Smad6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smad6
SMAD family member 6
MGI:1336883

24 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Smad6^b2b390Clo/Smad6^b2b390Clo C57BL/6J-Smad6^b2b390Clo	d-loop transposition of the great arteries	J:175213
	double outlet right ventricle	J:175213
	muscular ventricular septal defect	J:175213
	overriding aortic valve	J:175213
	perimembraneous ventricular septal defect	J:175213
	tricuspid valve atresia	J:175213
Smad6^tm1Glvn/Smad6^tm1Glvn involves: 129S6/SvEvTac * BALB/cByJ	abnormal aorta morphology	J:60214
	abnormal blood vessel physiology	J:60214
	abnormal cardiac epithelial to mesenchymal transition	J:60214
	abnormal cardiovascular system physiology	J:60214
	abnormal coronary vessel morphology	J:60214
	abnormal endocardium morphology	J:60214
	abnormal heart morphology	J:60214
	abnormal heart valve morphology	J:60214
	abnormal thrombosis	J:60214
	abnormal truncus arteriosus septation	J:60214
	decreased vasodilation	J:60214
	heart valve hyperplasia	J:60214
	increased systemic arterial blood pressure	J:60214
	mitral valve hyperplasia	J:60214
	normal mortality/aging	J:60214
	poor circulation	J:60214
	preweaning lethality, incomplete penetrance	J:60214
	pulmonary valve hyperplasia	J:60214

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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