Prkab1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
MGI:1336167

126 phenotypes from 7 alleles in 17 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prkab1^em1(IMPC)Bay/Prkab1^em1(IMPC)Bay C57BL/6N-Prkab1^em1(IMPC)Bay/Bay	increased spleen weight	J:211773
Prkab1^em1(IMPC)J/Prkab1^em1(IMPC)J C57BL/6NJ-Prkab1^em1(IMPC)J/J	decreased fasting circulating glucose level	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular volume	J:211773
	impaired glucose tolerance	J:211773
Prkab1^em2(IMPC)Mbp/Prkab1^em2(IMPC)Mbp C57BL/6N-Prkab1^em2(IMPC)Mbp/Ucd	abnormal heart morphology	J:211773
	abnormal thymus morphology	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular volume	J:211773
	enlarged heart	J:211773
	enlarged thymus	J:211773
	increased red blood cell distribution width	J:211773
Prkab1^{Gt(RRR454)Byg}/Prkab1^{Gt(RRR454)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal astrocyte morphology	J:146618
	abnormal axon morphology	J:146618
	abnormal cerebellum morphology	J:146618
	abnormal cerebral cortex morphology	J:146618
	abnormal dendrite morphology	J:146618
	abnormal dentate gyrus morphology	J:146618
	abnormal myelination	J:146618
	abnormal neuron differentiation	J:146618
	abnormal neuronal precursor proliferation	J:146618
	abnormal optic nerve morphology	J:146618
	absent cerebellar granule layer	J:146618
	astrocytosis	J:146618
	ataxia	J:146618
	brain vacuoles	J:146618
	cerebellum atrophy	J:146618
	decreased body weight	J:146618
	decreased brain size	J:146618
	decreased cerebellar granule cell number	J:146618
	decreased neuron number	J:146618
	decreased oligodendrocyte number	J:146618
	loss of hippocampal neurons	J:146618
	optic nerve hypoplasia	J:146618
	postnatal lethality, complete penetrance	J:146618
	seizures	J:146618
	slow postnatal weight gain	J:146618
	tremors	J:146618
Prkab1^{tm1a(KOMP)Wtsi}/Prkab1^{tm1a(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1a(KOMP)Wtsi}/Wtsi	abnormal ductus venosus morphology	J:239583
	abnormal inferior vena cava morphology	J:239583
	decreased circulating magnesium level	J:175295
	decreased erythrocyte cell number	J:175295
	decreased hematocrit	J:175295
	decreased hemoglobin content	J:175295
	decreased mean corpuscular hemoglobin	J:175295
	increased circulating bilirubin level	J:175295
	no abnormal phenotype detected	J:239583
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1⁺ C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Ccpcz	abnormal testis morphology	J:211773
	decreased Ly6C-positive mature NK cell number	J:211773
	decreased lymphocyte cell number	J:211773
	enlarged testis	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1⁺ C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Ieg	abnormal lens morphology	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	cataract	J:211773
	decreased circulating phosphate level	J:211773
	decreased total retina thickness	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} B6N(Cg)-Prkab1^{tm1b(KOMP)Wtsi}/J	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased erythrocyte cell number	J:211773
	decreased hematocrit	J:211773
	decreased hemoglobin content	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	decreased mean corpuscular volume	J:211773
	increased circulating bilirubin level	J:211773
	increased heart weight	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Bay	abnormal retina inner nuclear layer morphology	J:211773
	decreased total retina thickness	J:211773
	enlarged heart	J:211773
	increased spleen weight	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Ccpcz	abnormal heart left ventricle morphology	J:211773
	abnormal spleen morphology	J:211773
	decreased body weight	J:211773
	decreased circulating chloride level	J:211773
	decreased hematocrit	J:211773
	decreased hemoglobin content	J:211773
	decreased kidney weight	J:211773
	decreased lung elastance	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	decreased mean corpuscular volume	J:211773
	enlarged spleen	J:211773
	increased circulating alanine transaminase level	J:211773
	increased fasting circulating glucose level	J:211773
	increased heart rate	J:211773
	increased lung compliance	J:211773
	increased red blood cell distribution width	J:211773
	increased spleen weight	J:211773
	no spontaneous movement	J:211773
	shortened RR interval	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/H	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased circulating iron level	J:211773
	decreased hematocrit	J:211773
	decreased hemoglobin content	J:211773
	decreased lymphocyte cell number	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	decreased mean corpuscular volume	J:211773
	impaired glucose tolerance	J:211773
	increased fasting circulating glucose level	J:211773
	increased neutrophil cell number	J:211773
	increased red blood cell distribution width	J:211773
	increased spleen weight	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Ieg	abnormal lens morphology	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/MbpMmucd	abnormal freezing behavior	J:211773
	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased hematocrit	J:211773
	decreased hemoglobin content	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular volume	J:211773
	impaired contextual conditioning behavior	J:211773
	impaired glucose tolerance	J:211773
	increased red blood cell distribution width	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Orl	anophthalmia	J:211773
	decreased grip strength	J:211773
	decreased hemoglobin content	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	decreased mean corpuscular volume	J:211773
	decreased total retina thickness	J:211773
	increased heart weight	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Rbrc	decreased bone mineral content	J:211773
	decreased bone mineral density	J:211773
	decreased circulating amylase level	J:211773
	decreased hematocrit	J:211773
	decreased hemoglobin content	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	decreased mean corpuscular volume	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating bilirubin level	J:211773
	increased glycosylated hemoglobin level	J:211773
	increased red blood cell distribution width	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Ucd	abnormal epididymis morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal spleen morphology	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular volume	J:211773
	enlarged epididymis	J:211773
	enlarged kidney	J:211773
	enlarged spleen	J:211773
	increased red blood cell distribution width	J:211773
	increased spleen weight	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Wtsi	absent pinna reflex	J:211773
	decreased circulating cholesterol level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased circulating LDL cholesterol level	J:211773
	decreased hematocrit	J:211773
	decreased hemoglobin content	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	increased circulating bilirubin level	J:211773
	increased mean platelet volume	J:211773
	increased memory-marker CD4-negative NK T cell number	J:211773
	increased memory-marker gamma-delta T cell number	J:211773
	increased red blood cell distribution width	J:211773
Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} involves: C57BL/6N	abnormal bone marrow morphology	J:236972
	abnormal erythrocyte morphology	J:236972
	abnormal erythropoiesis	J:236972
	abnormal reticulocyte cell number	J:236972
	acanthocytosis	J:236972
	anisocytosis	J:236972
	decreased circulating iron level	J:236972
	decreased erythrocyte cell number	J:236972
	decreased erythrocyte osmotic fragility	J:236972
	decreased hematocrit	J:236972
	decreased hemoglobin content	J:236972
	decreased mean corpuscular hemoglobin concentration	J:236972
	echinocytosis	J:236972
	enlarged spleen	J:236972
	extramedullary hematopoiesis	J:236972
	hemolytic anemia	J:236972
	increased circulating erythropoietin level	J:236972
	increased circulating ferritin level	J:236972
	increased erythroblast number	J:236972
	increased erythroid progenitor cell number	J:236972
	increased mean platelet volume	J:236972
	increased red blood cell distribution width	J:236972
	increased spleen iron level	J:236972
	increased spleen red pulp amount	J:236972
	increased spleen weight	J:236972
	microcytic anemia	J:236972
	microcytosis	J:236972
	reticulocytosis	J:236972
	schistocytosis	J:236972
	stomatocytosis	J:236972
Prkab1^tm1Eihl/Prkab1^tm1Eihl involves: C57BL/6	abnormal hepatocyte physiology	J:158295
	abnormal lipid level	J:158295
	decreased body weight	J:158295
	decreased circulating insulin level	J:158295
	decreased circulating interleukin-6 level	J:158295
	decreased circulating leptin level	J:158295
	decreased epididymal fat pad weight	J:158295
	decreased food intake	J:158295
	decreased liver triglyceride level	J:158295
	decreased susceptibility to diet-induced hepatic steatosis	J:158295
	decreased susceptibility to diet-induced obesity	J:158295
	normal homeostasis/metabolism phenotype	J:158295, J:204961
	increased insulin sensitivity	J:158295
	normal renal/urinary system phenotype	J:204961

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