Prkaa2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
MGI:1336173

42 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prkaa2^tm1.1Sjm/Prkaa2^tm1.1Sjm Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * SJL	pulmonary hypertension	J:286356
Prkaa2^tm1.1Vio/Prkaa2^tm1.1Vio involves: 129S2/SvPas	decreased circulating insulin level	J:87719
	decreased skeletal muscle cell glucose uptake	J:87719
	decreased skeletal muscle glycogen level	J:87719
	impaired glucose tolerance	J:87719
	increased skeletal muscle cell glucose uptake	J:87719
Prkaa2^tm1.1Vio/Prkaa2^tm1.1Vio involves: 129S2/SvPas * C57BL/6	abnormal glucose homeostasis	J:81120
	abnormal glycogen homeostasis	J:81120
	abnormal sympathetic nervous system physiology	J:81120
	abnormal urine catecholamine level	J:81120
	decreased circulating insulin level	J:81120
	decreased circulating leptin level	J:81120
	decreased insulin secretion	J:81120
	decreased skeletal muscle glycogen level	J:81120
	normal homeostasis/metabolism phenotype	J:81120
	hyperglycemia	J:81120
	impaired glucose tolerance	J:81120
	increased circulating free fatty acids level	J:81120
	insulin resistance	J:81120
Prkaa2^{tm1b(EUCOMM)Hmgu}/Prkaa2^{tm1b(EUCOMM)Hmgu} C57BL/6N-Prkaa2^{tm1b(EUCOMM)Hmgu}/H	decreased circulating alkaline phosphatase level	J:211773
	decreased circulating fructosamine level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased exploration in new environment	J:211773
	decreased fasting circulating glucose level	J:211773
	decreased mean platelet volume	J:211773
	enlarged spleen	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased circulating creatine kinase level	J:211773
Prkaa2^tm1Vio/Prkaa2^tm1Vio Tg(Agrp-cre)1Gsb/0 involves: 129S2/SvPas * FVB/N	abnormal neuron physiology	J:123951
	decreased body weight	J:123951
	enhanced behavioral response to xenobiotic	J:123951
	normal homeostasis/metabolism phenotype	J:123951
Prkaa2^tm1Vio/Prkaa2^tm1Vio Tg(Alb1-cre)7Gsc/0 involves: 129S2/SvPas * FVB/N	abnormal gluconeogenesis	J:108399
	abnormal glucose homeostasis	J:108399
	impaired glucose tolerance	J:108399
	increased circulating adiponectin level	J:108399
	increased circulating glucose level	J:108399
	increased circulating insulin level	J:108399
	increased circulating leptin level	J:108399
	increased fatty acids level	J:108399
	increased triglyceride level	J:108399
Prkaa2^tm1Vio/Prkaa2^tm1Vio Tg(Pomc1-cre)1Gsb/0 involves: 129S2/SvPas * FVB/N	abnormal metabolism	J:123951
	abnormal neuron physiology	J:123951
	increased body weight	J:123951
	increased compensatory feeding amount	J:123951
	increased percent body fat/body weight	J:123951
	increased susceptibility to diet-induced obesity	J:123951
	normal nervous system phenotype	J:123951

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