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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
MGI:1336167
123 phenotypes from 7 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prkab1em1(IMPC)Bay/Prkab1em1(IMPC)Bay
C57BL/6N-Prkab1em1(IMPC)Bay/Bay 		increased spleen weight J:211773
Prkab1em1(IMPC)J/Prkab1em1(IMPC)J
C57BL/6NJ-Prkab1em1(IMPC)J/J 		decreased fasting circulating glucose level J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular volume J:211773
impaired glucose tolerance J:211773
Prkab1em2(IMPC)Mbp/Prkab1em2(IMPC)Mbp
C57BL/6N-Prkab1em2(IMPC)Mbp/Ucd 		abnormal thymus morphology J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular volume J:211773
enlarged thymus J:211773
increased red blood cell distribution width J:211773
Prkab1Gt(RRR454)Byg/Prkab1Gt(RRR454)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal astrocyte morphology J:146618
abnormal axon morphology J:146618
abnormal cerebellum morphology J:146618
abnormal cerebral cortex morphology J:146618
abnormal dendrite morphology J:146618
abnormal dentate gyrus morphology J:146618
abnormal myelination J:146618
abnormal neuron differentiation J:146618
abnormal neuronal precursor proliferation J:146618
abnormal optic nerve morphology J:146618
absent cerebellar granule layer J:146618
astrocytosis J:146618
ataxia J:146618
brain vacuoles J:146618
cerebellum atrophy J:146618
decreased body weight J:146618
decreased brain size J:146618
decreased cerebellar granule cell number J:146618
decreased neuron number J:146618
decreased oligodendrocyte number J:146618
loss of hippocampal neurons J:146618
optic nerve hypoplasia J:146618
postnatal lethality, complete penetrance J:146618
seizures J:146618
slow postnatal weight gain J:146618
tremors J:146618
Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi 		abnormal ductus venosus morphology J:239583
abnormal inferior vena cava morphology J:239583
decreased circulating magnesium level J:175295
decreased erythrocyte cell number J:175295
decreased hematocrit J:175295
decreased hemoglobin content J:175295
decreased mean corpuscular hemoglobin J:175295
increased circulating bilirubin level J:175295
no abnormal phenotype detected J:239583
Prkab1tm1b(KOMP)Wtsi/Prkab1+
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Ccpcz 		abnormal testis morphology J:211773
decreased Ly6C-positive mature NK cell number J:211773
decreased lymphocyte cell number J:211773
enlarged testis J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1+
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Ieg 		abnormal lens morphology J:211773
abnormal retina blood vessel morphology J:211773
abnormal retina vasculature morphology J:211773
cataract J:211773
decreased circulating phosphate level J:211773
decreased total retina thickness J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
B6N(Cg)-Prkab1tm1b(KOMP)Wtsi/J 		decreased circulating cholesterol level J:211773
decreased circulating HDL cholesterol level J:211773
decreased erythrocyte cell number J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased mean corpuscular volume J:211773
increased circulating bilirubin level J:211773
increased heart weight J:211773
preweaning lethality, incomplete penetrance J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Bay 		abnormal retina inner nuclear layer morphology J:211773
decreased total retina thickness J:211773
enlarged heart J:211773
increased spleen weight J:211773
preweaning lethality, incomplete penetrance J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Ccpcz 		abnormal spleen morphology J:211773
decreased body weight J:211773
decreased circulating chloride level J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased lung elastance J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular volume J:211773
enlarged spleen J:211773
increased circulating alanine transaminase level J:211773
increased fasting circulating glucose level J:211773
increased heart rate J:211773
increased lung compliance J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
no spontaneous movement J:211773
shortened RR interval J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/H 		decreased circulating cholesterol level J:211773
decreased circulating HDL cholesterol level J:211773
decreased circulating iron level J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased lymphocyte cell number J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased mean corpuscular volume J:211773
impaired glucose tolerance J:211773
increased fasting circulating glucose level J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Ieg 		abnormal lens morphology J:211773
preweaning lethality, incomplete penetrance J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/MbpMmucd 		abnormal freezing behavior J:211773
decreased circulating cholesterol level J:211773
decreased circulating HDL cholesterol level J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular volume J:211773
impaired contextual conditioning behavior J:211773
impaired glucose tolerance J:211773
increased red blood cell distribution width J:211773
preweaning lethality, incomplete penetrance J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Orl 		anophthalmia J:211773
decreased grip strength J:211773
decreased hemoglobin content J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased mean corpuscular volume J:211773
decreased total retina thickness J:211773
increased heart weight J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Rbrc 		decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased circulating amylase level J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased mean corpuscular volume J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating bilirubin level J:211773
increased glycosylated hemoglobin level J:211773
increased red blood cell distribution width J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Ucd 		abnormal epididymis morphology J:211773
abnormal kidney morphology J:211773
abnormal spleen morphology J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular volume J:211773
enlarged epididymis J:211773
enlarged kidney J:211773
enlarged spleen J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
preweaning lethality, incomplete penetrance J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Wtsi 		absent pinna reflex J:211773
decreased circulating cholesterol level J:211773
decreased circulating HDL cholesterol level J:211773
decreased circulating LDL cholesterol level J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased mean corpuscular hemoglobin J:211773
increased circulating bilirubin level J:211773
increased mean platelet volume J:211773
increased memory-marker CD4-negative NK T cell number J:211773
increased memory-marker gamma-delta T cell number J:211773
increased red blood cell distribution width J:211773
Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
involves: C57BL/6N 		abnormal bone marrow morphology J:236972
abnormal erythrocyte morphology J:236972
abnormal erythropoiesis J:236972
abnormal reticulocyte cell number J:236972
acanthocytosis J:236972
anisocytosis J:236972
decreased circulating iron level J:236972
decreased erythrocyte cell number J:236972
decreased erythrocyte osmotic fragility J:236972
decreased hematocrit J:236972
decreased hemoglobin content J:236972
decreased mean corpuscular hemoglobin concentration J:236972
echinocytosis J:236972
enlarged spleen J:236972
extramedullary hematopoiesis J:236972
hemolytic anemia J:236972
increased circulating erythropoietin level J:236972
increased circulating ferritin level J:236972
increased erythroblast number J:236972
increased erythroid progenitor cell number J:236972
increased mean platelet volume J:236972
increased red blood cell distribution width J:236972
increased spleen iron level J:236972
increased spleen red pulp amount J:236972
increased spleen weight J:236972
microcytic anemia J:236972
microcytosis J:236972
reticulocytosis J:236972
schistocytosis J:236972
stomatocytosis J:236972
Prkab1tm1Eihl/Prkab1tm1Eihl
involves: C57BL/6 		abnormal hepatocyte physiology J:158295
abnormal lipid level J:158295
decreased body weight J:158295
decreased circulating insulin level J:158295
decreased circulating interleukin-6 level J:158295
decreased circulating leptin level J:158295
decreased epididymal fat pad weight J:158295
decreased food intake J:158295
decreased liver triglyceride level J:158295
decreased susceptibility to diet-induced hepatic steatosis J:158295
decreased susceptibility to diet-induced obesity J:158295
normal homeostasis/metabolism phenotype J:158295, J:204961
increased insulin sensitivity J:158295
normal renal/urinary system phenotype J:204961
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory