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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pikfyve
phosphoinositide kinase, FYVE type zinc finger containing
MGI:1335106
94 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lyz2tm1(cre)Ifo/Lyz2+
Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu
involves: 129P2/OlaHsd * C57BL/6N 		abnormal alveolar macrophage morphology J:244776
abnormal alveolar macrophage physiology J:244776
decreased alveolar macrophage number J:244776
decreased regulatory T cell number J:244776
normal immune system phenotype J:244776
increased eosinophil cell number J:244776
increased interleukin-4 secretion J:244776
increased interleukin-13 secretion J:244776
increased susceptibility to type I hypersensitivity reaction J:244776
PikfyveGt(AT0926)Wtsi/PikfyveGt(AT0926)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		abnormal atrium myocardium morphology J:190368
abnormal brain morphology J:190368
abnormal brainstem morphology J:190368
abnormal cerebellum deep nucleus morphology J:190368
abnormal dorsal root ganglion morphology J:190368
abnormal embryonic/fetal subventricular zone morphology J:190368
abnormal heart morphology J:190368
abnormal lipid level J:190368
abnormal locomotor behavior J:190368
abnormal midbrain morphology J:190368
abnormal neuron morphology J:190368
abnormal pons morphology J:190368
abnormal pulmonary alveolar system morphology J:190368
abnormal renal tubule morphology J:190368
abnormal spinal cord morphology J:190368
abnormal spleen morphology J:190368
abnormal superior vena cava morphology J:190368
abnormal thymus morphology J:190368
abnormal ventricle myocardium morphology J:190368
brain vacuoles J:190368
decreased birth body size J:190368
decreased body weight J:190368
decreased brain weight J:190368
dilated heart right ventricle J:190368
increased heart right atrium size J:190368
kidney degeneration J:190368
perinatal lethality, incomplete penetrance J:190368
postnatal lethality, complete penetrance J:190368
pulmonary vascular congestion J:190368
small heart J:190368
spleen hypoplasia J:190368
thymus hypoplasia J:190368
Pikfyvetm1.1Ashi/Pikfyvetm1.1Ashi
involves: C57BL/6 		decreased DNA replication J:171129
Pikfyvetm1.1Ashi/Pikfyvetm1.1Ashi
involves: C57BL/6 		no abnormal phenotype detected J:199213
Pikfyvetm1.1Ashi/Pikfyvetm1.1Ashi
Tg(Ckm-cre)28Arte/0
involves: C57BL/6 		decreased heart weight J:199213
decreased muscle cell glucose uptake J:199213
normal homeostasis/metabolism phenotype J:199213
impaired glucose tolerance J:199213
increased adipocyte glucose uptake J:199213
increased body weight J:199213
increased circulating insulin level J:199213
increased circulating triglyceride level J:199213
increased fat cell size J:199213
increased gonadal fat pad weight J:199213
increased renal fat pad weight J:199213
increased susceptibility to age related obesity J:199213
increased total body fat amount J:199213
insulin resistance J:199213
normal muscle phenotype J:199213
Pikfyvetm1.2Ashi/Pikfyve+
involves: C57BL/6 		abnormal cell morphology J:171129
Pikfyvetm1.2Ashi/Pikfyvetm1.2Ashi
involves: C57BL/6 		abnormal blastocoele morphology J:171129
abnormal blastocyst morphology J:171129
abnormal inner cell mass morphology J:171129
abnormal trophectoderm morphology J:171129
absent blastocoele J:171129
embryonic lethality before implantation, complete penetrance J:171129
embryonic lethality before implantation, incomplete penetrance J:171129
Pikfyvetm1Tssk/Pikfyvetm1Tssk
involves: 129P2/OlaHsd * C57BL/6 		abnormal visceral endoderm morphology J:193689
abnormal visceral endoderm physiology J:193689
decreased embryo size J:193689
embryonic growth arrest J:193689
embryonic lethality between somite formation and embryo turning, complete penetrance J:193689
Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk
Tg(Tyr-cre/ERT2)13Bos/0
involves: C57BL/6 * C57BL/6J 		abnormal coat/hair pigmentation J:262141
abnormal endosome to melanosome transport J:262141
abnormal hair follicle melanocyte morphology J:262141
abnormal melanosome maturation J:262141
diluted coat color J:262141
reduced hair shaft melanin granule number J:262141
Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk
Tg(Vil1-cre)20Syr/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal circulating enzyme level J:193689
abnormal enterocyte morphology J:193689
abnormal small intestinal microvillus morphology J:193689
decreased body weight J:193689
decreased circulating free fatty acids level J:193689
decreased circulating serum albumin level J:193689
decreased circulating total protein level J:193689
decreased small intestinal microvillus size J:193689
diarrhea J:193689
disheveled coat J:193689
hunched posture J:193689
intestinal fibrosis J:193689
intestinal inflammation J:193689
lethality, incomplete penetrance J:193689
lethargy J:193689
melena J:193689
premature death J:193689
prenatal lethality, incomplete penetrance J:193689
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12/10/2024
MGI 6.24 		The Jackson Laboratory