About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lig4
ligase IV, DNA, ATP-dependent
MGI:1335098
34 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Atmtm1Pmc/Atm+
Lig4tm1Icrf/Lig4tm1Icrf
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		increased neuron apoptosis J:65540
Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Icrf/Lig4+
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		increased neuron apoptosis J:65540
Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Icrf/Lig4tm1Icrf
either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ) 		decreased body size J:65540
decreased neuron apoptosis J:65540, J:111068
neonatal lethality, complete penetrance J:65540, J:111068
Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Icrf/Lig4tm1Icrf
involves: 129 		decreased cellular sensitivity to ionizing radiation J:144172
perinatal lethality J:144172
Atmtm1Pmc/Atmtm1Pmc
Lig4tm1Pmc/Lig4tm1Pmc
Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * C57BL/6 * SJL 		ataxia J:144172
normal nervous system phenotype J:144172
Cdkn2atm1Rdp/Cdkn2a+
Lig4tm1Fwa/Lig4tm1Fwa
involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL 		decreased cell proliferation J:63078
increased cellular sensitivity to ionizing radiation J:63078
increased neuron apoptosis J:63078
prenatal lethality, complete penetrance J:63078
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Lig4tm1Fwa/Lig4tm1Fwa
involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL 		decreased cell proliferation J:63078
prenatal lethality, complete penetrance J:63078
Ightm2Cgn/Ightm2Cgn
Igktm1Rsky/Igktm1Rsky
Lig4tm1Fwa/Lig4tm1Fwa
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac 		abnormal class switch recombination J:126758
Lig4tm1Fwa/Lig4tm1Fwa
Tg(Cr2-cre)3Cgn/0
Xrcc4tm2Fwa/Xrcc4tm2Fwa
involves: 129S6/SvEvTac 		abnormal class switch recombination J:126758
increased cellular sensitivity to ionizing radiation J:126758
spontaneous chromosome breakage J:126758
Lig4tm1Fwa/Lig4tm1Fwa
Trp53tm1Brd/Trp53+
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		decreased body weight J:63078
decreased neuron apoptosis J:63078
premature death J:63078
prenatal lethality, incomplete penetrance J:63078
Lig4tm1Fwa/Lig4tm1Fwa
Trp53tm1Brd/Trp53tm1Brd
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		decreased body weight J:63078
decreased neuron apoptosis J:63078
decreased thymocyte number J:63078
increased B cell number J:63078
increased cellular sensitivity to ionizing radiation J:63078
increased fibroblast proliferation J:63078
increased lymphoma incidence J:63078
premature death J:63078
prenatal lethality, incomplete penetrance J:63078
Lig4tm1Icrf/Lig4tm1Icrf
Mre11atm1Jpt/Mre11atm1Jpt
involves: 129 * 129S7/SvEvBrd 		decreased cellular sensitivity to ionizing radiation J:144172
neonatal lethality, complete penetrance J:144172
Lig4tm1Icrf/Lig4tm1Icrf
Nbntm1Jpt/Nbntm1Jpt
involves: 129 * 129S7/SvEvBrd 		normal cellular phenotype J:144172
prenatal lethality, complete penetrance J:144172
Lig4tm1Icrf/Lig4tm1Icrf
Nbntm2.1Jpt/Nbntm2.1Jpt
involves: 129 		perinatal lethality, complete penetrance J:144172
Lig4tm1Icrf/Lig4tm1Icrf
Trp53tm1Tyj/Trp53+
either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ) 		decreased tumor incidence J:111068
perinatal lethality, incomplete penetrance J:111068
premature death J:111068
Lig4tm1Icrf/Lig4tm1Icrf
Trp53tm1Tyj/Trp53tm1Tyj
either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ) 		increased B cell derived lymphoma incidence J:111068
increased medulloblastoma incidence J:111068
Lig4tm1Pmc/Lig4tm1Pmc
Mre11atm1Jpt/Mre11atm1Jpt
Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL 		ataxia J:144172
normal nervous system phenotype J:144172
Lig4tm1Pmc/Lig4tm1Pmc
Nbntm1Jpt/Nbntm1Jpt
Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal brain development J:144172
decreased brain weight J:144172
microcephaly J:144172
Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53+
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		abnormal tumor morphology J:144617
increased medulloblastoma incidence J:144617
premature death J:144617
Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
premature death J:144617
Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
premature death J:144617
Paxxem1Spj/Paxxem1Spj
Lig4tm1Fwa/Lig4tm1Fwa
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac 		prenatal lethality, complete penetrance J:236776
Xrcc5tm1Dbr/Xrcc5+
Lig4tm1Fwa/Lig4+
involves: 129S6/SvEvTac * C57BL/6 		chromosome breakage J:80467
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Lig4tm1Fwa/Lig4tm1Fwa
involves: 129S6/SvEvTac * C57BL/6 		abnormal lymphocyte morphology J:80467
abnormal small intestine morphology J:80467
chromosome breakage J:80467
normal mortality/aging J:80467
prenatal lethality, incomplete penetrance J:80467
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory