574
decreased immunoglobulin level J:157574
decreased interferon-gamma secretion J:157574
decreased interleukin-13 secretion J:157574
decreased spleen weight J:157574
decreased splenocyte number J:157574
decreased T cell proliferation J:157574
decreased thymocyte number J:157574
decreased thymus weight J:157574
increased anti-chromatin antibody level J:157574
increased anti-double stranded DNA antibody level J:157574
increased cellular sensitivity to gamma-irradiation J:157574
increased colon adenocarcinoma incidence J:157574
increased medulloblastoma incidence J:157574
increased T cell apoptosis J:157574
increased T cell derived lymphoma incidence J:157574
intestinal inflammation J:157574
liver inflammation J:157574
postnatal growth retardation J:157574
premature death J:157574
reduced fertility J:157574
small spleen J:157574
small thymus J:157574
spontaneous chromosome breakage J:157574
Lig4tm3.1Fwa/Lig4tm3.1Fwa
Tg(Cr2-cre)3Cgn/0
Not Specified 		abnormal class switch recombination J:157537
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory