Cflar Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cflar
CASP8 and FADD-like apoptosis regulator
MGI:1336166

39 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cflar^tm1.1Pope/Cflar^tm1.2Pope Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd	abnormal abdominal lymph node morphology	J:167430
	abnormal B cell number	J:167430
	abnormal bone marrow cell number	J:167430
	abnormal CD4-positive, alpha-beta T cell number	J:167430
	abnormal CD8-positive, alpha-beta T cell number	J:167430
	abnormal definitive hematopoiesis	J:167430
	abnormal erythropoiesis	J:167430
	abnormal lymphocyte cell number	J:167430
	abnormal myelopoiesis	J:167430
	abnormal spleen B cell follicle morphology	J:167430
	abnormal spleen marginal zone morphology	J:167430
	abnormal spleen morphology	J:167430
	abnormal spleen red pulp morphology	J:167430
	abnormal thymus corticomedullary boundary morphology	J:167430
	abnormal thymus morphology	J:167430
	anemia	J:167430
	decreased body size	J:167430
	decreased macrophage cell number	J:167430
	enlarged spleen	J:167430
	increased CD8-positive, alpha-beta T cell number	J:167430
	increased eosinophil cell number	J:167430
	increased granulocyte number	J:167430
	increased leukocyte cell number	J:167430
	increased monocyte cell number	J:167430
	increased neutrophil cell number	J:167430
	premature death	J:167430
	thrombocytosis	J:167430
Cflar^{tm1b(EUCOMM)Wtsi}/Cflar^{tm1b(EUCOMM)Wtsi} C57BL/6N-Cflar^{tm1b(EUCOMM)Wtsi}/Orl	preweaning lethality, complete penetrance	J:211773
Cflar^tm1Mak/Cflar^tm1Mak either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	abnormal myocardial trabeculae morphology	J:63049
	delayed heart development	J:63049
	distended pericardium	J:63049
	embryonic growth retardation	J:63049
	embryonic lethality during organogenesis, complete penetrance	J:63049
	hemorrhage	J:63049
	increased fibroblast apoptosis	J:63049
	pericardial edema	J:63049
	thin myocardium	J:63049
Cflar^tm1Ywh/Cflar^tm1Ywh Tg(Lck-cre)548Jxm/0 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA	decreased single-positive T cell number	J:100558
	increased thymocyte apoptosis	J:100558

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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